Results 61 to 70 of about 1,873,770 (160)

The case for normothermic machine perfusion in liver transplantation [PDF]

, 2018
In recent years there has been growing interest in normothermic machine perfusion as a preservation method in liver transplantation. In most countries, due to a donor organ shortage, an unacceptable number of patients die whilst awaiting transplantation.
Coussios, Constantin, Nasralla, D, Ceresa, CD, Friend, PJ, Nasralla, David, David Nasralla, Peter J. Friend, Coussios, C-C, Constantin C. Coussios, Ceresa, Carlo, Friend, Peter, Carlo D. L. Ceresa   +11 more
core   +1 more source

The impact of short-term machine perfusion on the risk of cancer recurrence after rat liver transplantation with donors after circulatory death.

PLoS ONE, 2019
Hypothermic and normothermic ex vivo liver perfusions promote organ recovery after donation after circulatory death (DCD). We tested whether these perfusions can reduce the risk of hepatocellular carcinoma (HCC) recurrence in a 1h-DCD syngeneic ...
Graziano Oldani, Andrea Peloso, Florence Slits, Quentin Gex, Vaihere Delaune, Lorenzo A Orci, Yohan van de Looij, Didier J Colin, Stéphane Germain, Claudio de Vito, Laura Rubbia-Brandt, Stéphanie Lacotte, Christian Toso   +12 more
doaj   +1 more source

Artificial Intelligence in Xenotransplantation: A Prioritized Roadmap for Early Clinical Translation, Opportunities and Challenges

Xenotransplantation, Volume 33, Issue 5, September/October 2026.
ABSTRACT Xenotransplantation represents a potential solution to the persistent global organ shortage, yet its clinical application remains stalled by complex immunologic responses, coagulation dysregulation, species‐specific biology, and infectious risks.
Kasra Shirini, Zoe Hahn, Joseph M. Ladowski, Alexander Schulick, Saghar Babadi, Alexandre Loupy, Kazuhiko Yamada, Raphael P. H. Meier   +7 more
wiley   +1 more source

Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys

, 2017
Anti-CD31 antibody conjugation can enhance nanoparticle accumulation in the vascular endothelium of human kidneys during ex vivo normothermic machine perfusion.
Kourosh Saeb-Parsy, John R. Bradley, Jan R. Kraehling, Gregory T. Tietjen, Jordan S. Pober, Sathia Thiru, Nancy C. Kirkiles-Smith, Jenna DiRito, Eric Song, W. Mark Saltzman, Deeksha Deep, Jiajia Cui, Sarah A. Hosgood, Alexandra S. Piotrowski-Daspit, J. Andrew Bradley, Michael L. Nicholson, Rafia Al-Lamki   +16 more
core   +1 more source

From Transplantology to Organ Medicine: When the Organ Becomes an Independent Platform

Organ Medicine, EarlyView.
Qiang Zhang, Zhiyong Guo, Xiaomin Shi, Guodong Chen, Xiaoshun He   +4 more
wiley   +1 more source

Xenotransplantation of the Porcine Lung—From Immunological Barriers to Emerging Experimental Strategies

Xenotransplantation, Volume 33, Issue 5, September/October 2026.
ABSTRACT Lung transplantation is the only long‐lasting life‐saving treatment for patients with end‐stage pulmonary disease, but the ever‐growing shortage of suitable donor organs leads to high mortality rates of the afflicted patients. Xenotransplantation, the transplantation of organs across species, has emerged as a promising alternative. This review
Nathalie Roters, Niveditha Varma, Robert Ramm, Heiner Niemann, Patrick Zardo, Arjang Ruhparwar, Tobias Goecke   +6 more
wiley   +1 more source

Transplantation of discarded livers following viability testing with normothermic machine perfusion

Nature Communications, 2020
The shortage of viable donated livers limits patient access to liver transplantation. Here the authors report the use of normothermic machine perfusion to help identify viable organs from livers discarded based on current clinical criteria, which are ...
Hynek Mergental, Richard W. Laing, Amanda J. Kirkham, M. Thamara P. R. Perera, Yuri L. Boteon, Joseph Attard, Darren Barton, Stuart Curbishley, Manpreet Wilkhu, Desley A. H. Neil, Stefan G. Hübscher, Paolo Muiesan, John R. Isaac, Keith J. Roberts, Manuel Abradelo, Andrea Schlegel, James Ferguson, Hentie Cilliers, Julian Bion, David H. Adams, Chris Morris, Peter J. Friend, Christina Yap, Simon C. Afford, Darius F. Mirza   +24 more
doaj   +1 more source

Flavin Mononucleotide as a Biomarker of Organ Quality—A Pilot Study

Transplantation Direct, 2020
Background. Flavin mononucleotide (FMN), released from damaged mitochondrial complex I during hypothermic liver perfusion, has been shown to be predictive of 90-day graft loss. Normothermic machine perfusion (NMP) and normothermic regional perfusion (NRP)
Lu Wang, MRCS, Emily Thompson, MRCS, Lucy Bates, BSc, Thomas L. Pither, BSc, Sarah A. Hosgood, PhD, Michael L. Nicholson, DSc, Christopher J.E. Watson, MD, Colin Wilson, PhD, Andrew J. Fisher, PhD, Simi Ali, PhD, John H. Dark, FRCS   +10 more
doaj   +1 more source

Ex-Vivo Perfusion of Limb Vascularized Composite Allotransplants: A Systematic Review of Published Protocols

Transplant International
Vascularized composite allotransplantation (VCA) has revolutionized restorative surgery of devastating injuries. Unfortunately, these grafts undergo significant injury during prolonged cold ischemia and subsequent reperfusion.
Tessa E. Muss, Eleni M. Drivas, Amanda H. Loftin, Amanda H. Loftin, Yinan Guo, Yichuan Zhang, Christopher D. Lopez, Alisa O. Girard, Alisa O. Girard, Isabel V. Lake, Bashar Hassan, Bashar Hassan, Richa Kalsi, Byoung Chol Oh, Gerald Brandacher, Gerald Brandacher   +15 more
doaj   +1 more source

Dynamic conditioning of porcine kidney grafts with extracellular vesicles derived from urine progenitor cells: A proof‐of‐concept study

Clinical and Translational Medicine
Among strategies to limit ischemia/reperfusion (IR) injuries in transplantation, cell therapy using stem cells to condition/repair transplanted organs appears promising.
Perrine Burdeyron, Sébastien Giraud, Maryne Lepoittevin, Nina Jordan, Sonia Brishoual, Maïté Jacquard, Virginie Ameteau, Nadège Boildieu, Estelle Lemarie, Jonathan Daniel, Frédéric Martins, Nicolas Mélis, Marine Coué, Raphaël Thuillier, Henri Leuvenink, Luc Pellerin, Thierry Hauet, Clara Steichen   +17 more
doaj   +1 more source