Results 311 to 320 of about 93,529 (343)
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Experimental Cell Research, 1977
Abstract We have examined the possible relation between hypoxanthine guanine phosphoribosyltransferase (EC 2.4.2.7., HGPRT) activity and hypoxanthine transport in the normal human lymphoblast line MGL8 and two HGPRT- mutant lines derived from it. The mutant line MGL8A29 (L8A29) had considerable amounts of material cross-reacting immunologically to ...
J. Epstein, J.W. Littlefield
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Abstract We have examined the possible relation between hypoxanthine guanine phosphoribosyltransferase (EC 2.4.2.7., HGPRT) activity and hypoxanthine transport in the normal human lymphoblast line MGL8 and two HGPRT- mutant lines derived from it. The mutant line MGL8A29 (L8A29) had considerable amounts of material cross-reacting immunologically to ...
J. Epstein, J.W. Littlefield
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Chelating ligand conformation driving the hypoxanthine metal binding patterns.
Inorganic Chemistry, 2011The X-ray diffraction structural results of 23 ternary compounds, type M(II)(iminodiacetate-like)(hypoxanthine) [M = Co, Ni, Cu, or Zn], show that the iminodiacetate moiety conformation (mer-NO(2) or fac-NO(2)) is able to drive the M-hypoxanthine binding
D. K. Patel +6 more
semanticscholar +1 more source
Luminescence (Chichester, England Print), 2011
A rapid and simple chemiluminescence method was developed for detection of inosine and hypoxanthine in human plasma. The method utilized a microplate luminometer with direct injectors to automatically dispense reagents during sample analysis.
D. Farthing +10 more
semanticscholar +1 more source
A rapid and simple chemiluminescence method was developed for detection of inosine and hypoxanthine in human plasma. The method utilized a microplate luminometer with direct injectors to automatically dispense reagents during sample analysis.
D. Farthing +10 more
semanticscholar +1 more source
Journal of Organic Chemistry, 2010
A series of 9-mer DNA duplexes of the sequence 5'-d(GGTTXTTGG)-3'/3'-d(CCAAYAACC)-5', where the central base X or Y = adenine (A), guanine (G), thymine (T), cytosine (C), and hypoxanthine (H), have been examined toward understanding the effect of ...
Xuejun Sun, Jeehiun K. Lee
semanticscholar +1 more source
A series of 9-mer DNA duplexes of the sequence 5'-d(GGTTXTTGG)-3'/3'-d(CCAAYAACC)-5', where the central base X or Y = adenine (A), guanine (G), thymine (T), cytosine (C), and hypoxanthine (H), have been examined toward understanding the effect of ...
Xuejun Sun, Jeehiun K. Lee
semanticscholar +1 more source
Journal of Medicinal Chemistry, 2009
The purine salvage enzyme hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) is essential for purine nucleotide and hence nucleic acid synthesis in the malaria parasite, Plasmodium falciparum.
D. Keough +6 more
semanticscholar +1 more source
The purine salvage enzyme hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) is essential for purine nucleotide and hence nucleic acid synthesis in the malaria parasite, Plasmodium falciparum.
D. Keough +6 more
semanticscholar +1 more source
Canadian Journal of Biochemistry, 1969
Isotope exchange between hypoxanthine and both inosinate and guanylate, and between guanine and the same two ribonucleotides, support the view that hypoxanthine and guanine bind to the same site on hypoxanthine-guanine phosphoribosyltransferase.
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Isotope exchange between hypoxanthine and both inosinate and guanylate, and between guanine and the same two ribonucleotides, support the view that hypoxanthine and guanine bind to the same site on hypoxanthine-guanine phosphoribosyltransferase.
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Salvage of circulating hypoxanthine by tissues of the mouse
Canadian Journal of Biochemistry and Cell Biology, 1983Hypoxanthine is an inefficient precursor of purine nucleotides in mouse tissues. In vitro, mouse erythrocytes salvage <10% of hypoxanthine (10 μM) added to whole blood in 30 min of incubation at 37 °C. In vivo, circulating hypoxanthine is rapidly degraded (>90% in 10 min) to allantoin and uric acid. All tissues examined (other than erythrocytes)
J D Moyer, J F Henderson
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Acta Medica Scandinavica, 2009
Release of hypoxanthine and phosphate from exercising legs was studied in eight subjects without known obstructive arterial disease and in 20 claudicants.
D. Sørlie +3 more
semanticscholar +1 more source
Release of hypoxanthine and phosphate from exercising legs was studied in eight subjects without known obstructive arterial disease and in 20 claudicants.
D. Sørlie +3 more
semanticscholar +1 more source
1989
Purine metabolism in the central nervous system (CNS) is characterized by: (i) reduced de novo purine synthesis (1), (ii) increased HPRT activity (2), and (iii) absence of detectable xanthine oxidase activity (3, 4). These facts determine that, instead of uric acid, the end products of purine nucleotide degradation in the CNS are hypoxanthine for ...
Juan G. Puig +5 more
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Purine metabolism in the central nervous system (CNS) is characterized by: (i) reduced de novo purine synthesis (1), (ii) increased HPRT activity (2), and (iii) absence of detectable xanthine oxidase activity (3, 4). These facts determine that, instead of uric acid, the end products of purine nucleotide degradation in the CNS are hypoxanthine for ...
Juan G. Puig +5 more
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Synthesis of hypoxanthin from xanthin
Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 1969We have described a preparative method for producing hypoxanthin by heating xanthin with a mixture of formamide and benzylamine.
S. I. Zav'yalov +4 more
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