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Trends in organ preservation [PDF]

Transplant International, 2003
Organ preservation aims to provide a viable graft with primary function post-transplant. The current basis of preservation for transplantation is static cold storage using specific preservation solutions which minimise cellular swelling and membrane pump activity, thus maintaining cellular ATP levels. The current organ shortage and consequent expansion
McLaren, A, Friend, P
openaire   +4 more sources

Perspectives in Organ Preservation [PDF]

Transplantation, 2007
Maintaining organ viability after donation until transplantation is critically important for optimal graft function and survival. To date, static cold storage is the most widely used form of preservation in every day clinical practice. Although simple and effective, it is questionable whether this method is able to prevent deterioration of organ ...
Maathuis, M, Leuvenink, H, Ploeg, R
openaire   +4 more sources

Organ reperfusion and preservation [PDF]

Frontiers in Bioscience, 2008
Organ transplantation is one of the medical success stories of the 20th century. Transplantation is, however, a victim of its own success with demand for organs far exceeding supply. The ischemia/reperfusion injury associated with organ transplantation is complex with interlinking cellular pathways and cascades.
Jamieson, R, Friend, P
openaire   +4 more sources

Isochoric Supercooling Organ Preservation System [PDF]

Bioengineering, 2023
This technical paper introduces a novel organ preservation system based on isochoric (constant volume) supercooling. The system is designed to enhance the stability of the metastable supercooling state, offering potential long-term preservation of large ...
Gabriel Năstase, Florin Botea, George-Andrei Beșchea, Ștefan-Ioan Câmpean, Alexandru Barcu, Ion Neacșu, Vlad Herlea, Irinel Popescu, Tammy T. Chang, Boris Rubinsky, Alexandru Șerban   +10 more
doaj   +3 more sources

Late toxicity after peposertib-enhanced chemoradiation in rectal cancer patients managed with organ preservation [PDF]

Clinical and Translational Radiation Oncology
Background and purpose: Combining peposertib, a DNA-PK inhibitor, with capecitabine-based chemoradiation may improve tumor response and organ preservation in rectal cancer.
W. Zambare, R. Ravella, C. Li, C.H. Crane, J.J. Cuaron, I.H. Wei, A. Wu, D. Rao, G.M. Nash, E. Pappou, V.M. Williams, M. Reyngold, P.B. Paty, M. Zinovoy, D. Roth O’Brien, L.B. Saltz, A. Cercek, M.R. Weiser, J. Garcia-Aguilar, R. Yaeger, J.J. Smith, P.B. Romesser   +21 more
doaj   +2 more sources

Organ preservation: current limitations and optimization approaches [PDF]

Frontiers in Medicine
Despite the annual rise in patients with end-stage diseases necessitating organ transplantation, the scarcity of high-quality grafts constrains the further development of transplantation.
Qiulin Ran, Jiayi Zhang, Jisheng Zhong, Ji Lin, Shuai Zhang, Guang Li, Bin You   +6 more
doaj   +2 more sources

Experimental organ preservation [PDF]

Journal of British Surgery, 1972
Abstract An experimental model for the study of organ preservation based on the isolated, biologically perfused rat heart is described. Using this model a standard storage solution has been evolved for use with initial perfusion and hypothermic storage. This solution contains Dextran 40 and insulin.
K C, Calman, P R, Bell
openaire   +4 more sources

Current practice and novel approaches in organ preservation

Frontiers in Transplantation, 2023
Organ transplantation remains the only treatment option for patients with end-stage organ failure. The last decade has seen a flurry of activity in improving organ preservation technologies, which promise to increase utilization in a dramatic fashion ...
Ozge Sila Ozgur, Ozge Sila Ozgur, Bat-Erdene Namsrai, Timothy L. Pruett, John C. Bischof, Mehmet Toner, Mehmet Toner, Erik B. Finger, Korkut Uygun, Korkut Uygun   +9 more
doaj   +3 more sources

Organ preservation: which temperature for which organ? [PDF]

Journal of International Medical Research, 2019
In 1954, Joseph Murray performed the first successful human organ transplant from a live kidney donor, Richard Herrick, into the donor’s twin, Robert. Since no form of organ preservation was available, the surgeries happen in two simultaneous operating ...
Maria Irene Bellini, Vito D’Andrea
doaj   +2 more sources

Editorial: Organ preservation for rectal cancer patients [PDF]

Frontiers in Surgery
Ionut Negoi, John R. T. Monson, Leonardo Bustamante-Lopez, Leonardo Bustamante-Lopez, Zoe Garoufalia, Vito D'Andrea, Sameh Hany Emile   +6 more
doaj   +2 more sources