Results 331 to 340 of about 1,301,346 (361)
Re: Levels of Hypoxia-Inducible Factor-1 During Breast Carcinogenesis
A. Costa+5 more
openalex +1 more source
Hydrogen‐Producing Catalysts Based on Ferredoxin Scaffolds
Selected plant‐type ferredoxins that lack their natural [2Fe‐2S] clusters functionally bind a hydrogenase active site cofactor and act as hydrogenases themselves. In combination with photosystem I, the light‐dependent H₂ evolution almost matches the H₂ production rates of the natural system.
Yiting She+6 more
wiley +1 more source
Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy
This article introduces a novel therapeutic paradigm that deliberately induces reductive stress within tumor cells to exploit their unique biochemical vulnerabilities. It systematically reviews the underlying biological mechanisms, current detection and monitoring techniques, and emerging advanced nanotechnology platforms specifically designed to ...
Yumin Mao+8 more
wiley +1 more source
RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang+7 more
wiley +1 more source
Histone Demethylase UTX Suppresses Tumor Cell Proliferation by Regulating Stress Granules
These findings indicate that cytoplasmic UTX forms puncta and co‐localizes in stress granules (SGs) upon various stresses. UTX TPR‐domain‐dependently and demethylase‐activity‐independently destabilize SGs by binding G3BP1, the SG hub protein, to disrupt SG network, thus affects tumorigenesis.
Xikai Liu+17 more
wiley +1 more source
Gut metabolite trimethylamine N‐oxide accumulates in the diabetic wound area to amplify macrophage inflammation via enhancing glycolysis activities. Kinsenoside induces macrophage repolarization from M1 to M2 phenotype through inhibiting IRE1α/XBP1 pathway, followed by HIF‐1α‐glycolysis axis repression and mitophagy‐oxidative phosphorylation axis ...
Li Lu+13 more
wiley +1 more source
Inspired by the structural and functional characteristics of bone, bionic nanomaterials combined with nanotechnology can more accurately replicate stem cell niches, enabling the design of bone tissue engineering scaffolds with diverse nanoscale properties to promote stem cell migration, proliferation, and differentiation. This precise control over stem
Yangfan Pei+11 more
wiley +1 more source
The AuCu@CuO2 aerogels demonstrate favorable photothermal properties, four types of enzyme‐like activities, and H2O2/O2 self‐supplying to modulate the complex microenvironment of MRSA‐infected diabetic wounds. The results indicate that the AuCu@CuO2 aerogel can be activated by the microenvironment of diabetic wound infection, alleviating inflammation ...
Xiaofeng Tan+10 more
wiley +1 more source
Mesoporous gold nanospheres confined platinum nanoclusters (MGNSs@Pt) is developed as robust hydroxyl radical and oxygen nanogenerators for multimodal therapies. Their NIR‐II LSPR property also allowed MGSNs to be ideal phototheranostic agents. The chemodynamic and photothermal therapy efficiently induced the tumor cell apoptosis, enabling the MGNSs@Pt
Fei Cun+7 more
wiley +1 more source
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma+9 more
wiley +1 more source