Results 41 to 50 of about 11,822 (153)

Open‐Label, Balanced, Randomized, Single‐Dose, Three‐Treatment, Three‐Sequence, Three‐Period, Three‐Way Crossover Oral Bioequivalence Study of Desmopressin Acetate Oral Solution

Clinical Pharmacology in Drug Development, Volume 15, Issue 8, August 2026.
ABSTRACT Desmopressin is first‐line therapy for central diabetes insipidus, also known as arginine vasopressin deficiency, but presents dosing challenges due to its narrow therapeutic index. This open‐label, randomized, three‐way crossover study evaluated the bioequivalence of a new desmopressin acetate oral solution (50 mcg/mL) compared to ...
Adam Christensen, Axay Parth, Mansi Kotak, Danka Radosavjevic, Catherine Gorman Moore, Byung‐Woun Seo   +5 more
wiley   +1 more source

Gestational diabetes insipidus. A systematic review of case reports

Journal of Perinatal Medicine
To evaluate the clinical characteristics and etiopathogenic factors associated with gestational diabetes insipidus (GDI), analyzing maternal and perinatal outcomes.
González Mónica Bermúdez, Silvares Esther Alvarez, Pérez Gonzalo Rubio   +2 more
doaj   +1 more source

Diabetes mellitus associado a dermatopatia em cão: relato de caso Diabetes mellitus associated with dermatopathy in a dog: case report

Ciência Rural, 1997
Relata-se o caso de um canino, Poodle, fêmea de 12 anos, apresentando poliúria, polidipsia, polifagia, alopecia progressiva e cegueira. Ao exame clínico, observou-se caquexia, alopecia simétrica bilateral em tronco, dorso, membros e abdômen, pele ...
Mônica Vicky Bahr Arias, Márcia Marques Jericó   +1 more
doaj   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Diabetes insipidus in the diagnosis of polyuria [PDF]

, 2012
Diabetes insipidus is a rare condition, whereas polyuria may be a symptom of numerous other ailments. Polyuria intensifies thirst (polydipsia), which appears to be a natural reaction to an excessive loss of water in the organism.
Kamiński, Michał, Krajnik, Małgorzata, Junik, Roman, Kamińska, Anna, Graczyk, Michał   +4 more
core  

Polydipsia and polyuria by the X-irradiated rat

, 1959
The results of partial-body x-irradiation experiments established the abdomen as the radiosensitive area involved in postirradiation polydipsia and polyuria. However, the responses do not appear to be due to the action of x-rays on any one organ in this
Cecil Entenman, Robert E. Kay
core   +1 more source

Central diabetes insipidus: pathophysiology, diagnosis, and modern approaches to the treatment of antidiuretic hormone deficiency

Лечащий Врач
Background. Polydipsia-polyuria syndrome is characterized by abnormally increased fluid intake by the patient, which often mimics the manifestations of central diabetes insipidus (syn. – antidiuretic hormone deficiency).
E. A. Pigarova, A. S. Savieva, L. K. Dzeranova   +2 more
doaj   +1 more source

Prostaglandin-dependent polyuria in hypercalcemia

, 1981
The present experiments examined the role of prostaglandin biosynthesis in the increase in urine flow rate seen in rats with hypercalcemia induced by the administration of 1,25-dihydroxycholecalciferol.
E. R. Serros, M. A. Kirschenbaum
core   +1 more source

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

A Review of Nanoparticle‐Based Astrocyte Modulation in CNS Disorders: Evaluating the Underexplored Potential of Intranasal Delivery

Nano Select, Volume 7, Issue 1, January 2026.
Nanoparticle‐driven nose‐to‐brain drug delivery offers a noninvasive approach to bypass the blood–brain barrier (BBB) and directly modulate reactive astrocytes in CNS disorders. This review highlights biodegradable nanoparticles for astrocyte modulation, enhancing drug bioavailability, sustained release, and neuroinflammation control.
Senamile M. Dlamini, Gillian D. Mahumane, Pradeep Kumar, Yahya E. Choonara   +3 more
wiley   +1 more source