Results 301 to 310 of about 93,529 (343)

Hypoxanthine Phosphoribosyltransferase and Hypoxanthine Uptake in Human Erythrocytes

Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1975
A system of hypoxanthine uptake and IMP retention was studied and characterized in human erythrocytes. It follows closely the system already described for rabbit erythrocytes[7]. IMP formation and retention are dependent on the activity of hypoxanthine phosphoribosyl-transferase and on intracellular availability of phosphoribosyl pyrophosphate (P-Rib ...
openaire   +3 more sources

Hypoxanthine: a new paradigm to interpret the origin of transfusion toxicity.

Blood transfusion = Trasfusione del sangue, 2015
Dear Sirs, For blood banks, the possibility to store blood components for prolonged periods, preserving their clinical effectiveness, is an issue of paramount relevance for which a reliable solution has not been found, yet.
E. Casali, P. Berni, A. Spisni, R. Baricchi, T. Pertinhez   +4 more
semanticscholar   +1 more source

Na+-independent nucleoside transporters regulate adenosine and hypoxanthine levels in Müller cells and the inner blood-retinal barrier.

Investigative Ophthalmology and Visual Science, 2013
PURPOSE To elucidate the mechanism(s) of hypoxanthine production in Müller cells and the elimination of hypoxanthine across the inner blood-retinal barrier (BRB).
S. Akanuma, Tatsuya Soutome, E. Hisada, M. Tachikawa, Yoshiyuki Kubo, K. Hosoya   +5 more
semanticscholar   +1 more source

Low-potential amperometric enzyme biosensor for xanthine and hypoxanthine.

Analytical Chemistry, 2012
The bacterial xanthine dehydrogenase (XDH) from Rhodobacter capsulatus was immobilized on an edge-plane pyrolytic graphite (EPG) electrode to construct a hypoxanthine/xanthine biosensor that functions at physiological pH. Phenazine methosulfate (PMS) was
P. Kalimuthu, S. Leimkühler, P. Bernhardt   +2 more
semanticscholar   +1 more source

Uptake of Hypoxanthine in Human Erythrocytes

1977
The concentration of oxypurines in the plasma is known to be rather low (10 – 40 μM) (6). Since the formation of purines is accomplished to a great extent by the liver (7, 8), a transport of purines by erythrocytes from liver to tissues with limited or no capacity of de novo purine synthesis has been postulated (1, 3).
G. Falkner, Mathias Müller
openaire   +3 more sources

Amperometric detection of hypoxanthine and xanthine by enzymatic amplification using a gold nanoparticles-carbon nanohorn hybrid as the carrier.

In Analysis, 2012
A novel gold nanoparticles-single-walled carbon nanohorn (GNPs-SWCNH) hybrid was synthesized for the construction of an amperometric biosensing platform.
Lei Zhang, Jianping Lei, Jing Zhang, Lin Ding, H. Ju   +4 more
semanticscholar   +1 more source

Partial hypoxanthine–guanine phosphoribosyl transferase deficiency without elevated urinary hypoxanthine excretion

Molecular Genetics and Metabolism, 2007
Partial hypoxanthine-guanine phosphoribosyl transferase (HGPRT) deficiency, also known as the Kelley-Seegmiller syndrome, can give rise to a wide range of neurological symptoms, and renal insufficiency. Biochemically, it is characterized by high uric acid concentrations in blood, high uric acid and hypoxanthine excretion in urine, and decreased ...
O. P. van Diggelen, van FrancJan Spronsen, C. M. L. van Dael, Klaziena Niezen-Koning, L. J. W. M. Pierik, Dirk Reijngoud   +5 more
openaire   +4 more sources

Ultrafast nonradiative decay by hypoxanthine and several methylxanthines in aqueous and acetonitrile solution.

Physical Chemistry, Chemical Physics - PCCP, 2012
Excited state lifetimes of hypoxanthine and four methylxanthine compounds (paraxanthine, theophylline, theobromine, and caffeine) were studied by femtosecond transient absorption spectroscopy in aqueous and acetonitrile solution.
Jinquan Chen, B. Kohler
semanticscholar   +1 more source

On the accessibility to conical intersections in purines: hypoxanthine and its singly protonated and deprotonated forms.

Journal of the American Chemical Society, 2012
The dynamics following electronic excitation of hypoxanthine and its nucleoside inosine were studied by femtosecond fluorescence up-conversion. Our objective was to explore variants of the purinic DNA bases in order to determine the molecular parameters ...
Juan P. Villabona-Monsalve, R. Noria, S. Matsika, J. Peón   +3 more
semanticscholar   +1 more source

The Spectrum of Hypoxanthine-guanine Phosphoribosyltransferase Deficiency

QJM: An International Journal of Medicine, 1973
The spectrum of clinical manifestations of hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) deficiency is presented by reference to eight patients from five kindred. These patients illustrate the range of associated neurological findings, together with the variety of presentation and complications due to the associated over-production of urate.
Emmerson, B. T., Thompson, L.
openaire   +3 more sources