Results 81 to 90 of about 939,686 (311)

Exploration of various roles of hypoxia genes in osteosarcoma [PDF]

, 2022
Jimin Ma, Ziming Guo, Xuefei Yang, Zhu Ya-kun   +3 more
openalex   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster [PDF]

, 2014
Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival.
An, Azad, Bartels, Bonello, Centanin, Culver, Cummins, Cummins, Daniel Bandarra, Dekanty, Fandrey, Fu, Glittenberg, H. Arno Muller, Harhaj, Hetru, Jiang, John Biddlestone, Jono, Kenneth, Kounatidis, Lando, Lavista-Llanos, Liu, Lu, Massoumi, Melvin, Moniz, Perkins, Perkins, Ratcliffe, Rius, Rocha, Romero, Ruland, Scholz, Semenza, Sharon Mudie, Silke, Silverman, Silverman, Sonia Rocha, Sonnenfeld, Tornatore, Tsichritzis, van Uden, van Uden, Walmsley, Xue   +48 more
core   +5 more sources

Characteristics of Cerebral Palsy in the Midwestern US

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebral palsy (CP) is the most common lifelong motor disability worldwide. Yet, data is limited on how CP manifests in the US. Our objective was to characterize and determine factors affecting functional outcomes in a large population of young people with CP in the Midwestern US.
Susie Kim, Kelsey Steffen, Lauren Gottschalk‐Henneberry, Jennifer Miros, Amy Robichaux‐Viehoever, Karen Taca, Bhooma R. Aravamuthan   +6 more
wiley   +1 more source

Renqing Changjue alleviates sepsis-induced acute lung injury by regulating renin-angiotensin system and inhibiting inflammatory response

Immunobiology
Sepsis, with high morbidity and mortality, represents a systemic inflammatory response syndrome. A common consequence of sepsis is acute lung injury (ALI).
Minxia Zhu, Yaqi Lei, Zhaojun Zhang, Xu Guo, Jing Guo, Ruipeng Wu, Xiaofeng Li, Shibo Tian, Yuanhao Zhao   +8 more
doaj   +1 more source

HIF-1α Contributes to Hypoxia-induced Invasion and Metastasis of Esophageal Carcinoma via Inhibiting E-cadherin and Promoting MMP-2 Expression [PDF]

, 2012
Hypoxia-inducible factor-1α (HIF-1α) has been found to enhance tumor invasion and metastasis, but no study has reported its action in esophageal carcinoma.
Cheng, Yun-Jie, Jing, Shao-Wu, Kuroda, Masahiro, Liu, Qing, Su, Jing-Wei, Sun, Guo-Gui, Wang, Ya-Di, Yang, Cong-Rong   +7 more
core   +1 more source

Change in Cognition Following Ischaemic Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline can occur following ischaemic stroke. How cognition changes over time and associations with cognitive change are poorly understood. This study aimed to explore these issues over 2 years following ischaemic stroke.
Wenci Yan, Terence Quinn, Alex McConnachie, Niall Broomfield, Yun Wong, David Dickie, Kirsten Forbes, Matthew Walters, Jesse Dawson   +8 more
wiley   +1 more source

1H-NMR urine metabolomic fingerprint for severity discrimination in pulmonary sarcoidosis

ERJ Open Research
Background Sarcoidosis is a systemic inflammatory immune disease characterised by noncaseating granulomas. Its course can vary from benign to very severe, requiring appropriate treatment.
Florence Jeny, Mohamed Nawfal Triba, Simon Chauveau, Dominique Valeyre, Sabrina Mokhtari, Hilario Nunes, Jean-Francois Bernaudin, Philippe Savarin   +7 more
doaj   +1 more source

The hypoxic transcription factor KlMga2 mediates the response to oxidative stress and influences longevity in the yeast Kluyveromyces lactis [PDF]

, 2019
Hypoxia is defined as the decline of oxygen availability, depending on environmental supply and cellular consumption rate. The decrease in O2 results in reduction of available energy in facultative aerobes.
Bianchi, Michele M, Brambilla, Luca, Camponeschi, Ilaria, Immesi, Alessio, Mazzoni, Cristina, Polo, Germano, Rinaldi, Teresa, Santomartino, Rosa   +7 more
core   +1 more source

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu, Oliver Robinson, Christina M. Lill, Anna Matton, Raquel Puerta, Pilar Sanz, Merce Boada, Agustín Ruiz, Lefkos Middleton, for the Alzheimer's Disease Neuroimaging Initiative   +9 more
wiley   +1 more source