Results 31 to 40 of about 45,056 (211)

The Risk of Microbial Transmission in Recipients of Donor Livers That Underwent Hypothermic or Normothermic Machine Perfusion

Transplantation Direct
Background. Ex situ machine perfusion is increasingly used to preserve and assess donor livers before transplantation. Compared with traditional static cold storage (SCS), machine perfusion exposes livers to an additional risk of microbial contamination.
Chikako Endo, MD, Bianca Lascaris, MD, Isabel M. A. Brüggenwirth, MD, PhD, Jan Roggeveld, MBO, Hans Blokzijl, MD, PhD, Vincent E. de Meijer, MD, PhD, M. H. Edwina Doting, MD, PhD, Robert J. Porte, MD, PhD   +7 more
doaj   +1 more source

Towards Optimizing Sub-Normothermic Machine Perfusion in Fasciocutaneous Flaps: A Large Animal Study

Bioengineering, 2023
Machine perfusion has developed rapidly since its first use in solid organ transplantation. Likewise, reconstructive surgery has kept pace, and ex vivo perfusion appears as a new trend in vascularized composite allotransplants preservation. In autologous
Yanis Berkane, Alexandre G. Lellouch, Guillaume Goudot, Austin Shamlou, Irina Filz von Reiterdank, Marion Goutard, Pierre Tawa, Paul Girard, Nicolas Bertheuil, Basak E. Uygun, Mark A. Randolph, Jérôme Duisit, Curtis L. Cetrulo, Korkut Uygun   +13 more
doaj   +1 more source

A Systematic Review and Meta-Analysis of Machine Perfusion vs. Static Cold Storage of Liver Allografts on Liver Transplantation Outcomes: The Future Direction of Graft Preservation

Frontiers in Medicine, 2020
Background: Machine perfusion (MP) and static cold storage (CS) are two prevalent methods for liver allograft preservation. However, the preferred method remains controversial.Aim: To conduct a meta-analysis on the impact of MP preservation on liver ...
Junjun Jia, Junjun Jia, Yu Nie, Yu Nie, Jianhui Li, Jianhui Li, Haiyang Xie, Haiyang Xie, Lin Zhou, Lin Zhou, Jun Yu, Jun Yu, Shu-Sen Zheng, Shu-Sen Zheng   +13 more
doaj   +1 more source

Subnormothermic Ex Vivo Porcine Kidney Perfusion Improves Energy Metabolism: Analysis Using 31P Magnetic Resonance Spectroscopic Imaging

Transplantation Direct, 2022
Background. The ideal preservation temperature for donation after circulatory death kidney grafts is unknown. We investigated whether subnormothermic (22 °C) ex vivo kidney machine perfusion could improve kidney metabolism and reduce ischemia-reperfusion
Thomas Agius, MS, Julien Songeon, MS, Antoine Klauser, PhD, Florent Allagnat, PhD, Grégoire Longchamp, MD, Raphael Ruttimann, BS, Arnaud Lyon, MD, Julijana Ivaniesevic, PhD, Raphael Meier, MD, PhD, Sébastien Déglise, MD, James F. Markmann, MD, PhD, Korkut Uygun, PhD, Leo Buhler, MD, Christian Toso, MD, PhD, Jean-Marc Corpataux, MD, Francois Lazeyras, PhD, Alban Longchamp, MD, PhD   +16 more
doaj   +1 more source

Experimental Evaluation of a New Perfusion Machine Using Normothermic Cycles on Explanted Livers

IEEE Open Journal of Engineering in Medicine and Biology
Goal: Organ perfusion is a vast subject with several techniques, the most common being Hypothermic Machine Perfusion (HMP) and Normothermic Machine Perfusion (NMP).
Eleonora Barcali, Lorenzo Maggi, Rebecca Panconesi, Fabio Staderini, Leonardo Bocchi, Cosimo Nardi, Nadia Navari, Adriano Peris, Matteo Risaliti, Mauricio F. Carvalho, Fabio Marra, Philipp Dutkowski, Gian Luca Grazi, Andrea Schlegel, Filippo Bigi, Mattia Dimitri, Andrea Corvi   +16 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Cerebral Pulsed Arterial Spin Labeling Perfusion Weighted Imaging Predicts Language and Motor Outcomes in Neonatal Hypoxic-Ischemic Encephalopathy

Frontiers in Pediatrics, 2020
Rationale and Objectives: To compare cerebral pulsed arterial spin labeling (PASL) perfusion among controls, hypoxic ischemic encephalopathy (HIE) neonates with normal conventional MRI(HIE/MRI⊕), and HIE neonates with abnormal conventional MRI(HIE/MRI⊖).
Qiang Zheng, Juan Sebastian Martin-Saavedra, Sandra Saade-Lemus, Arastoo Vossough, Arastoo Vossough, Giulio Zuccoli, Fabrício Guimarães Gonçalves, Colbey W. Freeman, Minhui Ouyang, Varun Singh, Michael A. Padula, Michael A. Padula, Sara B. Demauro, Sara B. Demauro, John Flibotte, John Flibotte, Eric C. Eichenwald, Eric C. Eichenwald, John A. Detre, Raymond Wang Sze, Raymond Wang Sze, Hao Huang, Hao Huang, Misun Hwang, Misun Hwang   +24 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

24-hour Perfusion of Porcine Myocutaneous Flaps Mitigates Reperfusion Injury: A 7-day Follow-up Study

Plastic and Reconstructive Surgery, Global Open, 2022
Background:. Static cold storage is the gold standard of preservation in vascularized composite allotransplantation and allows a preservation time of 4–6 hours. Machine preservation is a promising technique for prolonged preservation; however, studies on
Kaj Brouwers, MD, Max F. Thijssen, MD, Anne Sophie Kruit, PhD, Dominique van Midden, MD, Erik J. Koers, BsC, Her J.H. Zegers, Ing., Stefan Hummelink, PhD, Dietmar J.O. Ulrich, MD, PhD   +7 more
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source