Results 171 to 180 of about 34,291 (223)

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT. [PDF]

Science
Wu Z, Nguyen PT, Sondhi V, Yao RW, Lu Z, Dai T, Chiang JC, Cai F, Williams IM, Blatt EB, Shang Z, Cai L, Zhang J, Moore MD, Alshamleh I, Li X, Ogu T, Zacharias LG, Winston R, Patricio JS, Johnson X, Chen WM, Cong Q, Mathews TP, Zhang Y, Zhang L, DeBerardinis RJ.   +26 more
europepmc   +1 more source

Investigation of 6-thioguanine as a strategy to overcome methotrexate resistance in a mouse model of leptomeningeal carcinomatosis. [PDF]

J Neurooncol
Nakagawa H, Yui Y, Suzuki T, Tamura M, Yamada M, Kawaichi M.   +5 more
europepmc   +1 more source

Global Adam17 Deficiency Preserves Renal Function and Modulates Integrated Pathogenic Responses in Experimental Diabetic Kidney Disease. [PDF]

Int J Mol Sci
Riera M, Martyn C, Pujol-Brugués J, Márquez E, Rodríguez E, Palau V, Soler MJ, Gimeno J, Castañeda JSS, Pilco M, Del Risco J, Crespo M, Barrios C.   +12 more
europepmc   +1 more source

Dental Management of Self-Injurious Behavior in Lesch-Nyhan Disease: A Patient- and Caregiver-Reported Outcome Study. [PDF]

Children (Basel)
Capurro C, Parodi S, Buttiglieri S, Romanelli G, Del Buono C, Laffi N.   +5 more
europepmc   +1 more source

Transcriptomic and Metabolomic Analysis Reveals the Impact of Autophagy Regulation on Purine Content in Mutton. [PDF]

Foods
Han X, Chen Y, Tan D, Lai C, Han X, Chen J, Fu Y, Shan X, Jiang H.   +8 more
europepmc   +1 more source

Dedifferentiation and metabolic reprogramming of human adipocytes in the tumor niche triggered by colorectal cancer cells. [PDF]

Biol Res
Pietraszek-Gremplewicz K, Olszańska J, Domagalski M, Tymińska A, Skoniecka A, Pikuła M, Nowak D.   +6 more
europepmc   +1 more source

The Spectrum of Hypoxanthine-guanine Phosphoribosyltransferase Deficiency

QJM: An International Journal of Medicine, 1973
Abstract The spectrum of clinical manifestations of hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) deficiency is presented by reference to eight patients from five kindred. These patients illustrate the range of associated neurological findings, together with the variety of presentation and complications due to the ...
Emmerson, B. T., Thompson, L.
openaire   +5 more sources

Rapid detection of hypoxanthine-guanine phosphoribosyltransferase on cellogel

Humangenetik, 1974
A simple, fast and direct staining method for the detection of hypoxanthineguanine phosphoribosyltransferase is described. It is based on the conversion of inosine monophosphate to hypoxanthine, which is then enzymatically oxidized. This oxidation is coupled to the reduction of a tetrazolium salt to blue formazan.
Someren, H. van, Beijersbergen van Henegouwen, H., Khan, P.M.   +2 more
openaire   +4 more sources

Hypoxanthine-guanine phosphoribosyltransferase: A simple spectrophotometric assay

Clinica Chimica Acta, 1977
A simple spectrophotometric assay is described based on the conversion of hypoxanthine to inosine monophosphate and precipitation of both the reaction product and protein with lanthanum phosphate. The extent of conversion is determined by the fall in absorbance of hypoxanthine at 249 nm.
Johnson L.A., Gordon R.B., Emmerson B.T.
openaire   +5 more sources