Results 11 to 20 of about 42,330 (258)

Machine Perfusion of the Liver: A Review of Clinical Trials

Frontiers in Surgery, 2021
Although efforts have been made by transplant centers to increase the pool of available livers by extending the criteria of liver acceptance, this practice creates risks for recipients that include primary non-function of the graft, early allograft ...
Nikolaos Serifis, Rudy Matheson, Daniel Cloonan, Charles G. Rickert, James F. Markmann, Taylor M. Coe   +5 more
doaj   +3 more sources

The Current Role and Future Applications of Machine Perfusion in Liver Transplantation

Bioengineering, 2023
The relative paucity of donor livers suitable for transplantation has sparked innovations to preserve and recondition organs to expand the pool of transplantable organs.
Sebastian M. Staubli, Carlo D. L. Ceresa, Joerg M. Pollok   +2 more
doaj   +3 more sources

Physiological Normothermic Machine Perfusion Enhances Kidney Preservation Versus the Established UK Normothermic Machine Perfusion Assessment Protocol [PDF]

Kidney360
Key Points. Physiological normothermic machine perfusion kept kidneys viable for 12 hours with better hemodynamics, urine output, and metabolic stability than clinical normothermic machine perfusion.
John P. Stone, William Norton, William R. Cowey, Emily L. Milburn, Georgina E. Chesworth, Amy F. Stewart, Corban J.T. Bowers, Emanuele Ricci, Timothy R. Entwistle, Kavit Amin, Marc Clancy, James E. Fildes   +11 more
doaj   +2 more sources

Machine perfusion of the liver and bioengineering

Journal of Hepatology, 2023
With the increasing number of accepted candidates on waiting lists worldwide, there is an urgent need to expand the number and the quality of donor livers. Dynamic preservation approaches have demonstrated various benefits, including improving liver function and graft survival, and reducing liver injury and post-transplant complications.
HYNEK Mergental, Philipp Dutkowski, Constantino Fondevila   +2 more
exaly   +3 more sources

Subnormothermic Machine Perfusion of Steatotic Livers Results in Increased Energy Charge at the Cost of Anti-Oxidant Capacity Compared to Normothermic Perfusion

Metabolites, 2019
There continues to be significant debate regarding the most effective mode of ex situ machine perfusion of livers for transplantation. Subnormothermic (SNMP) and normothermic machine perfusion (NMP) are two methods with different benefits.
Negin Karimian, Siavash Raigani, Viola Huang, Sonal Nagpal, Ehab O. A. Hafiz, Irene Beijert, Paria Mahboub, Robert J. Porte, Korkut Uygun, Martin Yarmush, Heidi Yeh   +10 more
doaj   +3 more sources

Machine perfusion for liver transplantation: opportunities and challenges for the next generation of transplant surgeons [PDF]

Frontiers in Transplantation
Machine perfusion is reshaping liver transplantation by turning preservation from passive storage into an active, physiologic intervention. This review synthesizes randomized and real-world evidence on hypothermic oxygenated and normothermic approaches ...
Cody L. Mullens, Cody L. Mullens, Cody L. Mullens, Kumaran Shanmugarajah, Glenn K. Wakam   +4 more
doaj   +2 more sources

A Comprehensive Review of Ex-Vivo Machine Perfusion in Uterus Transplantation [PDF]

Transplant International
Uterine transplantation has revolutionized previously incurable causes of infertility. While most transplants are performed with live donors, the use of deceased donors could potentially expand the donor pool and increase the number of transplants ...
Eleni M. Drivas, Siavash Khaki, Amanda H. Loftin, Amanda H. Loftin, Narges Lamsehchi, Liza Johannesson, Byoung Chol Oh, Gerald Brandacher, Gerald Brandacher   +8 more
doaj   +2 more sources

The Landscape of In Situ and Ex Situ Machine Perfusion Utilization for Liver Grafts From Noncardiac Donation After Circulatory Death Donors in the Early era of Machine Perfusion in the United States [PDF]

Transplantation Direct
Background. Donation after circulatory death (DCD) is the major contributor to the growth in deceased organ donation in the United States. Normothermic regional perfusion (NRP) and ex situ machine perfusion (es-MP) have been vital for improving organ ...
Anji Wall, MD, PhD, Jinyu Du, PhD, Matthew Snoddy, MS, Johanna Bayer, MD, Sebastian Danobeitia, MD, PhD, Seung Hee Lee, MD, Eric Martinez, MD, Amar Gupta, MD, Gege Ran, MD, William F Parker, MD, MS, Sumeet Asrani, MD, MSCI, Giuliano Testa, MD, MBA   +11 more
doaj   +2 more sources

Hypothermic machine perfusion in liver transplantation [PDF]

International Journal of Surgery, 2020
Dynamic preservation strategies are a promising option to improve graft quality before transplantation, and to extend preservation time for either logistic or treatment reasons. In contrast to normothermic oxygenated perfusion, which intends to mimic physiological conditions in the human body, with subsequent clinical application for up to 24 hrs ...
Karangwa, S, Panayotova, G, Dutkowski, P, Porte, R J, Guarrera, J V, Schlegel, A   +5 more
  +10 more sources

The role of oxygenation in kidney and liver machine perfusion

Трансплантология (Москва), 2023
Background. Organ transplantation is the optimal decision for patients in the end stage of many diseases. Certain conditions are required for the transportation and preservation of a donor organ after explantation, including factors such as temperature ...
M. S. Novruzbekov, A. G. Balkarov, E. Yu. Anosova, I. V. Dmitriev, Yu. A. Anisimov, N. S. Zhuravel, E. V. Klychnikova, A. S. Bogdanova, B. I. Yaremin   +8 more
doaj   +1 more source