Results 11 to 20 of about 145 (139)
The Use of the Lexical Exponents of Hypothetical Modality in Polish and Lithuanian
Cognitive Studies | Études cognitives, 2016 The Use of the Lexical Exponents of Hypothetical Modality in Polish and LithuanianIn this article the author focuses on the issue of hypothetical modality[1] in Polish and Lithuanian. A list of the basic exponents of hypothetical modality in both languages is presented. However, the focus is mainly placed on the lexical exponents.
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
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Could Have, Should Have, Would Have. The Speaker’s Attitude in Expressing Hypothetical Past Alternatives in English and Italian by Means of Pragmatic Markers and Modality in EU Parliamentary Debates. [PDF]
Studies About Languages, 2018 Legislation and important decisions affecting the lives of over 400 million European citizens are discussed on a regular basis in the European Parliament debates. This research paper analyzes the MEPs’ speeches in terms of the co-occurrence of past conditionals and pragmatic markers signalling the speaker’s attitude to the propositional meaning ...
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
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Lexical exponents of hypothetical modality in Polish and Lithuanian
Cognitive Studies | Études cognitives, 2015 Lexical exponents of hypothetical modality in Polish and LithuanianThe article focuses on the lexical exponents of hypothetical modality in Polish and Lithuanian. The purpose for comparing and contrasting the lexical exponents of hypothetical modality is not only to identify all the lexemes in both languages but also find the answer to the following ...
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
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FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
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