Results 231 to 240 of about 33,169 (270)
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Purification of hypoxanthine-guanine phosphoribosyltransferase of Plasmodium lophurae
Molecular and Biochemical Parasitology, 1987Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) was isolated from the malarial parasite, Plasmodium lophurae. The apparent pI, as determined by chromatofocusing, was 7.6. The native molecular weight was 79,000. The pH profile of HGPRT exhibited a broad pH optimum. With hypoxanthine as substrate maximal activity was achieved from pH 6.0-10.0,
C M, Schimandle, L A, Mole, I W, Sherman
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Rapid detection of hypoxanthine-guanine phosphoribosyltransferase on cellogel
Humangenetik, 1974A simple, fast and direct staining method for the detection of hypoxanthineguanine phosphoribosyltransferase is described. It is based on the conversion of inosine monophosphate to hypoxanthine, which is then enzymatically oxidized. This oxidation is coupled to the reduction of a tetrazolium salt to blue formazan.
Someren, H. van +2 more
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1974
Partial deficiency of HGPRT, a salvage enzyme of purine metabolism, has been demonstrated to be the primary abnormality causing purine overproduction in a small proportion of patients with gout (1–4). The quantitative deviation in the activity of this enzyme has been shown by Kelley et al.
O, Sperling, P, Boer, A, De Vries
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Partial deficiency of HGPRT, a salvage enzyme of purine metabolism, has been demonstrated to be the primary abnormality causing purine overproduction in a small proportion of patients with gout (1–4). The quantitative deviation in the activity of this enzyme has been shown by Kelley et al.
O, Sperling, P, Boer, A, De Vries
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Evidence for tetrameric structure of mammalian hypoxanthine phosphoribosyltransferase
Biochemical Genetics, 1987A fast electrophoretic variant of hypoxanthine phosphoribosyltransferase (HPRT) has been detected in Mus musculus bactrianus, a mouse subspecies from Middle Asia (USSR). The electrophoretic HPRT pattern yielded by hybrids between the somatic cell of LMTK- (deficient in thymidine kinase) and the splenocytes of a male of M. m. bactrianus was five-banded.
M N, Bochkarev +5 more
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[Deficiencies of hypoxanthine guanine phosphoribosyltransferase (HPRT)].
Nihon rinsho. Japanese journal of clinical medicine, 2008Inherited mutations of a purine salvage enzyme, hypoxanthine guanine phosphoribosyltransferase (HPRT, EC 2.4.2.8; MIM308000), give rise to Lesch-Nyhan syndrome (MIM300322) or HPRT-related gout called as Kelley-Seegmiller syndrome (MIM300323). In contrast with the most severe phenotype of classical Lesch-Nyhan disease (LND), the least severe phenotype ...
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Human Hypoxanthine-Guanine Phosphoribosyltransferase (HGPRT): Purification and Properties
1974Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (E.C. 2.4.2.8.) catalyzes the formation of guanosine-5’-monophosphate and inosine-5’-monophosphate from 5’-phosphoribosyl-l-pyrophosphate (PPribose-P) and the purine bases guanine and hypoxanthine, respectively.
W J, Arnold, R V, Lamb, W N, Kelley
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Genetic and Clinical Heterogeneity in Hypoxanthine Phosphoribosyltransferase Deficiencies
1995Complete deficiency of HPRT causes the Lesch-Nyhan syndrome (LNS) which is characterized by hyperuricemia, mental retardation, choreoathetosis, and compulsive self-mutilation. Partial deficiency of HPRT leads to a severe form of gout and nephrolithiasis. In contrast to the Lesch-Nyhan syndrome it has been proposed to designate this as Kelley-Seegmiller
R, Burgemeister +3 more
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Biochemical and Biophysical Research Communications, 1967
W N, Kelley +3 more
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W N, Kelley +3 more
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Erythrocyte nucleotide variations in hypoxanthine phosphoribosyltransferase deficiency
Journal of Inherited Metabolic Disease, 1991R A, Harkness, G M, McCreanor
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