Results 81 to 90 of about 662,957 (307)

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

1H-NMR urine metabolomic fingerprint for severity discrimination in pulmonary sarcoidosis

ERJ Open Research
Background Sarcoidosis is a systemic inflammatory immune disease characterised by noncaseating granulomas. Its course can vary from benign to very severe, requiring appropriate treatment.
Florence Jeny, Mohamed Nawfal Triba, Simon Chauveau, Dominique Valeyre, Sabrina Mokhtari, Hilario Nunes, Jean-Francois Bernaudin, Philippe Savarin   +7 more
doaj   +1 more source

Hypoxia-sensitive glycolytic genes are not affected by BCP.

, 2023
RNAseq data (GSE125511), generated from cells exposed to hypoxic conditions in the presence or absence of BCP, were queried for hypoxic-sensitive glycolytic genes.
Susan C. Frost (2918471), Christopher J. Frost (14768787), Andrea Ramirez-Mata (14768790), Matthew E. Merritt (2193844), Ram B. Khattri (7438388)   +4 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Salidroside inhibited the proliferation of gastric cancer cells through up-regulating tumor suppressor miR-1343-3p and down-regulating MAP3K6/MMP24 signal molecules

Cancer Biology & Therapy
Salidroside inhibited the proliferation of cancer cell. Nevertheless, the mechanism has not been completely clarified. The purpose of the study is to explore the mechanisms of salidroside against gastric cancer. To analyze the changes of microRNA (miRNA)
Xiaoping Wang, Zhendong Zhang, Xiaolan Cao   +2 more
doaj   +1 more source

Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation. [PDF]

, 2014
Sustained hypoxemia is associated with insulin resistance, whose magnitude correlates with the degree of oxidative stress and inflammation. The role of 4-HNE and IL-6 as key players in modifying the association between sustained hypoxia and insulin ...
Monty G. Mythen (551722), Carl A Leckstrom, Mythen, Monty G., Mario Siervo, Hugh E Montgomery, Monty G Mythen, Fernandez, Bernadette O, Feelisch, Martin, Bernadette O. Fernandez (358499), Kay Mitchell, Martin Feelisch, Siervo, Mario, Riley, Heather L., Fernandez, Bernadette O., Montgomery, Hugh E., Martin Feelisch (358503), Michael P W Grocott, Heather L. Riley (551717), HASH(0x55a67fe3ce10), Michael P. W. Grocott (551723), Denny Z H Levett, Caudwell Xtreme Everest Research Group, Mario Siervo (359964), Denny Z. H. Levett (551721), Carl A. Leckstrom (551718), Levett, Denny Z.H., Bernadette O Fernandez, Daniel S Martin, Hugh E. Montgomery (364638), Grocott, Michael P. W., Levett, Denny Z. H., Leckstrom, Carl A., Martin, Daniel S., Kay Mitchell (551720), Daniel S. Martin (551719), Mitchell, Kay, Heather L Riley, Fernandez Bernadette O., Grocott Michael P. W., Montgomery Hugh E., Leckstrom Carl A., Siervo Mario, Mitchell Kay, Feelisch Martin, Martin Daniel S., Riley Heather L., Mythen Monty G., Levett Denny Z. H.   +47 more
core   +2 more sources

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Hooray for Hypoxia?

PLoS Medicine, 2005
The mortality of critically ill patients rises steadily as the partial pressure of arterial oxygen falls below about 11 kPa (80 mm Hg). A new animal study in the May 2005 issue of PLoS Biology showing a potential benefit for hypoxia is thus a challenge to current thinking.
openaire   +6 more sources

Inspiratory muscle training and its effect on indices of physiological and perceived stress during incremental walking exercise in normobaric hypoxia [PDF]

, 2014
This study evaluated the effects of inspiratory muscle training (IMT) on inspiratory muscle fatigue (IMF) and physiological and perceptual responses during trekking-specific exercise. An 8-week IMT program was completed by 21 males (age 32.4 – 9.61 years,
MALACRIDA S, BARTESAGHI M, Seims, A, Cooke, CB, MILLINO, CATERINA, O'Hara, J, PRATALI L, LAVEDER, PAOLO, CELEGATO, BARBARA, King, R, GIARDINI G, PACCHIONI, BENIAMINA, LANFRANCHI, GEROLAMO, VERRATTI, Vittore, DI GIULIO, Camillo, Santoro, Michele Matteo, Iaboni, Martina, Di Mari, Walter, Luana P, DIVERIO, Silvana, Aloisi AM, Dallo, Federico, Barbante, Carlo, Gabrieli, Jacomo   +23 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source