Results 161 to 170 of about 579 (178)
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Uptake of Hypoxanthine in Human Erythrocytes
1977The concentration of oxypurines in the plasma is known to be rather low (10 – 40 μM) (6). Since the formation of purines is accomplished to a great extent by the liver (7, 8), a transport of purines by erythrocytes from liver to tissues with limited or no capacity of de novo purine synthesis has been postulated (1, 3).
G. Falkner, Mathias Müller
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Molecular Genetics and Metabolism, 2007
Partial hypoxanthine-guanine phosphoribosyl transferase (HGPRT) deficiency, also known as the Kelley-Seegmiller syndrome, can give rise to a wide range of neurological symptoms, and renal insufficiency. Biochemically, it is characterized by high uric acid concentrations in blood, high uric acid and hypoxanthine excretion in urine, and decreased ...
O. P. van Diggelen +5 more
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Partial hypoxanthine-guanine phosphoribosyl transferase (HGPRT) deficiency, also known as the Kelley-Seegmiller syndrome, can give rise to a wide range of neurological symptoms, and renal insufficiency. Biochemically, it is characterized by high uric acid concentrations in blood, high uric acid and hypoxanthine excretion in urine, and decreased ...
O. P. van Diggelen +5 more
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The Spectrum of Hypoxanthine-guanine Phosphoribosyltransferase Deficiency
QJM: An International Journal of Medicine, 1973The spectrum of clinical manifestations of hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) deficiency is presented by reference to eight patients from five kindred. These patients illustrate the range of associated neurological findings, together with the variety of presentation and complications due to the associated over-production of urate.
Emmerson, B. T., Thompson, L.
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Experimental Cell Research, 1977
Abstract We have examined the possible relation between hypoxanthine guanine phosphoribosyltransferase (EC 2.4.2.7., HGPRT) activity and hypoxanthine transport in the normal human lymphoblast line MGL8 and two HGPRT- mutant lines derived from it. The mutant line MGL8A29 (L8A29) had considerable amounts of material cross-reacting immunologically to ...
J. Epstein, J.W. Littlefield
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Abstract We have examined the possible relation between hypoxanthine guanine phosphoribosyltransferase (EC 2.4.2.7., HGPRT) activity and hypoxanthine transport in the normal human lymphoblast line MGL8 and two HGPRT- mutant lines derived from it. The mutant line MGL8A29 (L8A29) had considerable amounts of material cross-reacting immunologically to ...
J. Epstein, J.W. Littlefield
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Salvage of circulating hypoxanthine by tissues of the mouse
Canadian Journal of Biochemistry and Cell Biology, 1983Hypoxanthine is an inefficient precursor of purine nucleotides in mouse tissues. In vitro, mouse erythrocytes salvage <10% of hypoxanthine (10 μM) added to whole blood in 30 min of incubation at 37 °C. In vivo, circulating hypoxanthine is rapidly degraded (>90% in 10 min) to allantoin and uric acid. All tissues examined (other than erythrocytes)
J D Moyer, J F Henderson
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Mouse models of hypoxanthine phosphoribosyltransferase deficiency
Journal of Inherited Metabolic Disease, 1992SummaryLesch‐Nyhan syndrome is an X‐linked disease caused by the deficiency of hypoxanthine phosphoribosyltransferase, an enzyme involved in the purine salvage pathways. It is characterized by severe gout, choreoathetosis, self‐mutilatory behaviour and mental retardation. The derivation of mice genetically deficient in this enzyme may help to elucidate
M. L. Hooper +2 more
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Canadian Journal of Biochemistry, 1969
Isotope exchange between hypoxanthine and both inosinate and guanylate, and between guanine and the same two ribonucleotides, support the view that hypoxanthine and guanine bind to the same site on hypoxanthine-guanine phosphoribosyltransferase.
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Isotope exchange between hypoxanthine and both inosinate and guanylate, and between guanine and the same two ribonucleotides, support the view that hypoxanthine and guanine bind to the same site on hypoxanthine-guanine phosphoribosyltransferase.
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Synthesis of hypoxanthin from xanthin
Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 1969We have described a preparative method for producing hypoxanthin by heating xanthin with a mixture of formamide and benzylamine.
S. I. Zav'yalov +4 more
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1989
Purine metabolism in the central nervous system (CNS) is characterized by: (i) reduced de novo purine synthesis (1), (ii) increased HPRT activity (2), and (iii) absence of detectable xanthine oxidase activity (3, 4). These facts determine that, instead of uric acid, the end products of purine nucleotide degradation in the CNS are hypoxanthine for ...
Juan G. Puig +5 more
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Purine metabolism in the central nervous system (CNS) is characterized by: (i) reduced de novo purine synthesis (1), (ii) increased HPRT activity (2), and (iii) absence of detectable xanthine oxidase activity (3, 4). These facts determine that, instead of uric acid, the end products of purine nucleotide degradation in the CNS are hypoxanthine for ...
Juan G. Puig +5 more
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Hypoxanthine Uptake by Isolated Brain Microvessels
1986Brain is among the most active tissues in nucleotide and nucleic acid synthesis (1) but the role of the blood brain barrier in regulating the transport of purine and pyrimidine has not, so far, well defined. The existence of a presynaptic purinergic modulation of trasmitter release in the central nervous system (1) emphasize a possibly important role ...
P. Cardelli Cangiano +4 more
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