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Human and Mouse Hypoxanthine-Guanine Phosphoribosyltransferase: Dimers and Tetramers
Science, 1979Human and mouse hypoxanthine-guanine phosphoribosyltransferase subunits combine to form an active heteropolymer. Dimers form the basic subunit structure of the enzymes, yet the dimers can readily associate to form tetramers. The equilibrium between dimers and tetramers is significantly influenced by the ionic strength of the enzyme solvent.
Gerald G. Johnson+2 more
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Role of Human Hypoxanthine Guanine Phosphoribosyltransferase in Nucleotide Interconversion
1980It is well established that human Hypoxanthine-Guanine Phospho-ribosyltransferase (HGPRT, EC 2.4.2.8) catalyzes the reactions: Open image in new window Open image in new ...
GIACOMELLO, Alessandro+1 more
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Canadian Journal of Biochemistry, 1969
Isotope exchange between hypoxanthine and both inosinate and guanylate, and between guanine and the same two ribonucleotides, support the view that hypoxanthine and guanine bind to the same site on hypoxanthine-guanine phosphoribosyltransferase.
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Isotope exchange between hypoxanthine and both inosinate and guanylate, and between guanine and the same two ribonucleotides, support the view that hypoxanthine and guanine bind to the same site on hypoxanthine-guanine phosphoribosyltransferase.
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Biochemical and Biophysical Research Communications, 1967
J. Frank Henderson+3 more
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J. Frank Henderson+3 more
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Genetic heterogeneity at the locus for hypoxanthine-guanine phosphoribosyltransferase.
Ciba Foundation symposium, 1977The purine phosphoribosyltransferases have emerged as important enzymes in the metabolic economy of the developing human. Hypoxanthine-guanine phosphoribosyltransferase (HGPRT, EC 2.4.2.8) catalyses the conversion of hypoxanthine and guinine into their respective nucleotides.
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Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
RCSB Protein Data Bank, 2012openaire +2 more sources
Erythrocyte nucleotide variations in hypoxanthine phosphoribosyltransferase deficiency
Journal of Inherited Metabolic Disease, 1991G. M. McCreanor, R. A. Harkness
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