Results 31 to 40 of about 93,068 (305)

Inhaled 45–50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia

Neurobiology of Disease, 2016
Cooling to 33.5 °C in babies with neonatal encephalopathy significantly reduces death and disability, however additional therapies are needed to maximize brain protection.
Kevin D. Broad, Igor Fierens, Bobbi Fleiss, Eridan Rocha-Ferreira, Mojgan Ezzati, Jane Hassell, Daniel Alonso-Alconada, Alan Bainbridge, Go Kawano, Daqing Ma, Ilias Tachtsidis, Pierre Gressens, Xavier Golay, Robert D. Sanders, Nicola J. Robertson   +14 more
doaj   +1 more source

Cortical organotypic slice cultures as a tool to analyze the neurovascular unit in hypoxia/ischemia and hypothermia-induced neuroprotection [PDF]

, 2013
Neurons and glial cells of the central nervous system (CNS) communicate and work together to function and execute an array of complex tasks. In addition to them a third cell type which also works to keep the brain alive are the cerebral endothelial cells
Chip, Sophorn
core   +1 more source

17β-Estradiol protects the neonatal brain from hypoxia–ischemia [PDF]

Experimental Neurology, 2007
Hypoxia-ischemia is relatively common in human infants. Hypoxia-ischemia can occur as a result of complications associated with prematurity or birth, frequently leading to altered brain development and cognitive and behavioral deficits that persist throughout life. Despite the relative frequency of neonatal hypoxic-ischemic encephalopathy, the immature
Joseph, Nuñez, Zhengang, Yang, Yuhui, Jiang, Theresa, Grandys, Ilana, Mark, Steven W, Levison   +5 more
openaire   +2 more sources

Effect of hypoxic preconditioning on brain genomic response before and following ischemia in the adult mouse: Identification of potential neuroprotective candidates for stroke

Neurobiology of Disease, 2006
The aim of the present study is to better understand oxygen-sensitive adaptative pathways underlying the hypoxic preconditioning-induced protection of the brain against ischemia.
Yang Tang, Emilie Pacary, Thomas Fréret, Didier Divoux, Edwige Petit, Pascale Schumann-Bard, Myriam Bernaudin   +6 more
doaj   +1 more source

Comparison of Effects of Metformin, Phenformin, and Inhibitors of Mitochondrial Complex I on Mitochondrial Permeability Transition and Ischemic Brain Injury

Biomolecules, 2020
Damage to cerebral mitochondria, particularly opening of mitochondrial permeability transition pore (MPTP), is a key mechanism of ischemic brain injury, therefore, modulation of MPTP may be a potential target for a neuroprotective strategy in ischemic ...
Kristina Skemiene, Evelina Rekuviene, Aiste Jekabsone, Paulius Cizas, Ramune Morkuniene, Vilmante Borutaite   +5 more
doaj   +1 more source

Sex‐dependent consequences of neonatal brain hypoxia‐ischemia in the rat [PDF]

Journal of Neuroscience Research, 2016
Neonatal hypoxia‐ischemia (HI) is an important cause of neurological deficits in humans, and the Levine‐Rice model of experimental HI in the rat mimics the human brain lesion and the following sensory motor deficits and cognitive disabilities. With the growing evidence that sex influences all levels of brain functions, this Mini‐Review highlights ...
Carlos Alexandre, Netto, Eduardo, Sanches, Felipe Kawa, Odorcyk, Luz Elena, Duran-Carabali, Simone Nardin, Weis   +4 more
openaire   +2 more sources

Vulnerability of the Developing Brain to Hypoxic-Ischemic Damage: Contribution of the Cerebral Vasculature to Injury and Repair?

Frontiers in Physiology, 2012
As clinicians attempt to understand the underlying reasons for the vulnerability of different regions of the developing brain to injury, it is apparent that little is known as to how hypoxia-ischemia may affect the cerebrovasculature in the developing ...
Ana eBaburamani, Ana eBaburamani, C. Joakim eEk, David W. Walker, David W. Walker, Margie eCastillo-Melendez   +5 more
doaj   +1 more source

Alterations of CaMKII after hypoxia‐ischemia during brain development [PDF]

Journal of Neurochemistry, 2004
AbstractTransient brain hypoxia‐ischemia (HI) in neonates leads to delayed neuronal death and long‐term neurological deficits. However, the underlying mechanisms are incompletely understood. Calcium‐calmodulin‐dependent protein kinase II (CaMKII) is one of the most abundant protein kinases in neurons and plays crucial roles in synaptic development and ...
Kaixiong, Tang, Chunli, Liu, John, Kuluz, Bingren, Hu   +3 more
openaire   +2 more sources

The effects of hyperglycaemic hypoxia on rectification in rat dorsal root axons [PDF]

, 1994
1. Electrotonic responses to 150 ms current pulses were recorded from isolated rat dorsal roots incubated for at least 3 h with either normal (5 mM) or high (25 mM) D-glucose solutions, and with either normal (25 mM) or low (5 mM) bicarbonate ...
U Schneider, H Bostock, Schneider, Uwe, Grafe, Peter, Bostock, Hugh, P Grafe   +5 more
core   +1 more source

Changes in arginase isoforms in a murine model of neonatal brain hypoxia–ischemia [PDF]

Pediatric Research, 2020
Arginases (ARG isoforms, ARG-1/ARG-2) are key regulatory enzymes of inflammation and tissue repair; however, their role after neonatal brain hypoxia (H) and hypoxia-ischemia (HI) remains unknown.C57BL/6 mice subjected to the Vannucci procedure on postnatal day (P9) were sacrificed at different timepoints.
Mike, Jana K, Pathipati, Praneeti, Sheldon, R Ann, Ferriero, Donna M   +3 more
openaire   +4 more sources