Results 31 to 40 of about 1,873,770 (160)

The role of sequential normothermic regional perfusion and end-ischemic normothermic machine perfusion in liver transplantation from very extended uncontrolled donation after cardiocirculatory death

, 2022
The use of pre-procurement normothermic regional perfusion (NRP) allowed us to implement controlled DCD liver transplantation with results comparable to brain death donors, but the use of uncontrolled DCD is declining due to logistic challenges and the ...
Bindi, Maria, Torri, Francesco, Del Turco, Serena, Melandro, Fabio, Esposito, Massimo, Biancofiore, Giandomenico, Lazzeri, Chiara, De Simone, Paolo, Peris, Adriano, Maria Isabella Rotondo, Ghinolfi, Davide, Basta, Giuseppina, Davide Ghinolfi, Francesco Torri, Rotondo, Maria Isabella, Chiara Lazzeri, Serena Del Turco, Paolo De Simone, Giuseppina Basta, Massimo Esposito, Fabio Melandro, Giandomenico Biancofiore, Adriano Peris, Maria Bindi   +23 more
core   +1 more source

Combined Hypothermic and Normothermic Machine Perfusion Improves Functional Recovery of Extended Criteria Donor Livers [PDF]

, 2018
Hypothermic oxygenated perfusion (HOPE) and normothermic perfusion are seen as distinct techniques of ex situ machine perfusion of the liver. We aimed to demonstrate the feasibility of combining both techniques and whether it would improve functional ...
Darius F. Mirza, Afford, Simon C, Wallace, Lorraine, Hynek Mergental, Mirza, Darius F, Andrea Schlegel, Attard, Joseph, Laing, Richard W, Joseph Attard, Richard W. Laing, M. Thamara P. R. Perera, Simon C. Afford, Bhogal, Ricky H, Desley A. H. Neil, Smith, Amanda, Yuri L. Boteon, Stefan Hübscher, Neil, Desley A H, Hübscher, Stefan, Ricky H. Bhogal, Boteon, Yuri L, Perera, M Thamara P R, Mergental, Hynek, Amanda Smith, Schlegel, Andrea, Lorraine Wallace   +25 more
core   +1 more source

Oxygen carriers affect kidney immunogenicity during ex-vivo machine perfusion

Frontiers in Transplantation, 2023
Normothermic ex-vivo machine perfusion provides a powerful tool to improve donor kidney preservation and a route for the delivery of pharmacological or gene therapeutic interventions prior to transplantation.
Tamina Rother, Carina Horgby, Katharina Schmalkuche, Jonathan M. Burgmann, Fabian Nocke, Johannes Jägers, Jessica Schmitz, Jan Hinrich Bräsen, Miriam Cantore, Franck Zal, Katja B. Ferenz, Katja B. Ferenz, Rainer Blasczyk, Constanca Figueiredo   +13 more
doaj   +1 more source

The role of oxygenation in kidney and liver machine perfusion

Трансплантология (Москва), 2023
Background. Organ transplantation is the optimal decision for patients in the end stage of many diseases. Certain conditions are required for the transportation and preservation of a donor organ after explantation, including factors such as temperature ...
M. S. Novruzbekov, A. G. Balkarov, E. Yu. Anosova, I. V. Dmitriev, Yu. A. Anisimov, N. S. Zhuravel, E. V. Klychnikova, A. S. Bogdanova, B. I. Yaremin   +8 more
doaj   +1 more source

Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation

EBioMedicine, 2020
Background: Mitochondrial succinate accumulation has been suggested as key event for ischemia reperfusion injury in mice. No specific data are however available on behavior of liver mitochondria during ex situ machine perfusion in clinical transplant ...
Andrea Schlegel, Xavier Muller, Matteo Mueller, Anna Stepanova, Philipp Kron, Olivier de Rougemont, Paolo Muiesan, Pierre-Alain Clavien, Alexander Galkin, David Meierhofer, Philipp Dutkowski   +10 more
doaj   +1 more source

Long-term ex situ normothermic perfusion of human split livers for more than 1 week

Nature Communications, 2023
Current machine perfusion technology permits livers to be preserved ex situ for short periods to assess viability prior to transplant. Long-term normothermic perfusion of livers is an emerging field with tremendous potential for the assessment, recovery,
Ngee-Soon Lau, Mark Ly, Claude Dennis, Andrew Jacques, Marti Cabanes-Creus, Shamus Toomath, Joanna Huang, Nicole Mestrovic, Paul Yousif, Sumon Chanda, Chuanmin Wang, Leszek Lisowski, Ken Liu, James G. Kench, Geoffrey McCaughan, Michael Crawford, Carlo Pulitano   +16 more
doaj   +1 more source

The Role of Normothermic Machine Perfusion in Liver Transplantation.

, 2020
To expand the donor pool of suitable organs for transplantation, there is an increased interest in utilizing extended criteria donor grafts (ECD). Ex-situ machine perfusion has shown to be a promising new modality in the organ preservation field to ...
Martins, Paulo N, Quintini, Cristiano, Buchwald, Julianna E, Mergental, Hynek, Vargas, Luciano   +4 more
core   +1 more source

Normothermic Machine Perfusion (NMP) Inhibits Proinflammatory Responses in the Liver and Promotes Regeneration

, 2019
Liver transplantation (LT) is a successful treatment for patients with liver failure. However, organ shortage results in over 11% of patients losing their chance of a transplant attributed to liver decompensation (LD) and death.
Jassem, W., Xystrakis, E., Sanchez-Fueyo, A., Lozano, J.J., Jabri, Y., Huang, X., Ma, Y., Coussios, C.C., Rela, M., Martinez-Llordella, M., Quaglia, A., Ghnewa, Y.G., Yuksel, M., Friend, P., Heaton, N., Pop, O.   +15 more
core   +1 more source

Successful transplantation of porcine liver grafts following 48-hour normothermic preservation.

PLoS ONE, 2017
Current cold storage organ preservation technique fails to preserve marginal donor grafts sufficiently. Evidence from large animal experiments suggests superiority of normothermic machine preservation of liver allografts.
Thomas Vogel, Jens G Brockmann, David Pigott, Desley A H Neil, Anand S Rathnasamy Muthusamy, Constantin C Coussios, Peter J Friend   +6 more
doaj   +1 more source

Development of a rat forelimb vascularized composite allograft (VCA) perfusion protocol.

PLoS ONE, 2023
Vascularized composite allografts (VCAs) refer to en bloc heterogenous tissue that is transplanted to restore form and function after amputation or tissue loss.
Casie A Pendexter, Omar Haque, Mohammadreza Mojoudi, Sarah Maggipinto, Marion Goutard, Simona Baicu, Alexandre G Lellouch, James F Markmann, Gerald Brandacher, Heidi Yeh, Shannon N Tessier, Curtis Cetrulo, Korkut Uygun   +12 more
doaj   +2 more sources