Results 21 to 30 of about 45,056 (211)

Development of a rat forelimb vascularized composite allograft (VCA) perfusion protocol.

PLoS ONE, 2023
Vascularized composite allografts (VCAs) refer to en bloc heterogenous tissue that is transplanted to restore form and function after amputation or tissue loss.
Casie A Pendexter, Omar Haque, Mohammadreza Mojoudi, Sarah Maggipinto, Marion Goutard, Simona Baicu, Alexandre G Lellouch, James F Markmann, Gerald Brandacher, Heidi Yeh, Shannon N Tessier, Curtis Cetrulo, Korkut Uygun   +12 more
doaj   +2 more sources

Orthotopic Transplantation of the Full-length Porcine Intestine After Normothermic Machine Perfusion

Transplantation Direct, 2022
Background. Successful intestinal transplantation is currently hindered by graft injury that occurs during procurement and storage, which contributes to postoperative sepsis and allograft rejection.
Nader Abraham, MBBS, Elsa K. Ludwig, DVM, Cecilia R. Schaaf, DVM, PhD, Brittany Veerasammy, DVM, Amy S. Stewart, DVM, PhD, Caroline McKinney, DVM, MPH, John Freund, BS, John Brassil, MS, Kannan P. Samy, MD, Qimeng Gao, MD, MHS, Riley Kahan, MBS, Donna Niedzwiecki, PhD, Diana M. Cardona, MD, Katherine S. Garman, MD, Andrew S. Barbas, MD, Debra L. Sudan, MD, Liara M. Gonzalez, DVM, PhD   +16 more
doaj   +1 more source

Role of normothermic machine perfusion in liver transplantation: Current trends and outcomes

Surgery in Practice and Science, 2022
Background: Liver transplantation is the only known curative treatment option for end-stage liver diseases and failure; however, there is an imbalance between the number of available liver organs for transplant and the number of patients as recipients ...
Mahmoudreza Moein, Jonathan Capelin, Joseph F. Toth, Dylan Tylor, Zoe M. Weiss, Bhavani G. Murugesan, Reza F. Saidi   +6 more
doaj   +1 more source

Improved Normothermic Machine Perfusion After Short Oxygenated Hypothermic Machine Perfusion of Ischemically Injured Porcine Kidneys

Transplantation Direct, 2021
Background. In an era where global kidney shortage has pushed the field of transplantation towards using more marginal donors, modified kidney preservation techniques are currently being reviewed.
Stina Lignell, MD, Stine Lohmann, MD, Kaithlyn M. Rozenberg, BSc, Henri G. D. Leuvenink, PhD, Merel B. F. Pool, MD, Kate R. Lewis, MSc, Cyril Moers, MD, PhD, James P. Hunter, MD, Bsc(hons), Rutger J. Ploeg, MD, PhD, Marco Eijken, PhD, Ulla Møldrup, MD, Søren Krag, PhD, Carla C. Baan, PhD, Bjarne Kuno Møller, MD, PhD, Anna Krarup Keller, MD, PhD, Bente Jespersen, MD, PhD   +15 more
doaj   +1 more source

A fully automated normothermic machine perfusion system for kidney grafts supporting physiological motivated flow profiles

Current Directions in Biomedical Engineering, 2023
Research showed that the normothermic machine perfusion of kidneys can enable prolonged storage and improve conditions compared to traditional cold storage. For research in this area, there is a demand for a long-term in vitro perfusion setup.
Wiartalla Marc, Berg Frederik, Kühn Jahn, Buglowski Mateusz, Bleilevens Christian, Kowalewski Stefan, Stollenwerk André   +6 more
doaj   +1 more source

Viability Criteria during Liver Ex-Situ Normothermic and Hypothermic Perfusion

Medicina, 2022
With the increased use of extended-criteria donors, machine perfusion became a beneficial alternative to cold storage in preservation strategy for donor livers with the intent to expand donor pool. Both normothermic and hypothermic approach achieved good
Fabio Melandro, Riccardo De Carlis, Francesco Torri, Andrea Lauterio, Paolo De Simone, Luciano De Carlis, Davide Ghinolfi   +6 more
doaj   +1 more source

Subnormothermic Machine Perfusion of Steatotic Livers Results in Increased Energy Charge at the Cost of Anti-Oxidant Capacity Compared to Normothermic Perfusion

Metabolites, 2019
There continues to be significant debate regarding the most effective mode of ex situ machine perfusion of livers for transplantation. Subnormothermic (SNMP) and normothermic machine perfusion (NMP) are two methods with different benefits.
Negin Karimian, Siavash Raigani, Viola Huang, Sonal Nagpal, Ehab O. A. Hafiz, Irene Beijert, Paria Mahboub, Robert J. Porte, Korkut Uygun, Martin Yarmush, Heidi Yeh   +10 more
doaj   +1 more source

Advances in Hypothermic and Normothermic Perfusion in Kidney Transplantation

Transplantology, 2021
Hypothermic and normothermic machine perfusion in kidney transplantation are purported to exert a beneficial effect on post-transplant outcomes compared to the traditionally used method of static cold storage. Kidney perfusion techniques provide a window
Thomas B. Smith, Michael L. Nicholson, Sarah A. Hosgood   +2 more
doaj   +1 more source

Distinguishing between paediatric brain tumour types using multi-parametric magnetic resonance imaging and machine learning: A multi-site study

NeuroImage: Clinical, 2020
The imaging and subsequent accurate diagnosis of paediatric brain tumours presents a radiological challenge, with magnetic resonance imaging playing a key role in providing tumour specific imaging information. Diffusion weighted and perfusion imaging are
James T. Grist, Stephanie Withey, Lesley MacPherson, Adam Oates, Stephen Powell, Jan Novak, Laurence Abernethy, Barry Pizer, Richard Grundy, Simon Bailey, Dipayan Mitra, Theodoros N. Arvanitis, Dorothee P. Auer, Shivaram Avula, Andrew C Peet   +14 more
doaj   +1 more source

Machine Perfusion of Donation After Circulatory Death Liver and Lungs Before Combined Liver-lung Transplantation

Transplantation Direct, 2021
Shortage of deceased donor organs for transplantation has led to the increased use of organs from donation after circulatory death (DCD) donors. There are currently no reports describing outcomes after multiorgan transplantation with DCD livers.
Otto B. van Leeuwen, PhD, Isabel M.A. Brüggenwirth, BSc, Ruben H.J. de Kleine, MD, Aad P. van den Berg, MD, PhD, Erik A.M. Verschuuren, MD, PhD, Michiel E. Erasmus, MD, PhD, Robert J. Porte, MD, PhD   +6 more
doaj   +1 more source