Results 141 to 150 of about 343,763 (246)

Physiologically Based Pharmacokinetic Modeling to Characterize the Disposition of Topiramate in Children with and without Obesity

The Journal of Clinical Pharmacology, Volume 66, Issue 10, October 2026.
Abstract Topiramate (TPM) is used to treat seizures in adults and children ≥2 years. In children, TPM dosing is body weight based. It is unknown whether children with obesity may benefit from an alternative dosing strategy. We developed a novel physiologically based pharmacokinetic (PBPK) model for TPM that accounts for age‐ and obesity‐related changes
Patricia D. Maglalang, Daniel Gonzalez, William J. Muller, Chi D. Hornik, Stuart L. Goldstein, Mobeen Rathore, Jennifer L. Ford, Stephen J. Balevic, Jaydeep Sinha, Andrea Edginton, Rachel G. Greenberg, Daniel K. Benjamin, Jia‐Yuh Chen, Kanecia O. Zimmerman, the Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee   +14 more
wiley   +1 more source

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Antenatal Prediction of Shoulder Dystocia and Birth Trauma Using Routine Maternal and Ultrasound Variables: Retrospective Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 11, Page 1996-2002, October 2026.
ABSTRACT Objective To develop antenatal prediction models for shoulder dystocia and birth trauma using routinely collected maternal and sonographic variables. Design Retrospective cohort study. Setting Single tertiary referral centre in the UK. Population or Sample All singleton term liveborn pregnancies delivered between January 2016 and November 2024
Anat Schwartz, Monica Minopoli, Chiara Di Ilio, Daniele Di Mascio, Amaranth Bhide, Basky Thilaganathan   +5 more
wiley   +1 more source

The Panorama of Cerebral Palsy in Sweden Part XIV Shows Further Decrease in Prevalence and Severity in the Birth‐Years 2015–2018

Acta Paediatrica, Volume 115, Issue 10, Page 2149-2158, October 2026.
ABSTRACT Aim To describe prevalence, background and gross motor function of cerebral palsy (CP) in western Sweden 2015–2018 and compare to birth‐years 1999–2014. Methods Population‐based study covering 108 963 live births in 2015–2018. Birth characteristics, neuroimaging findings and motor outcome were analysed and prevalence calculated and compared to
Kate Himmelmann, Magnus Påhlman
wiley   +1 more source

No Association Between Umbilical Cord pH and Special Educational Needs Among Children With Normal 5‐Minute Apgar Scores

Acta Paediatrica, Volume 115, Issue 10, Page 2200-2208, October 2026.
ABSTRACT Aim Most infants with a low cord pH have reassuring 5‐min Apgar scores of 7–10, but their long‐term outcomes have been poorly studied. We examined whether cord pH predicted later special educational needs (SEN). Method This nationwide register‐based study was conducted in Denmark, which provides universal cord pH screening.
Celina Myrhøj, Harman Yonis, Rikke Wiingreen, Ellen Christine Leth Løkkegaard, Christian Torp‐Pedersen, Bo Mølholm Hansen   +5 more
wiley   +1 more source

Hammersmith Infant Neurological Examination for early detection of cerebral palsy in Ethiopia: A feasibility and knowledge translation study

Developmental Medicine &Child Neurology, Volume 68, Issue 10, Page 1432-1439, October 2026.
The Hammersmith Infant Neurological Examination (HINE) can be successfully implemented in low‐resource tertiary care settings. Paediatric residents facilitated the implementation of HINE. Early detection of cerebral palsy and referral at an average age of 10.6 months in Ethiopia were achieved.
Selamenesh Tsige Legas, Atsede Teklehaimanot, Behaylu Yibe, Amber Makino, Rudaina Banihani, Amha Mekasha, Ayalew Moges, Asrat Demtse, Darcy Fehlings   +8 more
wiley   +1 more source

Transfusion Burden in Neonates with Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia. [PDF]

Children (Basel)
De Rose DU, Maddaloni C, Ronci S, Campi F, Caoci S, Martini L, Bersani I, Savarese I, Capolupo I, Longo D, Berti P, Porzio O, Luciani M, Dotta A.   +13 more
europepmc   +1 more source

Impact of a Specialized Care Pathway for ICU Patients With Disorders of Consciousness: Observational Insights From an Expert Center

European Journal of Neurology, Volume 33, Issue 10, October 2026.
In a cohort of 124 patients from 37 ICUs referred to an expert center for lasting disorders of consciousness, specialized multimodal consciousness assessment impacted the ethical decisions made by primary centers and helped to refine the prediction of recovery but without highly accurate individual prediction in a population with overall poor survival ...
Clément Caiazzo, Estelle Pruvost‐Robieux, Ghazi Hmeydia, Eleonore Bouchereau, Camille Legouy, Charlotte Calligaris, Julie Lévi‐Strauss, Catherine Oppenheim, Sarah Benghanem, Caroline Schimpf, Martine Gavaret, Tarek Sharshar, Bertrand Hermann   +12 more
wiley   +1 more source

Cannabidiol in Adults With Lennox–Gastaut Syndrome: Real‐World Experience

European Journal of Neurology, Volume 33, Issue 10, October 2026.
Cannabidiol showed sustained effectiveness and good tolerability in adults with LGS, with high retention over a median follow‐up of 41 months. Treatment was associated with improvement in seizure burden, increased seizure‐free days, fewer seizure‐related hospital admissions, and caregiver‐reported improvement in cognitive and behavioural functioning ...
Pyae Aung, Debbie Miller, Emily Sewell, Laura Mantoan Ritter, Evangelia Theochari, Ioannis Stavropoulos, Robert Delamont, Mark P. Richardson, Joel S. Winston, Lina Nashef   +9 more
wiley   +1 more source

NLRP3 Regulation in Neonatal Hypoxic-Ischemic Encephalopathy-Focus on Microglial Activation. [PDF]

Int J Mol Sci
Burkard H, Bernis ME, Bremer AS, Maes E, Walter J, Meissner F, Sabir H.   +6 more
europepmc   +1 more source