Machine Perfusion of the Liver: A Review of Clinical Trials
Frontiers in Surgery, 2021 Although efforts have been made by transplant centers to increase the pool of available livers by extending the criteria of liver acceptance, this practice creates risks for recipients that include primary non-function of the graft, early allograft ...
Nikolaos Serifis +5 more
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The Current Role and Future Applications of Machine Perfusion in Liver Transplantation
Bioengineering, 2023 The relative paucity of donor livers suitable for transplantation has sparked innovations to preserve and recondition organs to expand the pool of transplantable organs.
Sebastian M. Staubli +2 more
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Physiological Normothermic Machine Perfusion Enhances Kidney Preservation Versus the Established UK Normothermic Machine Perfusion Assessment Protocol [PDF]
Kidney360Key Points. Physiological normothermic machine perfusion kept kidneys viable for 12 hours with better hemodynamics, urine output, and metabolic stability than clinical normothermic machine perfusion.
John P. Stone +11 more
doaj +2 more sources
Machine perfusion for liver transplantation: opportunities and challenges for the next generation of transplant surgeons [PDF]
Frontiers in TransplantationMachine perfusion is reshaping liver transplantation by turning preservation from passive storage into an active, physiologic intervention. This review synthesizes randomized and real-world evidence on hypothermic oxygenated and normothermic approaches ...
Cody L. Mullens +4 more
doaj +2 more sources
A Comprehensive Review of Ex-Vivo Machine Perfusion in Uterus Transplantation [PDF]
Transplant InternationalUterine transplantation has revolutionized previously incurable causes of infertility. While most transplants are performed with live donors, the use of deceased donors could potentially expand the donor pool and increase the number of transplants ...
Eleni M. Drivas +8 more
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The role of oxygenation in kidney and liver machine perfusion
Трансплантология (Москва), 2023 Background. Organ transplantation is the optimal decision for patients in the end stage of many diseases. Certain conditions are required for the transportation and preservation of a donor organ after explantation, including factors such as temperature ...
M. S. Novruzbekov +8 more
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Frontiers in Transplantation, 2023 IntroductionMachine perfusion is increasingly being utilized in liver transplantation in lieu of traditional cold static organ preservation. Nevertheless, better understanding of the molecular mechanisms underlying the ischemia-reperfusion injury (IRI ...
Joohyun Kim +6 more
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The ultrastructural characteristics of porcine hepatocytes donated after cardiac death and preserved with warm machine perfusion preservation. [PDF]
PLoS ONE, 2017 The effects of warm machine perfusion preservation of liver grafts donated after cardiac death on the intracellular three-dimensional ultrastructure of the organelles in hepatocytes remain unclear. Here we analyzed comparatively the ultrastructure of the
Hiroki Bochimoto +8 more
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Recent Methods of Kidney Storage and Therapeutic Possibilities of Transplant Kidney
Biomedicines, 2022 Kidney transplantation is the standard procedure for the treatment of end-stage renal disease (ESRD). During kidney storage and before implantation, the organ is exposed to damaging factors which affect the decline in condition.
Anna Radajewska +2 more
doaj +1 more source
Frontiers in Surgery, 2021 Background:Ex situ donor liver machine perfusion is a promising tool to assess organ viability prior to transplantation and platform to investigate novel therapeutic interventions.
Joseph A. Attard +24 more
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