Results 141 to 150 of about 47,885 (247)

Intersection of systemic lupus erythematosus and autoimmune thyroid disease: Shared pathophysiology, epidemiology, diagnosis, and management

Rheumatology &Autoimmunity, EarlyView.
A proposed mechanistic framework of systemic lupus erythematosus (SLE) and autoimmune thyroid disease (AITD) pathogenesis. In Stage 1, genetically susceptible individuals harbor risk variants within major histocompatibility complex (HLA) and non‐HLA loci that impair central and peripheral immune tolerance mechanisms within the thymic and peripheral ...
Elisa Elisa, Awalia Awalia, Deasy Ardiany, Henry Sutanto   +3 more
wiley   +1 more source

[Should we screen and treat subclinical hypothyroidism?]

, 2012
Subclinical hypothyroidism, defined as an elevated thyroid stimulating hormone and normal thyroxine level, is common with aging, particularly after 65 years old. This condition is potentially associated with important consequences, such as cardiovascular
Virgini, Vanessa, Collet, Tinh-Hai, Aujesky, Drahomir, Rodondi, Nicolas, Christ, Emanuel   +4 more
core  

Breast Skin Lesions in a 79‐Year‐Old Woman

JEADV Clinical Practice, EarlyView.
Javier Lorenz‐Dolz, Fátima Mayo‐Martínez, Andrea Díez Santandreu, Onofre Sanmartín Jiménez, Ruggero Moro   +4 more
wiley   +1 more source

Antimicrobial Residues in a Key Cerrado River: Distribution, Persistence, and Effects on Zebrafish Embryo‐Larval Development

Environmental Toxicology, EarlyView.
ABSTRACT The current study aimed to quantify the antimicrobials amoxicillin (AMX), cefazolin (CFZ), chloramphenicol (CHL), metronidazole (MTZ), and sulfamethoxazole (SX) in effluents and surface water of an important Cerrado river, calculate their half‐lives, and analyze their ecotoxicity following single and combined exposures.
Náthala Maria Simão, Igor Romeiro dos Santos, Jerônimo Raimundo de Oliveira Neto, Flávio Olimpio Sanches Neto, Felipe Cirqueira Dias, Jéssyca Moreira Morais, Lorranny Pereira de Assis Valadares, Naiara Raica Lopes de Oliveira, Mirelle Garcia Silva Bailão, Luiz Carlos da Cunha, Valter Henrique Carvalho‐Silva, Thiago Lopes Rocha, Elisa Flávia Luiz Cardoso Bailão   +12 more
wiley   +1 more source

Microplastics and the Endocrine–Metabolic Interface: Novel Diagnostic Tools Targeting Thyroid–Adipose Axis

Environmental Toxicology, EarlyView.
ABSTRACT Microplastics (MPs) have been identified as major environmental contaminants that can affect organisms directly and act as carriers of particles and chemical additives, thereby aggravating endocrine networks that coordinate metabolic homeostasis.
Sunday Amos Onikanni, Babasola Aiyeku, Marjorie Dardis Murucci, Temitope Aribigbola, Kenia Bispo, Oluwatosin Stella Olayinka, Rômulo Sperduto Dezonne, Sara Gemini Piperni, Paula Soares, Denise Pires de Carvalho, Leandro Miranda‐Alves   +10 more
wiley   +1 more source

Amenamevir Transfer into Breast Milk in Patients with Herpes Simplex Virus Infection: A Brief Report of a Prospective Multicenter Study

The Journal of Dermatology, EarlyView.
ABSTRACT Patient–initiated therapy (PIT) is a treatment approach in which patients with recurrent herpes simplex self–administer medication at the onset of prodromal symptoms. PIT, which allows patients to receive medication in advance and initiate treatment at any time, is a therapeutic approach that alleviates the burden of urgent clinic visits for ...
Sachi Koinuma, Mikako Goto, Jumpei Saito, Hiroaki Aoki, Satoshi Hayashi, Tomoyoshi Takeshita   +5 more
wiley   +1 more source

Effect of Anti‐IL‐23 and Anti‐IL‐17 Therapy on Darier Disease: A Case Series

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Darier disease is a rare ATP2A2‐related genodermatosis for which therapeutic options remain limited, as acitretin is often constrained by toxicity and teratogenicity. In this retrospective real‐world case series of eight patients, anti‐IL‐17 therapy showed a more consistent early signal of clinical benefit than anti‐IL‐23 therapy, with greater
Maione Vincenzo, Zanghi Silvia, Catapano Cecilia, Bighetti Stefano, Cattaneo Isacco, Venturini Marina, Bettolini Luca   +6 more
wiley   +1 more source

Intra‐operative hypotension threshold models and subdistribution hazard of postoperative pneumonia in patients having non‐cardiac surgery

Anaesthesia, EarlyView.
Summary Introduction Intra‐operative hypotension is common during general anaesthesia, but its association with postoperative pneumonia remains uncertain, partly because hypotension has been defined using different thresholds. We evaluated whether absolute thresholds or relative reductions from baseline mean arterial pressure were associated more ...
Pingping Wang, Junming Gu, Yanyu Liu, Jing Zhuang, Shengkun Peng, Qian Xiang, Minhong Cai, Xiaobin Liu, Yu Lv   +8 more
wiley   +1 more source

6‐Nitrodopamine as a Novel Mediator of Prostatic Smooth Muscle Function in Mouse and Human

Andrology, EarlyView.
ABSTRACT Background Epithelium‐derived catecholamines contribute to local regulation of genitourinary smooth muscle function, but the role of the endogenous 6‐nitrodopamine (6‐ND) in the prostate remains unknown. Objectives To determine whether 6‐ND is produced by mouse and human prostate and its role in smooth muscle regulation.
Alline Araujo Curiel, Fabio Henrique da Silva, Jéssica Mariana Dias, Luise Gabriela Santos Pereira, Douglas Rafael Martins Dias, Amanda Bueno Olivotti, André Almeida Schenka, Valéria Barbosa de Souza, Masato Tsutsui, Fabiola Zakia Monica, Edson Antunes, Gilberto De Nucci, Mariana G. de Oliveira   +12 more
wiley   +1 more source

Investigating the Use of Routine Swabs in Incision and Drainage of Abscesses: An Audit of Western Sydney Hospitals

ANZ Journal of Surgery, EarlyView.
This study aimed to demonstrate whether intraoperative swab results were used to tailor antibiotic management in incision and drainage of abscesses. A retrospective cohort study was performed from 2023 to 2025, with 2088 cases. In most cases, an intraoperative swab was collected. The result only changed antibiotic management in 3% of cases.
Bethany Rachel O'Neill, Amy Hort, Lynne Mann   +2 more
wiley   +1 more source