Results 331 to 340 of about 1,114,410 (399)

Bispecific Antibody Targeting VEGF/TGF‐β Synergizes with Local Radiotherapy: Turning Tumors from Cold to Inflamed and Amplifying Abscopal Effects

Advanced Science, EarlyView.
Y332D, a bispecific antibody that simultaneously blockades VEGF and TGF‐β, counteracted negative RT effects that are attributed to the upregulation of TGF‐β and VEGF, as well as further enhanced the immunostimulatory effects of RT, thereby reprograming the TME from immune “cold” to inflamed state and forming an effective in‐situ vaccine that eradicate ...
Lijuan Lyu, Ming Yi, Ji Chen, Jing Zhang, Xiaobin Ma, Xiaojun Zhang, Liang Zeng, Yan Xue, Haimei Wen, Yujiao Deng, Pengfei Zhou, Kongming Wu, Huafeng Kang, Zhijun Dai   +13 more
wiley   +1 more source

Kinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis

Advanced Science, EarlyView.
Gut metabolite trimethylamine N‐oxide accumulates in the diabetic wound area to amplify macrophage inflammation via enhancing glycolysis activities. Kinsenoside induces macrophage repolarization from M1 to M2 phenotype through inhibiting IRE1α/XBP1 pathway, followed by HIF‐1α‐glycolysis axis repression and mitophagy‐oxidative phosphorylation axis ...
Li Lu, Jiewen Liao, Chao Xu, Yuan Xiong, Juan Zhou, Guangji Wang, Ze Lin, Kangkang Zha, Chuanlu Lin, Ruiyin Zeng, Guandong Dai, Qian Feng, Bobin Mi, Guohui Liu   +13 more
wiley   +1 more source

High-altitude retinopathy - a potential model for retinal haemorrhages in suspected shaken baby syndrome. [PDF]

Eye (Lond)
Lynøe N, Eriksson A.
europepmc   +1 more source

Prediction of Microvascular Adaptation to Hypoxia Based on Myogenic Microcirculation Oscillations. [PDF]

Sensors (Basel)
Marcinek A, Katarzynska J, Stanek A, Gebicki J.   +3 more
europepmc   +1 more source

Arginase 1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction. [PDF]

Signal Transduct Target Ther
She H, Zheng J, Zhao G, Du Y, Tan L, Chen ZS, Wu Y, Li Y, Liu Y, Sun Y, Hu Y, Zuo D, Mao Q, Liu L, Li T.   +14 more
europepmc   +1 more source

Intermittent hypoxia index: a new indicator for assessing the degree of intermittent hypoxia in obstructive sleep apnea. [PDF]

Front Med (Lausanne)
Xie K, Tang X, Zhou J, Liu X, Zhang Y, Cui X.   +5 more
europepmc   +1 more source

Hypoxia-Dependent Upregulation of VEGF Relies on β3-Adrenoceptor Signaling in Human Retinal Endothelial and Müller Cells. [PDF]

Int J Mol Sci
Lucchesi M, Di Marsico L, Guidotti L, Lulli M, Filippi L, Marracci S, Dal Monte M.   +6 more
europepmc   +1 more source

Time-course of muscle fatigue development during intense exercise in hypoxia and normoxia. [PDF]

Sci Rep
Bejder J, Graae J, Andersen JB, Barbieri RA, Campos EZ, Bangsbo J, Nybo L, Nordsborg NB.   +7 more
europepmc   +1 more source