Results 51 to 60 of about 3,545 (197)

Anti-inflammatory potential of Penicillium brefeldianum endophytic fungus supported with phytochemical profiling. [PDF]

open access: yesMicrob Cell Fact, 2023
Saleh A   +9 more
europepmc   +1 more source

Narrative review of strategies for blood product shelf‐life extension

open access: yes
Transfusion, EarlyView.
Mike Akaraphanth   +7 more
wiley   +1 more source

ITM2B Truncation Promotes Migrasome Formation to Accelerate Renal Cell Carcinoma Growth

open access: yesAdvanced Science, Volume 13, Issue 4, 19 January 2026.
This study identifies truncated ITM2B as a regulator of migrasome formation in renal cell carcinoma (RCC) cells. The ITM2B truncation not only facilitates migrasome formation by recruiting TSPAN4, but also sorts active caspase‐7 into migrasomes. The internalization of active caspase‐7‐enriched migrasomes by macrophages stimulates IL‐6 secretion to ...
Qi‐tao Chen   +10 more
wiley   +1 more source

A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists. [PDF]

open access: yesACS Med Chem Lett, 2021
Villemure E   +9 more
europepmc   +1 more source

Serendipitous Symptom Control: Allopurinol for Spasticity in a Case of SPG4‐Linked Hereditary Spastic Paraplegia—A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 1, January 2026.
Graphical representation of spasticity and medication changes. (A) Temporal course of lower limb spasticity measured by MAS scores. Following initiation of allopurinol 300 mg daily at baseline (red dashed line), there was a rapid and sustained improvement in spasticity from severe (MAS = 4) to mild (MAS = 1.8) over 12 months of follow‐up, represented ...
Ziad W. Elmezayen   +3 more
wiley   +1 more source

Baseline multi‐omics signatures could predict therapeutic response to neoadjuvant anti‐PD‐1 immunochemotherapy in non‐small‐cell lung cancer

open access: yesClinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Overview of study design. Metagenomic and plasma/fecal metabolomic studies were performed in 44 NSCLC patients who underwent neoadjuvant tislelizumab therapy plus platinum ‐ based doublet chemotherapy. Abstract Background Neoadjuvant anti‐programmed cell death 1 (PD‐1) immunochemotherapy has shown promising efficiency in the treatment of early‐stage ...
Ailing Cao   +11 more
wiley   +1 more source

Profiles and integration of the gut microbiome and fecal metabolites in severe intrahepatic cholestasis of pregnancy. [PDF]

open access: yesBMC Microbiol, 2023
Li X   +8 more
europepmc   +1 more source

Serum Uric Acid as a Mediator of Insulin Resistance: Molecular Mechanisms and Metabolic Pathways

open access: yesEndocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Elevated SUA can lead to oxidative stress, endothelial dysfunction, inflammation and impaired function of adipocytes—all of which collectively impede insulin receptor activity and downstream signalling. Key pathways involved include activation of the NLRP3 inflammasome, suppression of AMPK and induction of mitochondrial dysfunction.
Nurshad Ali
wiley   +1 more source

Metabolic Signature of Energy Metabolism Alterations and Excess Nitric Oxide Production in Culture Media Correlate with Low Human Embryo Quality and Unsuccessful Pregnancy. [PDF]

open access: yesInt J Mol Sci, 2023
Pallisco R   +13 more
europepmc   +1 more source

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