Results 111 to 120 of about 145 (139)

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Artificial Intelligence‐Based Body Composition Analysis Reveals Sex‐Specific Prognostic Markers and Their Clinical Value in Gastric Cancer: A Multicenter Study

Advanced Science, EarlyView.
This study applied AI to quantify multidimensional body composition from CT images in gastric cancer and healthy controls. Distinct sex‐specific patterns and disease‐related alterations were identified and were associated with survival. Higher muscle and fat measures were linked to improved outcomes.
Tianxiang Li, Tingting Liu, Qian Yang, Zhiqing Zhang, Xiaofang Guo, Xiang Wang, Yihan Zhang, Limin Ge, Yu Su, Wenjun Wu, Weihua Guo, Zheng Wang, Lian Yang, Yanfeng Niu   +13 more
wiley   +1 more source

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

Advanced Science, EarlyView.
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma, Pengcheng Yao, Shengqi Wu, Yuanyuan Shi, Lang Qin, Baitao Li, Jiayi Zhu, Minhua Huang, Yichong Zhu, Yuwen Song, Jinhuan Pang, Ziping Guo, Guochuan Wu, Chen Wang, Kewei Xu, Ruihua Huang, Quan Kuang, Liang Qu, Changtian Pan, Xianrong Xie, Qinlong Zhu, Jiaying Huang, Qiupeng Lin   +22 more
wiley   +1 more source

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Hypothetical Modality

Studies in Language Companion Series, 2000
This book marks a new development in the field of grammaticalisation studies, in that it extends the field of grammaticalisation studies from relatively homogeneous languages to those possessing well-established and institutionalised second language varieties.
Debra Ziegeler
openaire   +4 more sources

Answers to modal and hypothetical questions in knowledge base systems

Applied Intelligence, 1992
This paper describes a computational model which is geared towards providing helpful answers to modal and hypothetical questions in knowledge base systems (KBSs). The model is an essential component of a more complete model which aims at giving helpful answers to questions presented in a natural language.
Nadim Obeid, Obeid Nadim
openaire   +3 more sources

Review of Ziegeler (2000): Hypothetical Modality. Grammaticalisation in an L2 Dialect

Journal of Historical Pragmatics, 2002
Roberta Facchinetti
openaire   +3 more sources

2. Hypothetical modality as a grammatical category

Studies in Language Companion Series, 2000
openaire   +3 more sources

4. Singaporean English and substratum influences in the grammaticalisation of hypothetical modality

Studies in Language Companion Series, 2000
openaire   +3 more sources

A modal extension of logic programming: modularity, beliefs and hypothetical reasoning

Journal of Logic and Computation, 1998
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
M. BALDONI, A. MARTELLI, GIORDANO, Laura
openaire   +2 more sources

Aspects of the grammaticalisation of hypothetical modality

2021
This thesis was scanned from the print manuscript for digital preservation and is copyright the author. Researchers can access this thesis by asking their local university, institution or public library to make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
openaire   +1 more source