Results 31 to 40 of about 16,770 (217)

A Novel Rat Model of Cardiac Donation After Circulatory Death Combined With Normothermic ex situ Heart Perfusion

Frontiers in Cardiovascular Medicine, 2021
Background: In heart transplantation, the adoption of hearts from donation after circulatory death (DCD) is considered to be a promising approach to expanding the donor pool. Normothermic ex situ heart perfusion (ESHP) is emerging as a novel preservation
Jiale Li, Chuqing Xue, Xiao Ling, Yu Xie, Desai Pavan, Huimin Chen, Qinbao Peng, Shaoyan Lin, Kunsheng Li, Shaoyi Zheng, Pengyu Zhou   +10 more
doaj   +1 more source

Combined Hypothermic and Normothermic Machine Perfusion Improves Functional Recovery of Extended Criteria Donor Livers [PDF]

, 2018
Hypothermic oxygenated perfusion (HOPE) and normothermic perfusion are seen as distinct techniques of ex situ machine perfusion of the liver. We aimed to demonstrate the feasibility of combining both techniques and whether it would improve functional ...
Darius F. Mirza, Afford, Simon C, Wallace, Lorraine, Hynek Mergental, Mirza, Darius F, Andrea Schlegel, Attard, Joseph, Laing, Richard W, Joseph Attard, Richard W. Laing, M. Thamara P. R. Perera, Simon C. Afford, Bhogal, Ricky H, Desley A. H. Neil, Smith, Amanda, Yuri L. Boteon, Stefan Hübscher, Neil, Desley A H, Hübscher, Stefan, Ricky H. Bhogal, Boteon, Yuri L, Perera, M Thamara P R, Mergental, Hynek, Amanda Smith, Schlegel, Andrea, Lorraine Wallace   +25 more
core   +1 more source

Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation

EBioMedicine, 2020
Background: Mitochondrial succinate accumulation has been suggested as key event for ischemia reperfusion injury in mice. No specific data are however available on behavior of liver mitochondria during ex situ machine perfusion in clinical transplant ...
Andrea Schlegel, Xavier Muller, Matteo Mueller, Anna Stepanova, Philipp Kron, Olivier de Rougemont, Paolo Muiesan, Pierre-Alain Clavien, Alexander Galkin, David Meierhofer, Philipp Dutkowski   +10 more
doaj   +1 more source

Normothermic Perfusion

Annals of Surgery, 2009
Transplantation of organs retrieved after cardiac arrest could increase the donor organ supply. However, the combination of warm ischemia and cold preservation is highly detrimental to the reperfused organ. Our objective was to maintain physiological temperature and organ function during preservation and thereby alleviate this injury and allow ...
Brockmann, J, Reddy, S, Coussios, C, Pigott, D, Guirriero, D, Hughes, D, Morovat, A, Roy, D, Winter, L, Friend, P   +9 more
openaire   +2 more sources

Successful transplantation of porcine liver grafts following 48-hour normothermic preservation.

PLoS ONE, 2017
Current cold storage organ preservation technique fails to preserve marginal donor grafts sufficiently. Evidence from large animal experiments suggests superiority of normothermic machine preservation of liver allografts.
Thomas Vogel, Jens G Brockmann, David Pigott, Desley A H Neil, Anand S Rathnasamy Muthusamy, Constantin C Coussios, Peter J Friend   +6 more
doaj   +1 more source

Experimental Evaluation of a New Perfusion Machine Using Normothermic Cycles on Explanted Livers

IEEE Open Journal of Engineering in Medicine and Biology
Goal: Organ perfusion is a vast subject with several techniques, the most common being Hypothermic Machine Perfusion (HMP) and Normothermic Machine Perfusion (NMP).
Eleonora Barcali, Lorenzo Maggi, Rebecca Panconesi, Fabio Staderini, Leonardo Bocchi, Cosimo Nardi, Nadia Navari, Adriano Peris, Matteo Risaliti, Mauricio F. Carvalho, Fabio Marra, Philipp Dutkowski, Gian Luca Grazi, Andrea Schlegel, Filippo Bigi, Mattia Dimitri, Andrea Corvi   +16 more
doaj   +1 more source

The association between early hemodynamic variables and outcome in normothermic comatose patients following cardiac arrest

, 2010
Currently, few data exist on the association between post-cardiac arrest hemodynamic function and outcome. In this explorative, retrospective analysis, the association between hemodynamic variables during the first 24 h after intensive care unit ...
Schmittinger, C A, Jakob, S M, Dünser, M W, C. TORGERSEN, S. M. JAKOB, J. TAKALA, M. W. DÜNSER, Takala, J, C. A. SCHMITTINGER, Torgersen, C   +9 more
core   +1 more source

Advancements in ex vivo machine perfusion for abdominal organ transplantation

Frontiers in Transplantation
Organ transplantation remains the definitive treatment for end-stage organ failure, yet its impact continues to be constrained by a persistent shortage of suitable donor organs.
Danae G. Olaso, Victoria A. Bendersky, Wyeth D. Alexander, Aleah L. Brubaker, Peter A. Than, Gabriel T. Schnickel   +5 more
doaj   +1 more source

POST-SURGERY CHANGES IN THE RATES OF ACID-BASE BALANCE AND BLOOD GAS CONTENT IN SURGICAL TREATMENT OF ACQUIRED CARDIAC DEFECTS UNDER CONDITIONS OF NORMAL AND HYPOTHERMIC CARDIOPULMONARY BYPASS

Вестник анестезиологии и реаниматологии, 2017
The purpose of this study is to assess changes in the rates of acid-base balance in adult cardiac surgery patients with acquired cardiac defects who were operated using hypo- and normothermic cardiopulmonary bypass.
V. V. Lomivorotov, V. A. Shmyrev, S. M. Efremov, D. N. Ponomaryov, G. B. Moroz, I. A. Kornilov, A. N. Shilova, V. N. Lomivorotov, D. G. Shakhin, D. V. Shmatov, D. V. Shmatov   +10 more
doaj   +1 more source

Normothermic Machine Perfusion (NMP) Inhibits Proinflammatory Responses in the Liver and Promotes Regeneration

, 2019
Liver transplantation (LT) is a successful treatment for patients with liver failure. However, organ shortage results in over 11% of patients losing their chance of a transplant attributed to liver decompensation (LD) and death.
Jassem, W., Xystrakis, E., Sanchez-Fueyo, A., Lozano, J.J., Jabri, Y., Huang, X., Ma, Y., Coussios, C.C., Rela, M., Martinez-Llordella, M., Quaglia, A., Ghnewa, Y.G., Yuksel, M., Friend, P., Heaton, N., Pop, O.   +15 more
core   +1 more source