Results 131 to 140 of about 4,789,647 (304)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Testing the Rational Expectations Hypothesis using Survey Data [PDF]
Because of the importance of inflation expectations, Lloyd B. Thomas Jr. (Fall 1999, p. 125-44) reexamines "the evidence on the nature and performance of various measures of expected inflation, with special attention given to the issue of rationality" (p.
Richard H Cohen, Carl S Bonham
core
Testing the Gateway Hypothesis [PDF]
Neuropsychopharmacology, 2017 Michael L Miller, Yasmin L Hurd
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A critical analysis of the role of statistical significance testing in education research: With special attention to mathematics education [PDF]
, 2005 This study analyzes the role of statistical significance testing (SST) in education. Although the basic logic underlying SST 一 a hypothesis is rejected because the observed data would be very unlikely if the hypothesis is true 一 appears so obvious that ...
Ng, Yui-kin, Yui-kin Ng,
core
On Bayes factors for hypothesis tests
Psychonomic Bulletin & ReviewAbstract We develop alternative families of Bayes factors for use in hypothesis tests as alternatives to the popular default Bayes factors. The alternative Bayes factors are derived for the statistical analyses most commonly used in psychological research – one-sample and two-sample t tests, regression, and ANOVA analyses.
Karl Christoph Klauer +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source