The Journal of Physiology, EarlyView.Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma +12 more
wiley +1 more source
A Rapid and Specific Method for Separation of Bound and Free Antigen in Radioimmunoassay Systems [PDF]
, 1979 Peer ...
Müller, O. A. +3 more
core +2 more sources
Purification and Characterization of Human Hypoxanthine/Guanine Phosphoribosyltransferase [PDF]
European Journal of Biochemistry, 1977 Human hypoxanthine/guanine phosphoribosyltransferase (EC 2.4.2.8) was purified from red blood cells by the following two methods. Method A includes (a) elimination of hemoglobin by DEAE‐cellulose, (b) DEAE‐Sephadex chromatography, (c) specific elution of the enzyme from CM‐Sephadex by pyrophosphate and (d) Sephadex G‐100 gel filtration.
H, Muensch, A, Yoshida
openaire +2 more sources
British Journal of Pharmacology, Volume 183, Issue 9, Page 2139-2165, May 2026.Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi +14 more
wiley +1 more source
Striatal neurodevelopment is dysregulated in purine metabolism deficiency and impacts DARPP-32, BDNF/TrkB expression and signaling: new insights on the molecular and cellular basis of Lesch-Nyhan Syndrome. [PDF]
PLoS ONE, 2014 Lesch-Nyhan Syndrome (LNS) is a neurodevelopmental disorder caused by mutations in the gene encoding the purine metabolic enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT).
Ghiabe-Henri Guibinga +2 more
doaj +1 more source
In Vivo Biotinylation of the Toxoplasma Parasitophorous Vacuole Reveals Novel Dense Granule Proteins Important for Parasite Growth and Pathogenesis. [PDF]
, 2016 UnlabelledToxoplasma gondii is an obligate intracellular parasite that invades host cells and replicates within a unique parasitophorous vacuole. To maintain this intracellular niche, the parasite secretes an array of dense granule proteins (GRAs) into ...
Bell, Hannah N +7 more
core +2 more sources
Pediatric Blood &Cancer, Volume 73, Issue 4, April 2026.ABSTRACT Introduction Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. The pro‐drug 6‐mercaptopurine (6‐MP), essential during maintenance, is converted into active 6‐thioguanine (6‐TGN) and toxic 6‐methylmercaptopurine (6‐MMP) metabolites, resulting in marked variability in efficacy and toxicity.
Anne Ravix +5 more
wiley +1 more source
Differential impact of drugs on the outcome of ETV6-RUNX1 positive childhood B-cell precursor acute lymphoblastic leukaemia : results of the EORTC CLG 58881 and 58951 trials [PDF]
, 2018 info:eu-repo/semantics ...
Benoit, Yves +30 more
core +2 more sources
Use of Computational Models to Investigate Human Targets of Small Ubiquitous Molecules
ChemBioChem, Volume 27, Issue 8, April 2026.Chemoinformatics and atomistic modeling were combined to identify protein targets of environmentally and occupationally relevant chemical compounds. A public database linking chemicals, genes, phenotypes, and diseases was used for validation. The study highlights the potential and limitations of these fast, low‐cost computational approaches for early ...
Elena Frasnetti +5 more
wiley +1 more source
Medical Laboratory Journal, 2018 Background and Objectives: Non-synonymous single nucleotide polymorphisms are typical genetic variations that may potentially affect the structure or function of expressed proteins, and therefore could be involved in complex disorders.
Semira Kheiri +3 more
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