Results 21 to 30 of about 42,330 (258)

The dawn of liver perfusion machines [PDF]

Current Opinion in Organ Transplantation, 2018
Despite high demand, a severe shortage of suitable allografts limits the use of liver transplantation for the treatment of end-stage liver disease. The transplant community is turning to the utilization of high-risk grafts to fill the void. This review summarizes the reemergence of ex-vivo machine perfusion for liver graft preservation, including ...
Danielle, Detelich, James F, Markmann
openaire   +2 more sources

A fully automated normothermic machine perfusion system for kidney grafts supporting physiological motivated flow profiles

Current Directions in Biomedical Engineering, 2023
Research showed that the normothermic machine perfusion of kidneys can enable prolonged storage and improve conditions compared to traditional cold storage. For research in this area, there is a demand for a long-term in vitro perfusion setup.
Wiartalla Marc, Berg Frederik, Kühn Jahn, Buglowski Mateusz, Bleilevens Christian, Kowalewski Stefan, Stollenwerk André   +6 more
doaj   +1 more source

Machine Perfusion for ‘Marginal’ Liver Grafts [PDF]

American Journal of Transplantation, 2008
Due to the critical shortage of deceased donor grafts, clinicians are continually expanding the criteria for an acceptable liver donor to meet the waiting list demands. However, the reduced ischemic tolerance of those extended criteria grafts jeopardizes organ viability during cold storage.
Dutkowski, P, de Rougemont, O, Clavien, P A   +2 more
openaire   +3 more sources

Viability Criteria during Liver Ex-Situ Normothermic and Hypothermic Perfusion

Medicina, 2022
With the increased use of extended-criteria donors, machine perfusion became a beneficial alternative to cold storage in preservation strategy for donor livers with the intent to expand donor pool. Both normothermic and hypothermic approach achieved good
Fabio Melandro, Riccardo De Carlis, Francesco Torri, Andrea Lauterio, Paolo De Simone, Luciano De Carlis, Davide Ghinolfi   +6 more
doaj   +1 more source

Machine Perfusion of Lungs [PDF]

Current Transplantation Reports, 2019
The purpose of this review is to summarize the fundamentals, rationale, research topics, and clinical outcomes of ex vivo lung perfusion. Since the first clinical case in 2000, the usefulness of ex vivo lung perfusion to increase the donor lung pool has been supported by much evidence.
Toshihiro Okamoto, Hiromichi Niikawa, Kamal Ayyat, Ichiro Sakanoue, Sayf Said, Kenneth R. McCurry   +5 more
openaire   +1 more source

Advances in Hypothermic and Normothermic Perfusion in Kidney Transplantation

Transplantology, 2021
Hypothermic and normothermic machine perfusion in kidney transplantation are purported to exert a beneficial effect on post-transplant outcomes compared to the traditionally used method of static cold storage. Kidney perfusion techniques provide a window
Thomas B. Smith, Michael L. Nicholson, Sarah A. Hosgood   +2 more
doaj   +1 more source

Distinguishing between paediatric brain tumour types using multi-parametric magnetic resonance imaging and machine learning: A multi-site study

NeuroImage: Clinical, 2020
The imaging and subsequent accurate diagnosis of paediatric brain tumours presents a radiological challenge, with magnetic resonance imaging playing a key role in providing tumour specific imaging information. Diffusion weighted and perfusion imaging are
James T. Grist, Stephanie Withey, Lesley MacPherson, Adam Oates, Stephen Powell, Jan Novak, Laurence Abernethy, Barry Pizer, Richard Grundy, Simon Bailey, Dipayan Mitra, Theodoros N. Arvanitis, Dorothee P. Auer, Shivaram Avula, Andrew C Peet   +14 more
doaj   +1 more source

Cell therapy during machine perfusion [PDF]

Transplant International, 2020
There has been increasing use of organs from extended criteria or donation after circulatory death donors to meet the demands of the transplant waiting list. Over the past decade, there has been considerable progress in technologies to preserve organs prior to transplantation to improve the function of these marginal organs.
Emily R. Thompson, Chloe Connelly, Simi Ali, Neil S. Sheerin, Colin H. Wilson   +4 more
openaire   +2 more sources

Machine Perfusion of Donation After Circulatory Death Liver and Lungs Before Combined Liver-lung Transplantation

Transplantation Direct, 2021
Shortage of deceased donor organs for transplantation has led to the increased use of organs from donation after circulatory death (DCD) donors. There are currently no reports describing outcomes after multiorgan transplantation with DCD livers.
Otto B. van Leeuwen, PhD, Isabel M.A. Brüggenwirth, BSc, Ruben H.J. de Kleine, MD, Aad P. van den Berg, MD, PhD, Erik A.M. Verschuuren, MD, PhD, Michiel E. Erasmus, MD, PhD, Robert J. Porte, MD, PhD   +6 more
doaj   +1 more source

The Risk of Microbial Transmission in Recipients of Donor Livers That Underwent Hypothermic or Normothermic Machine Perfusion

Transplantation Direct
Background. Ex situ machine perfusion is increasingly used to preserve and assess donor livers before transplantation. Compared with traditional static cold storage (SCS), machine perfusion exposes livers to an additional risk of microbial contamination.
Chikako Endo, MD, Bianca Lascaris, MD, Isabel M. A. Brüggenwirth, MD, PhD, Jan Roggeveld, MBO, Hans Blokzijl, MD, PhD, Vincent E. de Meijer, MD, PhD, M. H. Edwina Doting, MD, PhD, Robert J. Porte, MD, PhD   +7 more
doaj   +1 more source