Results 241 to 250 of about 4,650,121 (384)

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

A Review of HIF-1α-Mediated Integration of Metabolic Reprogramming, Mitochondrial Function, and PI3K/Akt-MAPK-Nrf2-NF-κB Signaling. [PDF]

Antioxidants (Basel)
Ashraf A, Bruce ED.
europepmc   +1 more source

Environmental versus functional hypoxia/anoxia in sole Solea solea:the lactate paradox revisited [PDF]

, 1997
Josef Dalla Via, Guido van den Thillart, Otello Cattani, P. Cortesi   +3 more
openalex   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Sex-sensitive and insensitive endocrine responses and infradian changes while trekking in the Himalayas. [PDF]

Pflugers Arch
Bondi D, Bonan S, Cantarelli S, Ietta F, Casini I, Taverna A, Rua R, Guagnano MT, Barbonetti A, Bhandari S, Shrestha A, Aloisi AM, Verratti V.   +12 more
europepmc   +1 more source

Acute environmental hypoxia potentiates satellite cell‐dependent myogenesis in response to resistance exercise through the inflammation pathway in human

, 2019
Florian Britto, Olouyoumi Gnimassou, Estelle De Groote, Estelle Balan, Geoffrey Warnier, Amandine Everard, Patrice D. Cani, Louise Deldicque   +7 more
openalex   +2 more sources

Hif-1α/Hsf1/Hsp70 signaling pathway regulates redox homeostasis and apoptosis in large yellow croaker (<i>Larimichthys crocea</i>) under environmental hypoxia

, 2021
Shengyu Luo, 宁波大学海洋学院教育部应用海洋生物技术重点实验室, 浙江 宁波 315211, 中国, Jingqian Wang, Cheng Liu, Xinming Gao, Yibo Zhang, Jie Ding, Cong-Cong Hou, Junquan Zhu, Bao Lou, Weiliang Shen, Xiongfei Wu, Chundan Zhang, Daojun Tang, 浙江省农业科学院, 浙江 杭州 310021, 中国, 宁波市海洋与渔业研究院大黄鱼育种国家重点实验室, 浙江 宁波 315012, 中国   +15 more
openalex   +1 more source

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

Insights into enhanced, divergent, and additive responses to single and combined hypoxia-salt stress. [PDF]

BMC Plant Biol
Jordine A, Alt J, Bonn C, Nolte P, van Dongen JT, Fürtauer L.   +5 more
europepmc   +1 more source

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

Advanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang, Haowei Fang, Lili Qi, Song Myoungseop, Aawrish Khan, Lunli Gong, Guangdong Zhou, Kunxi Zhang, Haiyan Cui   +8 more
wiley   +1 more source