Results 1 to 10 of about 1,873,770 (160)

Subnormothermic Machine Perfusion of Steatotic Livers Results in Increased Energy Charge at the Cost of Anti-Oxidant Capacity Compared to Normothermic Perfusion [PDF]

Metabolites, 2019
There continues to be significant debate regarding the most effective mode of ex situ machine perfusion of livers for transplantation. Subnormothermic (SNMP) and normothermic machine perfusion (NMP) are two methods with different benefits.
Negin Karimian, Siavash Raigani, Viola Huang, Sonal Nagpal, Ehab O. A. Hafiz, Irene Beijert, Paria Mahboub, Robert J. Porte, Korkut Uygun, Martin Yarmush, Heidi Yeh   +10 more
doaj   +5 more sources

Metabolite-enhanced normothermic machine perfusion improves kidney transplant viability [PDF]

JCI Insight
Normothermic machine perfusion (NMP) has become a valuable tool to expand the pool of transplantable organs. However, the application of NMP to kidneys presents substantial challenges, mostly due to high variability in the composition of currently used ...
Jan Czogalla, Fabian Hausmann, Simon Lagies, Sydney E. Gies, Sabrina Christiansen, Nico Kaiser, Fabian Haas, Yusuke Okabayashi, Dominik Kylies, Smilla Hofmann, Rossana Franzin, Niklas Sabra, Sarah Bouari, Yitian Fang, Gisela Ambagtsheer, Ilka Edenhofer, Silvia Chilla, Anne K. Mühlig, Marina Zimmermann, Milagros N. Wong, Takashi Yokoo, Oliver Kretz, Maja Lindenmeyer, Florian Grahammer, Martin J. Hoogduijn, Ron de Bruin, Malte Kuehl, Sonja Hänzelmann, Bernd Kammerer, Loreto Gesualdo, Stefan Bonn, Robert C. Minnee, Tobias B. Huber, Victor G. Puelles   +33 more
doaj   +3 more sources

Improved Normothermic Machine Perfusion After Short Oxygenated Hypothermic Machine Perfusion of Ischemically Injured Porcine Kidneys [PDF]

Transplantation Direct, 2021
Background. In an era where global kidney shortage has pushed the field of transplantation towards using more marginal donors, modified kidney preservation techniques are currently being reviewed.
Stina Lignell, MD, Stine Lohmann, MD, Kaithlyn M. Rozenberg, BSc, Henri G. D. Leuvenink, PhD, Merel B. F. Pool, MD, Kate R. Lewis, MSc, Cyril Moers, MD, PhD, James P. Hunter, MD, Bsc(hons), Rutger J. Ploeg, MD, PhD, Marco Eijken, PhD, Ulla Møldrup, MD, Søren Krag, PhD, Carla C. Baan, PhD, Bjarne Kuno Møller, MD, PhD, Anna Krarup Keller, MD, PhD, Bente Jespersen, MD, PhD   +15 more
doaj   +4 more sources

Physiological Normothermic Machine Perfusion Enhances Kidney Preservation Versus the Established UK Normothermic Machine Perfusion Assessment Protocol [PDF]

Kidney360
Key Points. Physiological normothermic machine perfusion kept kidneys viable for 12 hours with better hemodynamics, urine output, and metabolic stability than clinical normothermic machine perfusion.
John P. Stone, William Norton, William R. Cowey, Emily L. Milburn, Georgina E. Chesworth, Amy F. Stewart, Corban J.T. Bowers, Emanuele Ricci, Timothy R. Entwistle, Kavit Amin, Marc Clancy, James E. Fildes   +11 more
doaj   +2 more sources

Role of normothermic machine perfusion in liver transplantation: Current trends and outcomes

Surgery in Practice and Science, 2022
Background: Liver transplantation is the only known curative treatment option for end-stage liver diseases and failure; however, there is an imbalance between the number of available liver organs for transplant and the number of patients as recipients ...
Mahmoudreza Moein, Jonathan Capelin, Joseph F. Toth, Dylan Tylor, Zoe M. Weiss, Bhavani G. Murugesan, Reza F. Saidi   +6 more
doaj   +3 more sources

Real-World Use of Normothermic Machine Perfusion in Liver Transplantation: A Multi-Institutional Experience From the National Organ Perfusion Registry. [PDF]

Clin Transplant
ABSTRACT Normothermic machine perfusion (NMP) has enabled increased utilization of high‐risk liver allografts; however, real‐world data describing use, perfusion logistics, and associated outcomes remain limited. We established the National Organ Perfusion Registry (NOPR), a multicenter collaborative registry designed to capture granular perfusion data
Cortez AR, Loh WS, Sheskey S, Braun HJ, Mehta A, Connelly C, Schenk A, Alebrahim M, Patel R, McLamb LA, Barbas A, Wisel SA, Roll GR, Sheetz KH.   +13 more
europepmc   +2 more sources

When Machine Perfusion Falls Short: Identifying Risks of Liver Graft Failure After Normothermic Machine Perfusion. [PDF]

Artif Organs
Analysis of 4928 normothermic machine perfusion liver transplants reveals that recipient factors, particularly MELD ≥ 35, surgical complexity, ICU status, and functional impairment are stronger predictors of graft failure than donor characteristics, emphasizing the continued importance of clinical judgment in patient selection.
Matevish LE, Malik AK, Harris M, Anouti A, Coe TM, Moosburner S, Raschzok N, Mufti A, Vagefi PA, Patel MS.   +9 more
europepmc   +2 more sources

Comparing Early Graft Dysfunction Scores in Liver Transplantation After Ex-Situ Normothermic Machine Perfusion. [PDF]

Clin Transplant
ABSTRACT Introduction As normothermic machine perfusion (NMP) maintains liver grafts in a near‐physiologic state, uncoupling ischemia–reperfusion injury from the recipient, the validity of early graft dysfunction scores from the static cold storage (SCS) era are uncertain.
Shah K, Castellanos S, Logan AJ, Gorelik L, Nolan A, Iyer M, Stein LV, Chen W, Obana A, Limkemann A, Singh N, Black S, Washburn WK, Schenk AD, Alebrahim M, Punjala SR.   +15 more
europepmc   +2 more sources

Alternative Preservation Strategies of Donation After Circulatory Death Hearts: Effect of Cold Ischemia Time Before Normothermic Machine Perfusion [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Donation after circulatory death (DCD) offers a promising strategy to expand the donor pool by 20% to 30%. However, DCD heart grafts experience warm ischemia injury, making effective graft viability assessment before transplantation prudent ...
Manuela Lopera Higuita, Emmanuella O. Ajenu, Maya Bolger‐Chen, George Olverson, Soheila Ali Akbari Ghavimi, Si Young Lee, Taku Kasai, William Michaud, Chukwudi Chijioke, Bhuban Ruidas, Allison Pitti, Nathan Minie, Joseph Catricala, Doug Vincent, Selena Li, David D'Alessandro, Elena Aikawa, Sasha A. Singh, Marie Billaud, Asishana A. Osho, Shannon N. Tessier, S. Alireza Rabi   +21 more
doaj   +2 more sources

Normothermic Machine Perfusion vs. Static Cold Storage for DBD Liver Transplantation in High-MELD Recipients: A Single-Center Retrospective Study. [PDF]

J Hepatobiliary Pancreat Sci
ABSTRACT Background and Purpose While normothermic machine perfusion (NMP) has benefits over static cold storage (SCS), its efficacy in high‐acuity recipients with high Model for End‐Stage Liver Disease (MELD) scores, particularly using a back‐to‐base application model, is not well established.
Sambommatsu Y, Imai D, Savsani K, Datta M, Tarashi J, Hallesy J, Wolfe S, Yokota I, Lee SD, Bruno DA.   +9 more
europepmc   +2 more sources