Results 41 to 50 of about 45,056 (211)

Advances in Kidney Transplant, Machine Perfusion, and Viability Markers

Kidney and Dialysis
Despite improvements in kidney transplantation rates, the shortage of donor kidneys remains a critical issue, exacerbated by non-utilization of recovered kidneys due to quality concerns, necessitating advancements in perfusion methods to enhance graft ...
Stephanie Y. Ohara, Mariana Chavez-Villa, Shennen Mao, Jacob Clendenon, Julie Heimbach, Randi Ryan, Lavanya Kodali, Michelle C. Nguyen, Rafael Nateras-Nunez, Caroline C. Jadlowiec   +9 more
doaj   +1 more source

Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates ex situ innate immune responses

Frontiers in Immunology, 2022
Access to liver transplantation is limited by a significant organ shortage. The recent introduction of machine perfusion technology allows surgeons to monitor and assess ex situ liver function prior to transplantation. However, many donated organs are of
Siavash Raigani, Siavash Raigani, John Santiago, Anders Ohman, Megan Heaney, Sofia Baptista, Sofia Baptista, Taylor M. Coe, Reinier J. de Vries, Ivy Rosales, Angela Shih, James F. Markmann, James F. Markmann, Philip Gruppuso, Korkut Uygun, Korkut Uygun, Jennifer Sanders, Heidi Yeh   +17 more
doaj   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Complex use of perfusion techniques in kidney transplantation from a donor with out-of-hospital cardiac arrest (clinical case)

Вестник трансплантологии и искусственных органов, 2023
Objective: to present the successful experience with a donor with out-of-hospital cardiac arrest (OHCA) in whom a set of modern perfusion techniques was used to obtain kidneys suitable for transplantation.Materials and methods.
A. V. Shabunin, M. G. Minina, P. A. Drozdov, I. A. Miloserdov, D. A. Saydulaev, V. M. Sevostyanov, E. A. Tenchurina   +6 more
doaj   +1 more source

Morphology, Transport, and Dynamics of Protein Adsorption in Open‐Cell Metal Foam

Advanced Engineering Materials, EarlyView.
Stainless steel (SS) open‐cell foams are shown to adsorb more protein per unit area than previously reported 316L SS and chromium oxide surfaces under static and flow conditions. An integrated approach combining 3D pore imaging, flow simulation, and protein adsorption experiments characterizes the foam’s performance.
Chinmaya Prerana Inguva, Joseph Lavoie, Afsaneh Rabiei   +2 more
wiley   +1 more source

A Comparative Study of Single and Dual Perfusion During End-ischemic Subnormothermic Liver Machine Preservation

Transplantation Direct, 2018
Background. It remains controversial if arterial perfusion in addition to portal vein perfusion during machine preservation improves liver graft quality. Comparative studies using both techniques are lacking. We studied the impact of using single or dual
Isabel M.A. Brüggenwirth, BSc, Carolina Moore, PhD, Paria Mahboub, Max F. Thijssen, BSc, Xiaofei E, PhD, Henri G.D. Leuvenink, PhD, Pranoti Mandrekar, PhD, Xiaofei Wang, MD, Timothy F. Kowalik, PhD, Robert J. Porte, MD, PhD, Paulo N. Martins, MD, PhD   +10 more
doaj   +1 more source

Dynamic Loading Regulates Meniscus‐Like Matrix Production in Human Mesenchymal Stromal Cell‐Seeded PET Scaffolds

Advanced Healthcare Materials, EarlyView.
Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira, Luisa de Roy, Anna‐Lotta Feldmeier, Mubashir Ahmad, Sofia Pilão, Maria Ahrens, Anita Ignatius, Carsten Linti, Andreas Martin Seitz   +8 more
wiley   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Use of Machine Perfusion to Increase the Number of Expanded Criteria Deceased Donor Kidney Transplants: A Pharmacoeconomic Analysis

Transplantation Direct
Background. The discard of expanded criteria donor (ECD) kidneys is unacceptably high, considering the growing demand for transplantation. Using machine perfusion may reduce the discard rate, increase the number of transplants, and reduce mortality on ...
Helio Tedesco Silva, Jr, MD, PhD, Teresa Raquel de Moraes Ramos, PhD, Deise De Boni Monteiro de Carvalho, MD, Gustavo Fernandes Ferreira, MD, PhD, João Marcelo Medeiros de Andrade, MD, PhD, Luis Gustavo Modelli de Andrade, MD, PhD, Mario Abbud-Filho, MD, PhD, Renato Demarchi Foresto, MD, MSc, Roberto Ceratti Manfro, MD, PhD, Ronaldo de Matos Esmeraldo, MD, MSc, Tainá Veras de Sandes Freitas, MD, PhD, Valter Duro Garcia, MD, PhD, José Medina Pestana, MD, PhD, Marcelo Cunio Machado Fonseca, MD, PhD   +13 more
doaj   +1 more source

Development of a Porcine Slaughterhouse Kidney Perfusion Model

Transplantology, 2021
Machine perfusion techniques are becoming standard care in the clinical donation and transplantation setting. However, more research is needed to understand the mechanisms of the protective effects of machine perfusion.
Leonie H. Venema, Henri G. D. Leuvenink
doaj   +1 more source