Results 11 to 20 of about 193,493 (202)

Hypothermic Oxygenated Perfusion Improves Vascular and Contractile Function by Preserving Endothelial Nitric Oxide Production in Cardiac Grafts Obtained With Donation After Circulatory Death [PDF]

Journal of the American Heart Association
BACKGROUND Cardiac donation after circulatory death is a promising option to increase graft availability. Graft preservation with 30 minutes of hypothermic oxygenated perfusion (HOPE) before normothermic machine perfusion may improve cardiac recovery ...
Sarah Longnus, Matthias Siepe, Manuel Egle   +2 more
exaly   +5 more sources

HOPE (hypothermic oxygenated perfusion) strategies in the era of dynamic liver graft preservation [PDF]

EBioMedicine, 2020
Machine devices have been around since the early days of organ preservation. Recently, James Southard [1] explained the efforts and troubles that Folkert Belzer had in shipping a kidney recovered in San Francisco (USA), to Leiden (NL), which was thus ...
Arnau Panisello-Rosello, Joan Roselló-Catafau   +1 more
doaj   +3 more sources

Impact of Hypothermic Perfusion on Immune Responses and Sterile Inflammation in a Preclinical Model of Pancreatic Transplantation

Transplantation Direct
Background. In organ transplantation, cold ischemia is associated with sterile inflammation that subsequently conditions adaptive immunity directed against the grafts during revascularization. This inflammation is responsible for venous thrombosis, which
Benoit Mesnard, MD, Sarah Bruneau, PhD, Stéphanie Le Bas-Bernardet, PhD, Etohan Ogbemudia, MD, Delphine Kervella, MD, PhD, Christophe Masset, MD, Mélanie Neel, PhD, M. David Minault, M. Jeremy Hervouet, Diego Cantarovich, MD, PhD, Jérôme Rigaud, MD, PhD, Lionel Badet, MD, PhD, Peter Friend, MD, PhD, Rutger Ploeg, MD, PhD, Gilles Blancho, MD, PhD, James Hunter, MD, PhD, Thomas Prudhomme, MD, Julien Branchereau, MD, PhD   +17 more
doaj   +3 more sources

Rescue of the Cold Preserved Rat Liver by Hypothermic Oxygenated Machine Perfusion [PDF]

American Journal of Transplantation, 2006
The aim of the study was to investigate whether hypothermic oxygenated liver perfusion after cold liver preservation resuscitated metabolic parameters and whether this treatment had a benefit for liver viability upon reperfusion. We preserved rat livers either by cold storage (UW) for 10 h, or by perfusion for 3 h (oxygenated modified UW) after 10 h ...
Dutkowski P, Graf R, Clavien PA
openaire   +4 more sources

Early experiments with hypothermic oxygenated machine perfusion of kidney grafts from extended criteria donors [PDF]

Вестник трансплантологии и искусственных органов, 2022
Objective: to evaluate the safety and efficacy of hypothermic oxygenated machine perfusion (HOPE) for kidney grafts obtained from expanded criteria donors (ECD).Materials and methods.
A. V. Shabunin, M. G. Minina, P. V. Drozdov, I. V. Nesterenko, D. A. Makeev, O. S. Zhuravel, L. R. Karapetyan, S. A. Astapovich   +7 more
doaj   +2 more sources

Texture Analysis Using Indocyanine Green Fluorescence Measurement During Porcine Hypothermic Oxygenated Machine Perfusion

Artificial Organs, EarlyView.
A novel quantitative method using Indocyanine Green (ICG) fluorescence image for assessing organ viability during hypothermic oxygenated machine perfusion (HOPE), specifically focusing on homogeneous flow distribution analyzed with the gray‐scale level co‐occurrence matrix (GLCM) method, can predict portal vein resistance induced by ischemic ...
Yuga Okazawa, Hiromichi Obara, Taiki Mori, Satoshi Muto, Mio Takashima, Masafumi Furukawa, Hiroki Kaneko, Tetsuya Nakajo, Shohei Ishizawa, Seisuke Sakamoto, Naoto Matsuno   +10 more
wiley   +2 more sources

Improved Normothermic Machine Perfusion After Short Oxygenated Hypothermic Machine Perfusion of Ischemically Injured Porcine Kidneys [PDF]

Transplantation Direct, 2021
Background. In an era where global kidney shortage has pushed the field of transplantation towards using more marginal donors, modified kidney preservation techniques are currently being reviewed.
Stina Lignell, MD, Stine Lohmann, MD, Kaithlyn M. Rozenberg, BSc, Henri G. D. Leuvenink, PhD, Merel B. F. Pool, MD, Kate R. Lewis, MSc, Cyril Moers, MD, PhD, James P. Hunter, MD, Bsc(hons), Rutger J. Ploeg, MD, PhD, Marco Eijken, PhD, Ulla Møldrup, MD, Søren Krag, PhD, Carla C. Baan, PhD, Bjarne Kuno Møller, MD, PhD, Anna Krarup Keller, MD, PhD, Bente Jespersen, MD, PhD   +15 more
doaj   +4 more sources

Hypothermic oxygenated perfusion inhibits HECTD3-mediated TRAF3 polyubiquitination to alleviate DCD liver ischemia-reperfusion injury [PDF]

Cell Death and Disease, 2021
Ischemia-reperfusion injury (IRI) is an inevitable and serious clinical problem in donations after heart death (DCD) liver transplantation. Excessive sterile inflammation plays a fateful role in liver IRI.
Wei Zhou, Zibiao Zhong, Danni Lin, Zhongzhong Liu, Qiuyan Zhang, Haoyang Xia, Sheng Peng, Anxiong Liu, Zhongshan Lu, Yanfeng Wang, Shaojun Ye, Qifa Ye   +11 more
doaj   +2 more sources

Extended hypothermic oxygenated machine perfusion enables ex situ preservation of porcine livers for up to 24 hours

JHEP Reports, 2020
Background & Aims: End-ischemic hypothermic oxygenated machine perfusion (HOPE) of the donor liver for 1–2 h mitigates ischemia-reperfusion injury during subsequent liver transplantation.
Silke B Bodewes, Ton Lisman
exaly   +3 more sources

Portal-Venous Hypothermic Oxygenated Perfusion for Liver Transplant: A Randomized Clinical Trial.

JAMA Surg
Importance Ischemia-reperfusion injury contributes to graft dysfunction after liver transplant. Hypothermic oxygenated perfusion (HOPE) has been shown to improve liver function, but its benefit in extended criteria donors in a US population remains unclear.
Reich DJ, Mao S, Satish S, Nassar A, Rizzari M, Al-Adra DP, DiNorcia J, Woloszyn J, Doyle MBM, Bohorquez H, Mihaylov P, Saharia A, Merani S, Wehrle CJ, Miller C, Axelrod D, Langnas A, Melcher ML, Akoad M, Ghobrial M, Kubal C, Roll G, Cohen A, Chapman WC, Pinna A, de Vera M, Florman S, Foley DP, Abouljoud M, Quintini C, Hashimoto K, Croome K, Taner CB, Schlegel A.   +33 more
europepmc   +2 more sources