Results 11 to 20 of about 1,873,770 (160)

Viability Criteria during Liver Ex-Situ Normothermic and Hypothermic Perfusion [PDF]

Medicina, 2022
With the increased use of extended-criteria donors, machine perfusion became a beneficial alternative to cold storage in preservation strategy for donor livers with the intent to expand donor pool. Both normothermic and hypothermic approach achieved good
Fabio Melandro, Riccardo De Carlis, Francesco Torri, Andrea Lauterio, Paolo De Simone, Luciano De Carlis, Davide Ghinolfi   +6 more
doaj   +2 more sources

A fully automated normothermic machine perfusion system for kidney grafts supporting physiological motivated flow profiles

Current Directions in Biomedical Engineering, 2023
Research showed that the normothermic machine perfusion of kidneys can enable prolonged storage and improve conditions compared to traditional cold storage. For research in this area, there is a demand for a long-term in vitro perfusion setup.
Wiartalla Marc, Berg Frederik, Kühn Jahn, Buglowski Mateusz, Bleilevens Christian, Kowalewski Stefan, Stollenwerk André   +6 more
doaj   +2 more sources

Advances in Xenotransplantation: Evaluation of αGal-KO Porcine Livers and Lungs Using Normothermic Machine Perfusion in a Collaborative Perfusion Hub [PDF]

Transplant International
Recently, initial clinical experience has been gained with the xenotransplantation of pig organs such as heart and kidney into terminally ill human patients in an effort to overcoming organ shortage.
S. Stoerzer, S. Kruszona, P. Wand, H. Linge, H. Zlatev, K. Hoeffler, K. Hoeffler, J. Singh, N. Roters, N. Roters, V. Muth, S. Tavil, A. Saipbaev, A. Saipbaev, K. Cvitkovic, K. Cvitkovic, W. A. Kues, P. Zardo, P. Zardo, P. Zardo, F. Ius, F. Ius, J. Mengwasser, K. Splith, K. M. Schmidt-Ott, T. Goecke, T. Goecke, T. Goecke, R. Schwinzer, H. Niemann, A. Ruhparwar, A. Ruhparwar, A. Ruhparwar, M. Schmelzle, R. Ramm, R. Ramm, R. Ramm, P. Felgendreff   +37 more
doaj   +4 more sources

Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates ex situ innate immune responses [PDF]

Frontiers in Immunology, 2022
Access to liver transplantation is limited by a significant organ shortage. The recent introduction of machine perfusion technology allows surgeons to monitor and assess ex situ liver function prior to transplantation. However, many donated organs are of
Siavash Raigani, Siavash Raigani, John Santiago, Anders Ohman, Megan Heaney, Sofia Baptista, Sofia Baptista, Taylor M. Coe, Reinier J. de Vries, Ivy Rosales, Angela Shih, James F. Markmann, James F. Markmann, Philip Gruppuso, Korkut Uygun, Korkut Uygun, Jennifer Sanders, Heidi Yeh   +17 more
doaj   +2 more sources

A reproducible extended ex-vivo normothermic machine liver perfusion protocol utilising improved nutrition and targeted vascular flows [PDF]

Communications Medicine
Background Normothermic machine perfusion of donor livers has become standard practice in the field of transplantation, allowing the assessment of organs and safe extension of preservation times.
George Clarke, Jingwen Mao, Angus Hann, Yiyu Fan, Amita Gupta, Anisa Nutu, Erwin Buckel Schaffner, Kayani Kayani, Nicholas Murphy, Mansoor N. Bangash, Anna L. Casey, Isla Wootton, Alexander J. Lawson, Bobby V. M. Dasari, M. Thamara P. R. Perera, Hynek Mergental, Simon C. Afford   +16 more
doaj   +2 more sources

Acellular Perfusate is an Adequate Alternative to Packed Red Blood Cells During Normothermic Human Kidney Perfusion

Transplantation Direct
Background. Brief normothermic machine perfusion is increasingly used to assess and recondition grafts before transplant. During normothermic machine perfusion, metabolic activity is typically maintained using red blood cell (RBC)–based solutions ...
Alban Longchamp, MD, PhD, Fermin M. Fontan, MD, Mohamed M. Aburawi, MD, Corey Eymard, MD, Negin Karimian, MD, PhD, Danielle Detelich, MD, Casie Pendexter, BS, Stephanie Cronin, MS, Thomas Agius, MS, Sonal Nagpal, MBA, Peony Dutta Banik, BS, Shannon N. Tessier, PhD, Sinan Ozer, MBA, Francis L. Delmonico, MD, Korkut Uygun, PhD, Heidi Yeh, MD, James F. Markmann, MD, PhD   +16 more
doaj   +2 more sources

Viability assessment and transplantation of fatty liver grafts using end‐ischemic normothermic machine perfusion

Liver Transplantation, EarlyView., 2022
Abstract End‐ischemic viability testing by normothermic machine perfusion (NMP) represents an effective strategy to recover liver grafts having initially been discarded for liver transplantation (LT). However, its results in the setting of significant (≥30%) macrovesicular steatosis (MaS) have not been specifically assessed.
Damiano Patrono, Riccardo De Carlis, Alessandro Gambella, Francesca Farnesi, Alice Podestà, Andrea Lauterio, Francesco Tandoi, Luciano De Carlis, Renato Romagnoli   +8 more
wiley   +1 more source

Ex situ Normothermic Split Liver Machine Perfusion: Protocol for Robust Comparative Controls in Liver Function Assessment Suitable for Evaluation of Novel Therapeutic Interventions in the Pre-clinical Setting

Frontiers in Surgery, 2021
Background:Ex situ donor liver machine perfusion is a promising tool to assess organ viability prior to transplantation and platform to investigate novel therapeutic interventions.
Joseph A. Attard, Joseph A. Attard, Joseph A. Attard, Daniel-Clement Osei-Bordom, Daniel-Clement Osei-Bordom, Yuri Boteon, Yuri Boteon, Yuri Boteon, Lorraine Wallace, Lorraine Wallace, Vincenzo Ronca, Vincenzo Ronca, Gary Reynolds, Gary Reynolds, M. T. P. R. Perera, Ye Htun Oo, Ye Htun Oo, Ye Htun Oo, Ye Htun Oo, Hynek Mergental, Hynek Mergental, Hynek Mergental, Darius F. Mirza, Simon C. Afford, Simon C. Afford   +24 more
doaj   +1 more source

Hypothermic, oxygenated perfusion (HOPE) provides cardioprotection via succinate oxidation prior to normothermic perfusion in a rat model of donation after circulatory death (DCD) [PDF]

, 2021
In donation after circulatory death (DCD), cardiac grafts are subjected to warm ischemia in situ, prior to a brief period of cold, static storage (CSS) at procurement, and ex situ, normothermic, machine perfusion (NMP) for transport and graft evaluation.
Arnold, Maria, Wyss, Rahel K., Segiser, Adrian, Carrel, Thierry P, Carrel, Thierry P., Mueller, Matteo, Longnus, Sarah L; https://orcid.org/, Dutkowski, Philipp, Wyss, Rahel K, Longnus, Sarah L., Méndez Carmona, Natalia   +10 more
core   +1 more source

The Current Role and Future Applications of Machine Perfusion in Liver Transplantation

Bioengineering, 2023
The relative paucity of donor livers suitable for transplantation has sparked innovations to preserve and recondition organs to expand the pool of transplantable organs.
Sebastian M. Staubli, Carlo D. L. Ceresa, Joerg M. Pollok   +2 more
doaj   +1 more source