Results 1 to 10 of about 41,057 (216)
Machine perfusion of the liver and bioengineering
Journal of Hepatology, 2023 With the increasing number of accepted candidates on waiting lists worldwide, there is an urgent need to expand the number and the quality of donor livers. Dynamic preservation approaches have demonstrated various benefits, including improving liver function and graft survival, and reducing liver injury and post-transplant complications.
Andrea Schlegel +2 more
exaly +3 more sources
Hypothermic machine perfusion in liver transplantation [PDF]
International Journal of Surgery, 2020 Dynamic preservation strategies are a promising option to improve graft quality before transplantation, and to extend preservation time for either logistic or treatment reasons. In contrast to normothermic oxygenated perfusion, which intends to mimic physiological conditions in the human body, with subsequent clinical application for up to 24 hrs ...
Karangwa, S +5 more
+10 more sources
Research progress on hepatic machine perfusion [PDF]
International Journal of Medical Sciences, 2021 Nowadays, liver transplantation is the most effective treatment for end-stage liver disease. However, the increasing imbalance between growing demand for liver transplantation and the shortage of donor pool restricts the development of liver transplantation. How to expand the donor pool is a significant problem to be solved clinically.
Gao, Junda +3 more
openaire +2 more sources
Machine perfusion of thoracic organs [PDF]
Journal of Thoracic Disease, 2018 This article summarizes recent knowledge and clinical advances in machine perfusion (MP) of thoracic organs. MP of thoracic organs has gained much attention during the last decade. Clinical studies are investigating the role of MP to preserve, resuscitate, and assess heart and lungs prior to transplantation.
Dirk, Van Raemdonck +3 more
openaire +2 more sources
Organ Reconditioning and Machine Perfusion in Transplantation
Transplant International, 2023 Society’s self-sufficiency in terms of organ replacement is still far away from being achieved, given the large disparity between transplant demand and donor organ availability. In the attempt to reduce this discrepancy and expand the donor pool, the transplant community has progressively increased the utilisation of extended-criteria donors (ECD) such
Bellini, MI +5 more
openaire +3 more sources
The dawn of liver perfusion machines [PDF]
Current Opinion in Organ Transplantation, 2018 Despite high demand, a severe shortage of suitable allografts limits the use of liver transplantation for the treatment of end-stage liver disease. The transplant community is turning to the utilization of high-risk grafts to fill the void. This review summarizes the reemergence of ex-vivo machine perfusion for liver graft preservation, including ...
Danielle, Detelich, James F, Markmann
openaire +2 more sources
Machine Perfusion for ‘Marginal’ Liver Grafts [PDF]
American Journal of Transplantation, 2008 Due to the critical shortage of deceased donor grafts, clinicians are continually expanding the criteria for an acceptable liver donor to meet the waiting list demands. However, the reduced ischemic tolerance of those extended criteria grafts jeopardizes organ viability during cold storage.
Dutkowski, P +2 more
openaire +3 more sources
Machine Perfusion of Lungs [PDF]
Current Transplantation Reports, 2019 The purpose of this review is to summarize the fundamentals, rationale, research topics, and clinical outcomes of ex vivo lung perfusion. Since the first clinical case in 2000, the usefulness of ex vivo lung perfusion to increase the donor lung pool has been supported by much evidence.
Toshihiro Okamoto +5 more
openaire +1 more source
Cell therapy during machine perfusion [PDF]
Transplant International, 2020 There has been increasing use of organs from extended criteria or donation after circulatory death donors to meet the demands of the transplant waiting list. Over the past decade, there has been considerable progress in technologies to preserve organs prior to transplantation to improve the function of these marginal organs.
Emily R. Thompson +4 more
openaire +2 more sources
Machine perfusion strategies in liver transplantation
HepatoBiliary Surgery and Nutrition, 2019 Machine perfusion is a hot topic in liver transplantation and several new perfusion concepts are currently developed. Prior to introduction into routine clinical practice, however, such perfusion approaches need to demonstrate their impact on liver function, post-transplant complications, utilization rates of high-risk organs, and cost benefits ...
Schlegel, Andrea +2 more
openaire +5 more sources