Results 41 to 50 of about 1,873,770 (160)

Sequential use of normothermic regional and ex-situ machine perfusion in DCD liver transplant [PDF]

, 2020
In Italy, 20 minutes of continuous, flat-line electrocardiogram are required for declaration of death. In the setting of organ donation after cardiocirculatory death (DCD), prolonged warm ischemia time prompted introduction of abdominal normothermic ...
Zanella, Alberto, Biancofiore, Giandomenico, De Simone, Paolo, Alberto Zanella, Peris, Adriano, Rossi, Giorgio, Ghinolfi, Davide, Marco Maggioni, Caterina Lonati, Paolo De Simone, Daniele Pezzati, Alessia Kersik, Maggioni, Marco, Erion Rreka, Kersik, Alessia, Daniele Dondossola, Lonati, Caterina, Lazzeri, Chiara, Reggiani, Paolo, Giorgio Rossi, Davide Ghinolfi, Riccardo Morganti, Cacciatoinsilla, Andrea, Chiara Lazzeri, Morganti, Riccardo, Paolo Reggiani, Giandomenico Biancofiore, Adriano Peris, Dondossola, Daniele, Andrea Cacciatoinsilla, Pezzati, Daniele, Rreka, Erion   +31 more
core   +1 more source

Machine Perfusion of the Liver: A Review of Clinical Trials

Frontiers in Surgery, 2021
Although efforts have been made by transplant centers to increase the pool of available livers by extending the criteria of liver acceptance, this practice creates risks for recipients that include primary non-function of the graft, early allograft ...
Nikolaos Serifis, Rudy Matheson, Daniel Cloonan, Charles G. Rickert, James F. Markmann, Taylor M. Coe   +5 more
doaj   +1 more source

The Dead Donor Rule and Normothermic Regional Perfusion

Hastings Center Report, EarlyView.
Abstract Normothermic regional perfusion (NRP) can be used after the circulatory determination of death to prevent or minimize organ damage before the donor's organs are retrieved. It involves restarting circulation within the donor's body to reperfuse abdominal and thoracic organs while occluding the arteries that supply oxygenated blood to the brain ...
Andrew McGee, Brendan Parent, Dale Gardiner, Drew Carter   +3 more
wiley   +1 more source

Machine perfusion in liver transplantation: a network meta-analysis

, 2021
Copyright \ua9 2021 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:.
Tingle SJ, Pandanaboyana S, Wilson CH, Figueiredo RS, Thompson ER, Mahendran B   +5 more
core   +4 more sources

Interleukin‐37 Enhances Liver NK Cell Cytotoxicity and Improves Recurrence‐Free Survival in Hepatocellular Carcinoma Patients

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Introduction Hepatocellular carcinoma (HCC) remains a major cause of cancer‐related mortality worldwide, and postoperative recurrence continues to limit long‐term survival. Liver‐resident natural killer (NK) cells are key effectors of antitumor immunity in the hepatic microenvironment. Interleukin‐37 (IL‐37), an anti‐inflammatory cytokine, has
Yuki Imaoka, Masahiro Ohira, Yuka Tanaka, Toshihiro Nakayama, Miho Akabane, Shinichiro Yokota, Sheri M. Krams, Olivia M. Martinez, Carlos O. Esquivel, Kazunari Sasaki, Hideki Ohdan   +10 more
wiley   +1 more source

The Hitchhiker's guide to isolated organ perfusion: a journey to 2040

Frontiers in Transplantation
Building on the established success of hypothermic machine perfusion (HMP) and emerging normothermic platforms, machine perfusion is poised to guide a journey toward 2040, transforming organ transplantation into an era of integrated preservation ...
John Fallon, Alex Sagar, Mohamed Elzawahry, Hatem Sadik, Kazuyuki Gyoten, Syed Hussain Abbas, Richard Dumbill, Peter Friend   +7 more
doaj   +1 more source

Ex Situ Normothermic Machine Perfusion of Donor Livers

, 2015
In contrast to conventional static cold preservation (0-4 degrees C), ex situ machine perfusion may provide better preservation of donor livers. Continuous perfusion of organs provides the opportunity to improve organ quality and allows ex situ viability
Markmann, James F., Burlage, Laura C., Uygun, Korkut, Lisman, Ton; id_orcid, Leuvenink, Henri G. D.; id_orcid, Westerkamp, Andrie C., Lisman, Ton, Leuvenink, Henri G. D., Karimian, Negin, Matton, Alix P. M., Matton, Alix P.M., Op den Dries, Sanna, Porte, Robert J., Leuvenink, Henri G.D.   +13 more
core   +1 more source

Dual acellular subnormothermic machine perfusion for enhanced uterus preservation in a swine model

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
In a porcine uterus transplantation model, subnormothermic machine perfusion reduced graft edema and better‐preserved post‐reperfusion contractility than static cold storage, highlighting its potential for uterus preservation, assessment, and future graft‐conditioning applications.
Lucile Cabanel, Haïzam Oubari, Bradley W. Ellis, Ludivine Dion, Vincent Lavoué, Carla Sousa, Loïc Van Dieren, Olivier Morel, Mark A. Randolph, Curtis L. Cetrulo Jr., Korkut Uygun, Alexandre G. Lellouch, Yanis Berkane, Basak E. Uygun   +13 more
wiley   +1 more source

Texture Analysis Using Indocyanine Green Fluorescence Measurement During Porcine Hypothermic Oxygenated Machine Perfusion

Artificial Organs, EarlyView.
A novel quantitative method using Indocyanine Green (ICG) fluorescence image for assessing organ viability during hypothermic oxygenated machine perfusion (HOPE), specifically focusing on homogeneous flow distribution analyzed with the gray‐scale level co‐occurrence matrix (GLCM) method, can predict portal vein resistance induced by ischemic ...
Yuga Okazawa, Hiromichi Obara, Taiki Mori, Satoshi Muto, Mio Takashima, Masafumi Furukawa, Hiroki Kaneko, Tetsuya Nakajo, Shohei Ishizawa, Seisuke Sakamoto, Naoto Matsuno   +10 more
wiley   +1 more source

Monitoring Mitochondrial Function With High‐Resolution Respirometry During Ex‐Situ Heart Perfusion

Artificial Organs, EarlyView.
Normothermic ESHP preserves mitochondrial respiratory function over 6 h in a porcine model (n = 6): OXPHOS capacities across NADH‐, fatty‐acid‐, and succinate‐linked pathways remain stable, with reduced cytochrome‐c control efficiency indicating improved outer‐membrane integrity. HRR provides a rapid, actionable readout for organ assessment.
Lukas Stastny, Julia Hofmann, Andras T. Meszaros, Alexandra Ampferer, Gabriel Putzer, Nina Perkins, Natalie Huemer, Florian Sommerauer, Judith Martini, Julian Wagner, Michael Grimm, Stefan Schneeberger, Julia Dumfarth   +12 more
wiley   +1 more source