Results 31 to 40 of about 1,949,320 (295)
Journal of Pharmacological Sciences, 2021 The blood–brain barrier (BBB) is mainly formed by brain capillary endothelial cells (BCECs) and is exposed to hypoxic environments under pathological conditions. The effects of hypoxia on the expression and activity of Ca2+-activated Cl− (ClCa) channels,
Takahisa Suzuki +4 more
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The spectrum of Ischemia-induced white matter injury varies with age [PDF]
, 2013 Stroke is a neurological condition that targets the whole range of the human population, from the pre-term infant to the elderly and is a major cause of death worldwide (Ingall 2004).
Zammit, Christian +2 more
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17β-Estradiol protects the neonatal brain from hypoxia–ischemia [PDF]
Experimental Neurology, 2007 Hypoxia-ischemia is relatively common in human infants. Hypoxia-ischemia can occur as a result of complications associated with prematurity or birth, frequently leading to altered brain development and cognitive and behavioral deficits that persist throughout life. Despite the relative frequency of neonatal hypoxic-ischemic encephalopathy, the immature
Joseph, Nuñez +5 more
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Neurobiology of Disease, 2006 The aim of the present study is to better understand oxygen-sensitive adaptative pathways underlying the hypoxic preconditioning-induced protection of the brain against ischemia.
Yang Tang +6 more
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Cortical organotypic slice cultures as a tool to analyze the neurovascular unit in hypoxia/ischemia and hypothermia-induced neuroprotection [PDF]
, 2013 Neurons and glial cells of the central nervous system (CNS) communicate and work together to function and execute an array of complex tasks. In addition to them a third cell type which also works to keep the brain alive are the cerebral endothelial cells
Chip, Sophorn
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Sex‐dependent consequences of neonatal brain hypoxia‐ischemia in the rat [PDF]
Journal of Neuroscience Research, 2016 Neonatal hypoxia‐ischemia (HI) is an important cause of neurological deficits in humans, and the Levine‐Rice model of experimental HI in the rat mimics the human brain lesion and the following sensory motor deficits and cognitive disabilities. With the growing evidence that sex influences all levels of brain functions, this Mini‐Review highlights ...
Netto CA +4 more
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Frontiers in Physiology, 2012 As clinicians attempt to understand the underlying reasons for the vulnerability of different regions of the developing brain to injury, it is apparent that little is known as to how hypoxia-ischemia may affect the cerebrovasculature in the developing ...
Ana eBaburamani +5 more
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Biomolecules, 2020 Damage to cerebral mitochondria, particularly opening of mitochondrial permeability transition pore (MPTP), is a key mechanism of ischemic brain injury, therefore, modulation of MPTP may be a potential target for a neuroprotective strategy in ischemic ...
Kristina Skemiene +5 more
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Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2 [PDF]
, 2006 FGF-2, a potent multifunctional and neurotrophic growth factor, is widely expressed in the brain and upregulated in cerebral ischemia. Previous studies have shown that intraventricularly or systemically administered FGF-2 reduces the size of cerebral ...
Kiprianova, Irina +6 more
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Alterations of CaMKII after hypoxia‐ischemia during brain development [PDF]
Journal of Neurochemistry, 2004 AbstractTransient brain hypoxia‐ischemia (HI) in neonates leads to delayed neuronal death and long‐term neurological deficits. However, the underlying mechanisms are incompletely understood. Calcium‐calmodulin‐dependent protein kinase II (CaMKII) is one of the most abundant protein kinases in neurons and plays crucial roles in synaptic development and ...
Kaixiong, Tang +3 more
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