Results 141 to 150 of about 592,371 (315)

Tale of two transcription factors: NF-кB and HIF crosstalk [PDF]

, 2013
Hypoxia-inducible factor is a key transcriptional factor involved in the cellular response to low levels of oxygen, hypoxia. Moreover, hypoxia-inducible factor has been recently associated with a role in inflammation and immunity.
Rocha, S., Bandarra, D.
core  

Cyclic Olefin Copolymers as Versatile Materials for Advanced Engineering Applications

Advanced Functional Materials, EarlyView.
Cyclic olefin copolymers (COCs) are presented as highly versatile materials combining tunable synthesis, excellent optical properties, and mechanical robustness. Their potential spans microfluidics, bioengineering, and advanced electronics, while emerging self‐healing and sustainable solutions highlight future opportunities.
Giulia Fredi, Norma Mallegni, Andrea Dorigato, Mario Milazzo   +3 more
wiley   +1 more source

Higher hemoglobin levels are associated with adverse heart rate variability in a middle‐aged birth cohort

Physiological Reports
High hemoglobin (Hb) levels within normal variation range are considered beneficial. However, lower Hb levels within normal variation range are associated with healthier cardiovascular traits. Heart rate variability (HRV) and baroreflex sensitivity (BRS)
Samuli Sakko, Mikko. P. Tulppo, Peppi Koivunen, Joona Tapio   +3 more
doaj   +1 more source

Hypoxia and ferroptosis

Cellular Signalling
Ferroptosis is a novel, iron-dependent cell death characterized by the excessive accumulation of ferroptosis lipid peroxides ultimately leading to oxidative damage to the cell membrane. Iron, lipid, amino acid metabolism, and other signaling pathways all control ferroptosis.
Xiao-Qian, Liu, Meng-Zhen, Shi, Yu-Ting, Bai, Xiao-Ling, Su, Yan-Min, Liu, Jin-Chun, Wu, Li-Rong, Chen   +6 more
openaire   +2 more sources

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Analysis of Hypoxia-Steroidogenesis Interplay in Zebrafish

reservedHypoxia is a condition of insufficient oxygen to maintain adequate tissue homeostasis. Depending on its severity, hypoxic conditions in the body can lead to cell damage or metabolic imbalances, as well as contribute to chronic diseases like COPD,
BHARDVAJ, PARISHA
core  

Hypoxia-Activated Pro-Drugs of the KDAC Inhibitor Vorinostat (SAHA)

, 2019
Hypoxia (lower than normal oxygen) is a characteristic of most solid tumours that results in poor cancer patient prognosis. The difference in cellular environment between normoxia (21% oxygen) or physoxia (4.5-7% oxygen) and hypoxia (
Anna Skwarska (7483759), Ester M. Hammond (7483769), Ishna N. Mistry (7483765), Stuart Conway (5491424), Ewen D. D. Calder (7483764), Deborah Sneddon (7483767)   +5 more
core   +1 more source

Epidermal Patch Technologies for Integrated Healthcare and Infection Management

Advanced Healthcare Materials, EarlyView.
Epidermal patches have evolved from simple wound coverings into multifunctional, skin‐conformable platforms integrating drug delivery, biosensing, and therapeutic functionalities. This review highlights their material innovations, fabrication strategies, and intelligent designs, including hydrogels, microneedles, and flexible electronics, while ...
Yuqi Wang, Atakan Tevlek, Pawel L. Urban, Boaz Mizrahi, Onome Ejeromedoghene, Roshan Deen, Yuanjing Lin, Jagan Mohan Dodda   +7 more
wiley   +1 more source

Bubble Formation Control: Fabrication of Centimeter‐Sized Tissue‐Like Constructs by Catalase‐Coated Oxygen‐Releasing Hydrogel

Advanced Materials, EarlyView.
Oxygen‐releasing hydrogels are widely used to support cell survival in 3D cultures and to promote wound healing. However, incorporating catalase to convert H2O2 into O2 often generates additional oxygen bubbles, leading to material instability which rarely addressed.
Sukulya Bunuasunthon, Isabel F. Amaral, Ana P. Pêgo, Michiya Matsusaki   +3 more
wiley   +1 more source

A yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machinery

, 2008
Background: Several human pathologies, including neoplasia and ischemic cardiovascular diseases, course with an unbalance between oxygen supply and demand ( hypoxia).
Alcaide-German, ML, Del Peso, L, Garcia-Fernandez, LF, Vara-Vega, A, Landazuri, MO   +4 more
core