Results 1 to 10 of about 3,686 (242)

FLAVIN-HYPOXANTHINE DINUCLEOTIDE

THE JOURNAL OF VITAMINOLOGY, 1957
1. FHD was synthesized from FAD by deamination with nitrous acid and the product was first isolated as barium salt. The yield and purity were, however, unsatisfactory by this method. Therefore, the product was extracted with cresol, followed by transfer in aqueous phase, and by subjecting to column chromatography, FHD was obtained in high purity in ...
Kiyoshi Fujisawa
openaire   +4 more sources

THE ESTIMATION OF HYPOXANTHINE

Journal of Biological Chemistry, 1942
In a previous paper there was described a procedure for the isolation of the purines in a form suitable for the quantitative determination of the individual substances (1). A later publication reported a method for the separation of adenine and hypoxanthine and the determination of the adenine by precipitation of adenine picrate and titration of the ...
George H. Hitchings
openaire   +2 more sources

Human hypoxanthine-guanine phosphoribosyltransferase.

Journal of Biological Chemistry, 1983
A mutant form of human hypoxanthine-guanine phosphoribosyltransferase (HPRTToronto) was isolated from erythrocytes of a male patient with gout due to a partial deficiency of enzyme activity. The tryptic peptides of HPRTToronto were mapped by reverse-phase high pressure liquid chromatography in an attempt to define the precise abnormality in its primary
J M, Wilson, R, Kobayashi, I H, Fox, W N, Kelley   +3 more
openaire   +3 more sources

Hypoxanthine-Guanine Phosphoribosyltransferase [PDF]

, 2020
National Cancer Institute
openaire   +2 more sources

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Recent Trends in Metabolomics by NMR Spectroscopy

Angewandte Chemie, EarlyView.
AI tools were applied to analyze more than 5 000 publications indexed in Scopus (2018–2025), identifying key trends and research directions in NMR‐based metabolomics. The artificial intelligence‐assisted workflow classified papers into six main fields of application, human health, food and nutrition, veterinary science, plants, environment, and ...
Giorgio Di Paco, Gaia Meoni, Veronica Ghini, Alessia Vignoli, Leonardo Tenori, Paola Turano, Claudio Luchinat   +6 more
wiley   +2 more sources

Three Hypoxanthine Derivatives from the Marine Cyanobacterium Okeania hirsuta

Molbank
Three novel hypoxanthine derivatives (1–3) were obtained from the Okinawan cyanobacterium Okeania hirsuta. The structures of these compounds were elucidated mainly based on the spectroscopic data, including 1D and 2D NMR, as well as high-resolution mass ...
Ryoya Kawabe, Botao Zhang, Ryuichi Watanabe, Hajime Uchida, Masayuki Satake, Hiroshi Nagai   +5 more
doaj   +1 more source

Response to Allopurinol and Febuxostat According to the Fractional Excretion of Urate in Men With Gout

Arthritis Care &Research, EarlyView.
Objective Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of uric acid (FEUA) also modulates this response and relates to oxypurinol concentrations.
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche‐Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Perez‐Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang Korng Ea, Thomas Bardin   +13 more
wiley   +1 more source

Rhizosphere metabolite-mediated soil enhancement: long-term biochar application optimizes continuous soybean production systems

Biochar
Biochar offers promising solutions for agricultural sustainability, yet the intricate mechanisms governing rhizosphere metabolite-microbe-soil interactions remain poorly understood. Through a decade-long field experiment, the effects of sustained biochar
Di Wu, Yuxue Zhang, Wenqi Gu, Zifan Liu, Wenjia Wang, Yuanyuan Sun, Liqun Xiu, Weiming Zhang, Wenfu Chen   +8 more
doaj   +1 more source

A New 3D Colon on a Chip to Decipher the Influence of Mechanical Forces on the Physiological Cellular Ecosystem

Advanced Healthcare Materials, EarlyView.
To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon‐on‐chip that integrates tunable topography, stiffness and peristalsis‐like motion within a physiologically relevant microenvironment. We showed that stretching is a dominant factor governing epithelial behavior, markedly enhancing proliferation and ...
Moencopi Bernheim‐Dennery, Lauriane Gérémie, Julie Brun, Lucas Chassatte, Giacomo Gropplero, Réda Bouras, Jieun Choo, Bertrand Cinquin, Alba Marcellan, Danijela Matic Vignjevic, Stéphanie Descroix   +10 more
wiley   +1 more source