Results 321 to 330 of about 1,114,410 (399)

Effects of hypoxia-reoxygenation on the bioenergetics and oxidative stress in the isolated mitochondria of the king scallop, Pecten maximus.

J Exp Biol
Lumor L, Bock C, Mark FC, Ponsuksili S, Sokolova I.   +4 more
europepmc   +1 more source

Attenuated PINK1 autophosphorylation play neuroprotective and anti-seizure roles in neonatal hypoxia. [PDF]

Sci Rep
Yuan Y, Wang X, Cui Y, Zhou H, Li W, Teng Q, Wang H, Sun B, Wang Q, Sun H, Tang J.   +10 more
europepmc   +1 more source

FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity

Advanced Science, EarlyView.
Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li, Huihui Yu, Ruixian Tian, Xingxing Wang, Ting Xing, Chenyi Xu, Tengteng Li, Xue Du, Qianqian Cui, Biao Yu, Yunxia Cao, Zongzhi Yin   +11 more
wiley   +1 more source

Polarized macrophages modulate cardiac structure and contractility under hypoxia in novel immuno-heart on a chip. [PDF]

APL Bioeng
Schmidt AA, David LM, Qayyum NT, Tran K, Van C, Hetta AHSHA, Shrestha RL, Varatip AO, Butenko S, Enriquez-Ochoa D, Nguyen C, Seldin MM, Liu WF, Grosberg A.   +13 more
europepmc   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Carbonic anhydrase IX downregulation linked to disruption of HIF-1, NFκB and STAT3 pathways as a new mechanism of ibuprofen anti-cancer effect. [PDF]

PLoS One
Grossmannova K, Belvoncikova P, Puzderova B, Simko V, Csaderova L, Pastorek J, Barathova M.   +6 more
europepmc   +1 more source

Responsive ROS‐Augmented Prodrug Hybridization Nanoassemblies for Multidimensionally Synergitic Treatment of Hepatocellular Carcinoma in Cascade Assaults

Advanced Science, EarlyView.
This study proposes a novel HCC therapy using CA‐4S2@ES‐Cu nanomedicines to amplify cuproptosis, enhancing chemotherapy and immunotherapy. CA‐4 and ES‐Cu synergistically inhibit tumor growth, induce immune responses, and reverse the immunosuppressive microenvironment, offering an effective multidimensional therapeutic strategy for HCC treatment ...
Yingjie Zeng, Yuening Cao, Senmiao Ren, Chaozheng Zhang, Jianan Liu, Ke Liu, Yan Wang, Hongyu Chen, Fengjiao Zhou, Xiuli Yang, Xian Ge, Tingting Zhang, Tianbao Wang, Yao He, Defang Li, Chuantao Zhang, Jun Lu   +16 more
wiley   +1 more source

The glucose metabolism reprogramming of yak Sertoli cells under hypoxia is regulated by autophagy. [PDF]

BMC Genomics
Ma R, Cui Y, Yu SJ, Pan YY, He JF, Wang YY, Wang JL, Wang XY, Bai XF, Zhang H, Yang SS, Zhang Q.   +11 more
europepmc   +1 more source

A Dual‐Modal Wearable Pulse Detection System Integrated with Deep Learning for High‐Accuracy and Low‐Power Sleep Apnea Monitoring

Advanced Science, EarlyView.
A dual‐modal wearable pulse detection system is developed for sleep apnea monitoring by integrating a self‐powered PENG and PPG sensor with a biomimetic fingertip structure. Through a two‐stage detection strategy, continuous PPW monitoring and on‐demand PPG detection achieve high‐accuracy sleep apnea recognition while maintaining low power consumption.
Jia Wang, Jiangtao Xue, Yang Zou, Yuxin Ma, Junhan Xu, Yanming Li, Fei Deng, Yiqian Wang, Kai Xing, Zhou Li, Tong Zou   +10 more
wiley   +1 more source

Study on the Protective Effect of Methyl Rosmarinate on Hypoxic Mice and Their Erythrocytes. [PDF]

Drug Des Devel Ther
Guo Q, Yin Z, Wang R, Sun Y, Zhao A, Yao W, Li W.   +6 more
europepmc   +1 more source