Results 1 to 10 of about 16,770 (217)

Viability Criteria during Liver Ex-Situ Normothermic and Hypothermic Perfusion [PDF]

Medicina (Lithuania), 2022
With the increased use of extended-criteria donors, machine perfusion became a beneficial alternative to cold storage in preservation strategy for donor livers with the intent to expand donor pool. Both normothermic and hypothermic approach achieved good
Andrea Lauterio, Paolo De Simone, Davide Ghinolfi   +2 more
exaly   +4 more sources

Alternative Preservation Strategies of Donation After Circulatory Death Hearts: Effect of Cold Ischemia Time Before Normothermic Machine Perfusion [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Donation after circulatory death (DCD) offers a promising strategy to expand the donor pool by 20% to 30%. However, DCD heart grafts experience warm ischemia injury, making effective graft viability assessment before transplantation prudent ...
Manuela Lopera Higuita, Emmanuella O. Ajenu, Maya Bolger‐Chen, George Olverson, Soheila Ali Akbari Ghavimi, Si Young Lee, Taku Kasai, William Michaud, Chukwudi Chijioke, Bhuban Ruidas, Allison Pitti, Nathan Minie, Joseph Catricala, Doug Vincent, Selena Li, David D'Alessandro, Elena Aikawa, Sasha A. Singh, Marie Billaud, Asishana A. Osho, Shannon N. Tessier, S. Alireza Rabi   +21 more
doaj   +2 more sources

Editorial: Current developments in artificial organs and engineered ex-situ perfused organs [PDF]

Transplant International
Cristiano Amarelli, Jutta Arens, Cécile Legallais, Thierry Berney, Thierry Berney   +4 more
doaj   +2 more sources

Hemodynamics and Metabolic Parameters in Normothermic Kidney Preservation Are Linked With Donor Factors, Perfusate Cells, and Cytokines

Frontiers in Medicine, 2022
Kidney transplantation is the best renal-replacement option for most patients with end-stage renal disease. Normothermic machine preservation (NMP) of the kidney has been studied extensively during the last two decades and implemented in clinical trials.
Annemarie Weissenbacher, Annemarie Weissenbacher, John P. Stone, John P. Stone, Maria Letizia Lo Faro, James P. Hunter, Rutger J. Ploeg, Constantin C. Coussios, James E. Fildes, James E. Fildes, Peter J. Friend   +10 more
doaj   +1 more source

Video analysis of ex vivo beating hearts during preservation on the TransMedics® organ care system

Frontiers in Cardiovascular Medicine, 2023
BackgroundReliable biomarkers for assessing the viability of the donor hearts undergoing ex vivo perfusion remain elusive. A unique feature of normothermic ex vivo perfusion on the TransMedics® Organ Care System (OCS™) is that the donor heart is ...
Michelle Mendiola Pla, Silvia Berrettoni, Franklin H. Lee, Giacomo Rozzi, Federica Marrano, Ryan T. Gross, Amy Evans, David C. Wendell, Paul Lezberg, Margherita Burattini, Margherita Burattini, Francesco Paolo lo Muzio, Lorenzo Fassina, Carmelo A. Milano, Marie-Louise Bang, Marie-Louise Bang, Dawn E. Bowles, Michele Miragoli, Michele Miragoli   +18 more
doaj   +1 more source

Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates ex situ innate immune responses

Frontiers in Immunology, 2022
Access to liver transplantation is limited by a significant organ shortage. The recent introduction of machine perfusion technology allows surgeons to monitor and assess ex situ liver function prior to transplantation. However, many donated organs are of
Siavash Raigani, Siavash Raigani, John Santiago, Anders Ohman, Megan Heaney, Sofia Baptista, Sofia Baptista, Taylor M. Coe, Reinier J. de Vries, Ivy Rosales, Angela Shih, James F. Markmann, James F. Markmann, Philip Gruppuso, Korkut Uygun, Korkut Uygun, Jennifer Sanders, Heidi Yeh   +17 more
doaj   +1 more source

The Role of Normothermic Machine Perfusion in Extended Criteria Donor Grafts: A New Direction in Liver Graft Assessment and Preservation

Livers, 2023
Despite improvements in short-term and long-term outcomes of liver transplant patients, the discrepancy between the number of available livers and transplant candidates continues to increase.
Dima Malkawi, Kush Savsani, Anjelica Alfonso, Seung Duk Lee, Nicholas James, Devanand Sarkar, Daisuke Imai, Aamir Khan, Amit Sharma, Vinay Kumaran, David Bruno, Adrian Cotterell, Marlon F. Levy   +12 more
doaj   +1 more source

Ex situ Normothermic Split Liver Machine Perfusion: Protocol for Robust Comparative Controls in Liver Function Assessment Suitable for Evaluation of Novel Therapeutic Interventions in the Pre-clinical Setting

Frontiers in Surgery, 2021
Background:Ex situ donor liver machine perfusion is a promising tool to assess organ viability prior to transplantation and platform to investigate novel therapeutic interventions.
Joseph A. Attard, Joseph A. Attard, Joseph A. Attard, Daniel-Clement Osei-Bordom, Daniel-Clement Osei-Bordom, Yuri Boteon, Yuri Boteon, Yuri Boteon, Lorraine Wallace, Lorraine Wallace, Vincenzo Ronca, Vincenzo Ronca, Gary Reynolds, Gary Reynolds, M. T. P. R. Perera, Ye Htun Oo, Ye Htun Oo, Ye Htun Oo, Ye Htun Oo, Hynek Mergental, Hynek Mergental, Hynek Mergental, Darius F. Mirza, Simon C. Afford, Simon C. Afford   +24 more
doaj   +1 more source

Role of normothermic machine perfusion in liver transplantation: Current trends and outcomes

Surgery in Practice and Science, 2022
Background: Liver transplantation is the only known curative treatment option for end-stage liver diseases and failure; however, there is an imbalance between the number of available liver organs for transplant and the number of patients as recipients ...
Mahmoudreza Moein, Jonathan Capelin, Joseph F. Toth, Dylan Tylor, Zoe M. Weiss, Bhavani G. Murugesan, Reza F. Saidi   +6 more
doaj   +1 more source

Improved Normothermic Machine Perfusion After Short Oxygenated Hypothermic Machine Perfusion of Ischemically Injured Porcine Kidneys

Transplantation Direct, 2021
Background. In an era where global kidney shortage has pushed the field of transplantation towards using more marginal donors, modified kidney preservation techniques are currently being reviewed.
Stina Lignell, MD, Stine Lohmann, MD, Kaithlyn M. Rozenberg, BSc, Henri G. D. Leuvenink, PhD, Merel B. F. Pool, MD, Kate R. Lewis, MSc, Cyril Moers, MD, PhD, James P. Hunter, MD, Bsc(hons), Rutger J. Ploeg, MD, PhD, Marco Eijken, PhD, Ulla Møldrup, MD, Søren Krag, PhD, Carla C. Baan, PhD, Bjarne Kuno Møller, MD, PhD, Anna Krarup Keller, MD, PhD, Bente Jespersen, MD, PhD   +15 more
doaj   +1 more source