Results 1 to 10 of about 63,439 (118)

Neuroinflammation mediates the progression of neonate hypoxia-ischemia brain damage to Alzheimer’s disease: a bioinformatics and experimental study [PDF]

Frontiers in Aging Neuroscience
BackgroundTraumatic brain injury (TBI) can generally be divided into focal damage and diffuse damage, and neonate Hypoxia-Ischemia Brain Damage (nHIBD) is one of the causes of diffuse damage.
Shengjie Zhang, Ruqiu Zhang, Zhaoqin Chen, Zihan Shao, An Li, Fan Li, Fang Huang   +6 more
doaj   +2 more sources

Exenatide Is Neuroprotective in a New Rabbit Model of Hypoxia-Ischemia [PDF]

Cells
Hypoxia-ischemia is a serious perinatal complication affecting neonates globally. Animal models have increased the understanding of its pathophysiology and have been used to investigate potential therapies. Exenatide, clinically used for the treatment of
Eridan Rocha-Ferreira, Malin Carlsson, Pernilla Svedin, Kerstin Ebefors, Owen Herrock, Anna-Lena Leverin, Henrik Hagberg   +6 more
doaj   +2 more sources

Repurposed Edaravone, Metformin, and Perampanel as a Potential Treatment for Hypoxia–Ischemia Encephalopathy: An In Vitro Study

Biomedicines, 2022
Hypoxia–ischemia encephalopathy results from the interruption of oxygen delivery and blood flow to the brain. In the developing brain, it can lead to a brain injury, which is associated with high mortality rates and comorbidities.
Daniela Silva, Ruben Rocha, Ana Salomé Correia, Bárbara Mota, Maria Dulce Madeira, Nuno Vale, Armando Cardoso   +6 more
doaj   +1 more source

Neuronal vulnerability to fetal hypoxia-reoxygenation injury and motor deficit development relies on regional brain tetrahydrobiopterin levels

Redox Biology, 2020
Hypertonia is pathognomonic of cerebral palsy (CP), often caused by brain injury before birth. To understand the early driving events of hypertonia, we utilized magnetic resonance imaging (MRI) assessment of early critical brain injury in rabbit fetuses (
Jeannette Vasquez-Vivar, Zhongjie Shi, Jeong-Won Jeong, Kehuan Luo, Amit Sharma, Karthikeyan Thirugnanam, Sidhartha Tan   +6 more
doaj   +1 more source

Circulating tight-junction proteins are potential biomarkers for blood–brain barrier function in a model of neonatal hypoxic/ischemic brain injury

Fluids and Barriers of the CNS, 2021
Background Neonatal encephalopathy often leads to lifelong disabilities with limited treatments currently available. The brain vasculature is an important factor in many neonatal neurological disorders but there is a lack of diagnostic tools to evaluate ...
E. Axel Andersson, Carina Mallard, C. Joakim Ek   +2 more
doaj   +1 more source

Therapeutic Effect of Nicotinamide Mononucleotide for Hypoxic–Ischemic Brain Injury in Neonatal Mice

ASN Neuro, 2023
A clinical challenge remains in the treatment of hypoxic–ischemic brain injury in newborns. Nicotinamide adenine dinucleotide (NAD + ) has beneficial effects in animal models of adult stroke.
Takuya Kawamura, Gagandeep Singh Mallah, Maryam Ardalan, Tetyana Chumak, Pernilla Svedin, Lina Jonsson, Seyedeh Marziyeh Jabbari Shiadeh, Fanny Goretta, Tomoaki Ikeda, Henrik Hagberg, Mats Sandberg, Carina Mallard   +11 more
doaj   +1 more source

Neuroprotective Effects of Mitochondria-Targeted Plastoquinone in a Rat Model of Neonatal Hypoxic–Ischemic Brain Injury

Molecules, 2018
Neonatal hypoxia–ischemia is one of the main causes of mortality and disability of newborns. To study the mechanisms of neonatal brain cell damage, we used a model of neonatal hypoxia–ischemia in seven-day-old rats, by annealing of the common
Denis N. Silachev, Egor Y. Plotnikov, Irina B. Pevzner, Ljubava D. Zorova, Anastasia V. Balakireva, Mikhail V. Gulyaev, Yury A. Pirogov, Vladimir P. Skulachev, Dmitry B. Zorov   +8 more
doaj   +1 more source

Tetrahydrobiopterin in antenatal brain hypoxia-ischemia-induced motor impairments and cerebral palsy

Redox Biology, 2017
Antenatal brain hypoxia-ischemia, which occurs in cerebral palsy, is considered a significant cause of motor impairments in children. The mechanisms by which antenatal hypoxia-ischemia causes brain injury and motor deficits still need to be elucidated ...
Jeannette Vasquez-Vivar, Zhongjie Shi, Kehuan Luo, Karthikeyan Thirugnanam, Sidhartha Tan   +4 more
doaj   +1 more source

Disruption of the Serotonergic System after Neonatal Hypoxia-Ischemia in a Rodent Model

Neurology Research International, 2012
Identifying which specific neuronal phenotypes are vulnerable to neonatal hypoxia-ischemia, where in the brain they are damaged, and the mechanisms that produce neuronal losses are critical to determine the anatomical substrates responsible for ...
Kathryn M. Buller, Julie A. Wixey, Hanna E. Reinebrant   +2 more
doaj   +1 more source

Hypoxic Preconditioning Suppresses Glial Activation and Neuroinflammation in Neonatal Brain Insults

Mediators of Inflammation, 2015
Perinatal insults and subsequent neuroinflammation are the major mechanisms of neonatal brain injury, but there have been only scarce reports on the associations between hypoxic preconditioning and glial activation.
Chien-Yi Chen, Wei-Zen Sun, Kai-Hsiang Kang, Hung-Chieh Chou, Po-Nien Tsao, Wu-Shiun Hsieh, Wen-Mei Fu   +6 more
doaj   +1 more source