Results 81 to 90 of about 1,873,770 (160)

Use of ex vivo normothermic machine perfusion after normothermic regional perfusion to salvage a poorly perfused DCD kidney.

, 2020
Normothermic regional perfusion (NRP) and normothermic machine perfusion (NMP) have both been used in the procurement and conditioning of abdominal organs from donation after circulatory death donors with reported improved outcomes for the recipients ...

core   +2 more sources

Image_4_Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates ex situ innate immune responses.tiff

, 2022
Access to liver transplantation is limited by a significant organ shortage. The recent introduction of machine perfusion technology allows surgeons to monitor and assess ex situ liver function prior to transplantation. However, many donated organs are of
Jennifer Sanders (220666), Megan Heaney (3749158), Philip Gruppuso (13151763), Taylor M. Coe (10818081), Angela Shih (13151760), Korkut Uygun (191959), Sofia Baptista (10983921), Anders Ohman (13151757), Ivy Rosales (8828036), Reinier J. de Vries (11614378), Siavash Raigani (8067239), James F. Markmann (7144295), Heidi Yeh (301202), John Santiago (13151754)   +13 more
core   +1 more source

Repair or Prevent - What is the real impact of normothermic machine perfusion in liver transplantation?

, 2019
We read with great interest the paper by Jassem et al(1), which provides detailed gene expression profiles of human livers during normothermic machine perfusion (NMP), compared to conventional cold storage.
Schlegel, A, Philipp Dutkowski, Andrea Schlegel, Dutkowski, Philipp, Dutkowski, P, Schlegel, Andrea; https://orcid.org/   +5 more
core   +1 more source

Transplantation of high-risk donor livers after resuscitation and viability assessment using a combined protocol of oxygenated hypothermic, rewarming and normothermic machine perfusion: study protocol for a prospective, single-arm study (DHOPE-COR-NMP trial)

BMJ Open, 2019
Introduction Extended criteria donor (ECD) livers are increasingly accepted for transplantation in an attempt to reduce the gap between the number of patients on the waiting list and the available number of donor livers.
Yvonne de Vries, Tim A Berendsen, Masato Fujiyoshi, Aad P van den Berg, Hans Blokzijl, Marieke T de Boer, Frans van der Heide, Ruben H J de Kleine, Otto B van Leeuwen, Alix P M Matton, Maureen J M Werner, Ton Lisman, Vincent E de Meijer, Robert Porte   +13 more
doaj   +1 more source

The Top Five Advances in Solid Organ Transplantation in the Past Fifty Years

World Journal of Surgery, Volume 50, Issue 8, Page 2121-2124, August 2026.
Stephen J. Wigmore, Diana A. Wu
wiley   +1 more source

Biochemical Composition of Perfusion Fluid and Bile after 6 hour of Ex Vivo Normothermic Machine Perfusion.

, 2014
* To convert values for glucose to mg/dL, multiply by 18.02. To convert values for lactate to mg/dL, multiply by 9.01. To convert values for hemoglobin to g/dL, multiply by 1.650. To convert the value for bilirubin to mg/dL, divide by 17.1.
Negin Karimian (523239), Sanna op den Dries (523237), Henri G. D. Leuvenink (167159), Pepijn D. Weeder (654589), Annette S. H. Gouw (523242), Ton Lisman (46337), Robert J. Porte (447490), Marieke T. de Boer (523240), Michael E. Sutton (523238), Janneke Wiersema-Buist (523241)   +9 more
core   +1 more source

Outcome reporting for liver transplantation machine perfusion studies: a systematic reviewResearch in context

EClinicalMedicine
Summary: Background: Studies examining machine perfusion (MP) in liver transplantation (LT) report variable post-transplant outcomes, making comparison difficult.
Sangeeta Satish, Ayesha A. Qureshi, Fariba Abbassi, Muhammad A. Nadeem, Tobias Diwan, Laura Batista De Oliveira, Charles Miller, Koji Hashimoto, Chase J. Wehrle, Pierre-Alain Clavien, Andrea Schlegel   +10 more
doaj   +1 more source

Experimental Evaluation of a New Perfusion Machine Using Normothermic Cycles on Explanted Livers

IEEE Open Journal of Engineering in Medicine and Biology
Goal: Organ perfusion is a vast subject with several techniques, the most common being Hypothermic Machine Perfusion (HMP) and Normothermic Machine Perfusion (NMP).
Eleonora Barcali, Lorenzo Maggi, Rebecca Panconesi, Fabio Staderini, Leonardo Bocchi, Cosimo Nardi, Nadia Navari, Adriano Peris, Matteo Risaliti, Mauricio F. Carvalho, Fabio Marra, Philipp Dutkowski, Gian Luca Grazi, Andrea Schlegel, Filippo Bigi, Mattia Dimitri, Andrea Corvi   +16 more
doaj   +1 more source

Normothermic human kidney preservation drives iron accumulation and ferroptosis

Nature Communications
Ex vivo normothermic machine perfusion has been proposed to protect deceased donor kidneys. However, its benefits remain ambiguous. We postulate that the use of red blood cells (RBCs) and associated secondary hemolysis may in fact cause renal injury ...
Marlon J. A. de Haan, Marleen E. Jacobs, Annemarie M. A. de Graaf, Roan H. van Scheppingen, Rico J. E. Derks, Dorottya K. de Vries, Jesper Kers, Ian P. J. Alwayn, Cees van Kooten, Elena Sánchez-López, Martin Giera, Marten A. Engelse, Ton J. Rabelink   +12 more
doaj   +1 more source

Secondary Perfusion to Model Viability of Livers Declined for Transplantation

Livers
Background/Objectives: The donor liver shortage has created an urgent need to utilize higher-risk grafts for transplantation. Normothermic machine perfusion enables ex vivo graft assessment prior to transplantation, offering a route to expand access ...
Avery K. Fortier, Kimberly M. Feeney, Matthew L. Holzner, Joseph DiNorcia, Ron Shapiro, Leona Kim-Schluger, Sander S. Florman, L. Leonie van Leeuwen, M. Zeeshan Akhtar   +8 more
doaj   +1 more source