Results 1 to 10 of about 579 (178)

Metabolomics in Team-Sport Athletes: Current Knowledge, Challenges, and Future Perspectives. [PDF]

Proteomes, 2022
Metabolomics is a promising tool for studying exercise physiology and exercise-associated metabolism. It has recently been defined with the term "sportomics" due to metabolomics' capability to characterize several metabolites in several biological ...
Bongiovanni T, Lacome M, Fanos V, Martera G, Cione E, Cannataro R.   +5 more
europepmc   +3 more sources

Microbiome-derived metabolites in early to mid-pregnancy and risk of gestational diabetes: a metabolome-wide association study. [PDF]

BMC Med
BACKGROUND: Pre-diagnostic disturbances in the microbiome-derived metabolome have been associated with an increased risk of diabetes in non-pregnant populations.
Susarla SM, Fiehn O, Thiele I, Ngo AL, Barupal DK, Chehab RF, Ferrara A, Zhu Y.   +7 more
europepmc   +3 more sources

Preliminary study on the potential impact of probiotic combination therapy on Helicobacter pylori infection in children using 16S gene sequencing and untargeted metabolomics approach. [PDF]

Front Microbiol
ObjectiveThe purpose of this study was to explore the potential mechanism of Helicobacter pylori (Hp) eradication by probiotic therapy through 16S rRNA gene sequencing technology and untargeted metabolomics.MethodsTwenty four Hp-infected children were ...
Yan Y, Dong L, Xu J, Zhang Z, Jia P, Zhang J, Chen W, Gao W.   +7 more
europepmc   +3 more sources

Beneficial Effects of Ketogenic Diet on Phosphofructokinase Deficiency (Glycogen Storage Disease Type VII). [PDF]

Front Neurol, 2020
Background: A deficiency of muscle phosphofructokinase (PFKM) causes a rare metabolic muscle disease, the Tarui disease (Glycogen storage disease type VII, GSD VII) characterized by exercise intolerance with myalgia due to an inability to use glucose as ...
Similä ME, Auranen M, Piirilä PL.
europepmc   +3 more sources

The role of veracity on the load monitoring of professional soccer players: a systematic review in the face of the big data era [PDF]

, 2021
Big Data has real value when the veracity of the collected data has been previously identified. However, data veracity for load monitoring in professional soccer players has not been analyzed yet.
Afonso, José, Araujo, André Luiz Costa, Boullosa, Daniel, Cardoso Filho, Carlos Alberto, Carrion, Gustavo Rejano, Claudino, João Gustavo, Del Rosso, Sebastián, Gianoni, Rodrigo Luiz da Silva, Guimarães, Rodrigo Dos Santos, Lima-Alves, Adriano, Serrão, Julio Cerca, Ventura, Fúlvio Martins   +11 more
core   +2 more sources

Assessment of free radical scavenging and digestive enzyme inhibitory activities of extract, fractions and isolated compounds from Tetracera macrophylla leaves [PDF]

, 2020
Tetracera macrophylla is a valuable medicinal plant used traditionally for the treatment of various ailments. The crude ethanol extract was analyzed for its total phenolic and flavonoid contents.
Ahmed, Qamar Uddin, Alhassan, Alhassan Muhammad, Ali Shah, Syed Adnan, Latip, Jalifah, Mat So'ad, Siti Zaiton, Opeyemi Roheem, Fatimah, Syed Mohammad, Sharifah Nurul Akilah   +6 more
core   +1 more source

Hypoxanthine uptake by human erythrocytes [PDF]

FEBS Letters, 1979
It is well established that the uptake of hypoxan- thin, by human erythrocytes is mediated by its incorporation into IMP [ 11. The synthesis of this nucleotide is dependent on the intracellular availability of 5phosphoribosyl o-1-pyrophosphate (PRPP) and on the activity of hypoxanthine-guanine phospho- ribosyltransferase (HGPRT) [ 11.
GIACOMELLO, Alessandro, SALERNO, Costantino   +1 more
openaire   +4 more sources

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Simultaneous quantification of 12 different nucleotides and nucleosides released from renal epithelium and in human urine samples using ion-pair reversed-phase HPLC [PDF]

, 2012
Nucleotides and nucleosides are not only involved in cellular metabolism but also act extracellularly via P1 and P2 receptors, to elicit a wide variety of physiological and pathophysiological responses through paracrine and autocrine signalling pathways.
Alberto Contreras-Sanz, BD Gill, C Crawford, Claire M. Peppiatt-Wildman, DR Ferguson, DR Schneider, EM Schwiebert, EW Inscho, EW Inscho, FQ Yang, G Burnstock, G Burnstock, G Burnstock, G Manfredi, G Xu, HA Neufeld, HA Praetorius, HA Praetorius, Hardyal S. Gill, HM Liebich, I Kugelgen von, I Kugelgen von, J Czarnecka, James Malone-Lee, JC Mathies, Jennifer C. Jacoby, JM Buescher, JO Svensson, JR Gever, K Sugaya, Kevin M. G. Taylor, KH Schram, KR Kim, LA Birder, LC Rump, LD Todorov, M Cichna, M Katayama, MA Bailey, N Ozer, N Yamaoka, NS Zur, P Bodin, P Vinas, PD Wilson, R Corriden, RC Calvert, Rebecca E. Birch, RL Cordell, S Tatur, S Wiener, SA Levesque, Scott S. P. Wildman, Toby S. Scott-Ward, V Jankowski, V Kumar, W Yu, Y Cheng, Y Sun, Y Sun, Y Zheng   +60 more
core   +2 more sources

Study on the efficacy of compound porcine cerebroside and ganglioside injection in patients with ischemic stroke: A randomized, single‐center, open‐label, prospective study

Ibrain, EarlyView., 2023
Compound porcine perebroside and ganglioside injection (CPCGI) was used to treat ischemic stroke. However, there was no clinical evidence of low‐dose CPCGI. We conducted a clinical study to analyze whether the clinical results of low‐dose and standard‐dose CPCGI in patients with ischemic stroke were different.
Ya Chen, Xia Zhang, Hai‐Qing Zhang, Zhong Luo, Xue‐Jiao Zhou, Tao Liang, Fei Yang, Jun Zhang, Zu‐Cai Xu   +8 more
wiley   +1 more source