Results 301 to 310 of about 4,147,965 (342)

Gut microbiome, stress and interventional strategies using hardy animals. [PDF]

Future Sci OA
Siddiqui R, Qaisar R, Maciver S, Khan NA.   +3 more
europepmc   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

The effects of graded hypoxia on gene expression related to oxygen sensing and metabolism. [PDF]

Sci Rep
Walker J, Ruby B, Slivka D.
europepmc   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Genomic differentiation between wild and domesticated populations of large yellow croaker (Larimichthys crocea): environmental impacts. [PDF]

BMC Genomics
Jiang L, Gao X, Zhang K, Xu K, Zheng J, Liu L, Song W, Chen S, Yan X.   +8 more
europepmc   +1 more source

Effects of the interaction of environmental factors (hypoxia and ammonia) on fish

, 2013
Timothy M. Parker
openalex   +1 more source

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Chronic hypoxia induces liver injury via PKCδ/ASMase-driven ceramide accumulation and endoplasmic reticulum stress in rats. [PDF]

Lipids Health Dis
Huang Y, Ding Y, Guo X, Huang L, Meng X, Jiang W, Wang Z, Yang T, Zheng M, Tan X.   +9 more
europepmc   +1 more source

Metabolic Consequences of Hybridization in European Water Frogs (<i>Pelophylax esculentus</i> complex). [PDF]

Ecol Evol
Hermaniuk A, Czajkowska M, Pabijan M, Verberk WCEP, Czarnoleski M.   +4 more
europepmc   +1 more source

Monge's disease at 100 years: Revisiting the origins and endocrine mechanisms of chronic mountain sickness. [PDF]

Sci Prog
Gonzales GF.
europepmc   +1 more source