Results 1 to 10 of about 193,493 (202)

Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation [PDF]

EBioMedicine, 2020
Background: Mitochondrial succinate accumulation has been suggested as key event for ischemia reperfusion injury in mice. No specific data are however available on behavior of liver mitochondria during ex situ machine perfusion in clinical transplant ...
Anna Stepanova, Olivier de Rougemont, Alexander Galkin   +2 more
exaly   +11 more sources

Hypothermic Oxygenated Machine Perfusion of the Human Donor Pancreas [PDF]

Transplantation Direct, 2018
Background. Transplantation of beta cells by pancreas or islet transplantation is the treatment of choice for a selected group of patients suffering from type 1 diabetes mellitus.
Marjolein Leemkuil, MD, Grietje Lier, MD, Marten A. Engelse, PhD, Rutger J. Ploeg, PhD, Eelco J. P. de Koning, PhD, Nils A. ‘t Hart, PhD, Christina Krikke, MD, Henri G. D. Leuvenink, PhD   +7 more
doaj   +9 more sources

Mitochondrial Reprogramming—What Is the Benefit of Hypothermic Oxygenated Perfusion in Liver Transplantation? [PDF]

Transplantology, 2021
Although machine perfusion is a hot topic today, we are just at the beginning of understanding the underlying mechanisms of protection. Recently, the first randomized controlled trial reported a significant reduction of ischemic cholangiopathies after ...
Matteo Mueller, Philipp Dutkowski, Paolo Muiesan   +2 more
exaly   +4 more sources

Suitability of a Fluorescence Method for Flavin Mononucleotide Determination in Modified HTK-Based Perfusion Solutions During Hypothermic Oxygenated Perfusion of Liver Grafts [PDF]

Methods and Protocols
A comprehensive assessment of allograft quality is essential for predicting successful transplantation and graft survival. Elevated levels of flavin mononucleotide (FMN) in perfusate obtained during hypothermic oxygenated perfusion (HOPE) may serve as a ...
Yulia B. Basok, Eugenia G. Kuznetsova, Aleksandra D. Belova, Dmitriy A. Morozov, Mikhail A. Boldyrev, Artem R. Monakhov, Nikita V. Grudinin, Vladimir K. Bogdanov, Denis M. Bondarenko, Stepan I. Zubenko, Nidzhat M. Yusuf, Sergey V. Gautier   +11 more
doaj   +2 more sources

Trophism and Homeostasis of Liver Sinusoidal Endothelial Graft Cells during Preservation, with and without Hypothermic Oxygenated Perfusion [PDF]

Biology, 2022
The aim of the present study was to evaluate the homeostasis and trophism of liver sinusoidal endothelial cells (LSECs) in vivo in different stages of liver graft donation, in order to understand the effects of graft ischemia and perfusion on LSEC ...
Francesco Vasuri, Giuliana Germinario, Carmen Ciavarella, Michele Carroli, Ilenia Motta, Sabrina Valente, Matteo Cescon, Antonia D’Errico, Gianandrea Pasquinelli, Matteo Ravaioli   +9 more
doaj   +2 more sources

Molecular and cellular adaptations to extended hypothermic oxygenated perfusion in donation-after-circulatory-death hearts in a porcine model [PDF]

Frontiers in Cardiovascular Medicine
IntroductionDonation after circulatory death (DCD) criteria serves as a potential strategy to expand the organ pool for heart transplantation. However, DCD procurement introduces prolonged warm ischemic times that accelerate endothelial and cardiomyocyte
Morgan K. Moroi, Yaagnik Kosuri, Cary Karcher, Diana Albino, Diana Albino, Anthony Campbell, Arianna Adamo, Arianna Adamo, Emre Bektik, Christine Chan, Kenmond Fung, Miroslav Sekulic, Shaheer K. Faruqi, Shaheer K. Faruqi, Craig J. Goergen, Craig J. Goergen, Melissa Tamimi, Koji Takeda, Giovanni Ferrari   +18 more
doaj   +2 more sources

Hypothermic Oxygenated Liver Perfusion: Basic Mechanisms and Clinical Application [PDF]

Current Transplantation Reports, 2015
Abstract Dynamic preservation strategies such as hypothermic machine perfusion are increasingly discussed to improve liver graft quality before transplantation. This review summarizes current knowledge of this perfusion technique for liver preservation.
Philipp Kron, Andrea Schlegel, P Dutkowski   +2 more
exaly   +4 more sources

Surgical technique of donation after circulatory death heart procurement using direct procurement and hypothermic oxygenated perfusion preservation [PDF]

JHLT Open
Introduction: Donation after circulatory death (DCD) has re-emerged as a means of expanding the donor heart pool. Current clinical practice relies mainly on direct procurement followed by normothermic machine perfusion or on thoraco-abdominal ...
K. Vandendriessche, J. Brouckaert, K. Van de Voorde, F. Gaublomme, K. Degezelle, J. Van Cleemput, A. Wallinder, F. Rega   +7 more
doaj   +2 more sources

End-ischemic hypothermic oxygenated perfusion for extended criteria donors in liver transplantation: a multicenter, randomized controlled trial—HOPExt [PDF]

Trials, 2023
Background Given the scarce donor supply, an increasing number of so-called marginal or extended criteria donor (ECD) organs are used for liver transplantation.
Pierre Pradat, Solene Pantel, Marianne Maynard, Laure Lalande, Sylvie Thevenon, Rene Adam, Marc-Antoine Allard, Fabien Robin, Michel Rayar, Emmanuel Boleslawski, Olivier Scatton, Mircea Chirica, François Faitot, Philippe Bachellier, Olivier Soubrane, Kayvan Mohkam, Jean-Yves Mabrut, Mickaël Lesurtel   +17 more
doaj   +2 more sources

Normothermic and hypothermic oxygenated perfusion for donation after circulatory death in kidney transplantation: do we pay higher risk of severe infection after transplantation?: a case report [PDF]

BMC Infectious Diseases, 2020
Background Normothermic and hypothermic oxygenated perfusion for donation after circulatory death in kidney transplantation are becoming popular in Italy, with the purpose of reducing the risk of primary non function and delayed graft function due to the
Matteo Ravaioli, Valeria Corradetti, Matteo Renzulli, Giuliana Germinario, Lorenzo Maroni, Federica Odaldi, Guido Fallani, Anna Paola Pezzuto, Daniele Parlanti, Raffaele Bova, Claudia Bini, Gaetano La Manna, Giorgia Comai   +12 more
doaj   +2 more sources