Results 51 to 60 of about 93,068 (305)

MerTK and the Role of Phagoptosis in Neonatal Hypoxia-Ischemia

Cells
Brain damage caused by hypoxia-ischemia is a serious complication for a newborn with possible life-long sequelae. To develop targeted neuroprotective strategies, it is essential to understand the mechanisms of injury, particularly the role of microglial ...
Andrea Jonsdotter, Henrik Hagberg, Anna-Lena Leverin, Joakim Ek, Kerstin Ebefors, Eridan Rocha-Ferreira, Ylva Carlsson   +6 more
doaj   +1 more source

The GluN3A Subunit Exerts a Neuroprotective Effect in Brain Ischemia and the Hypoxia Process

ASN Neuro, 2013
NMDARs ( N -methyl-d-aspartate receptors) mediate the predominantly excitatory neurotransmission in the CNS (central nervous system). Excessive release of glutamate and overactivation of NMDARs during brain ischemia and the hypoxia process are causally ...
Hui Wang, Haitao Yan, Shuzhuo Zhang, Xiaoli Wei, Jianquan Zheng, Jin Li   +5 more
doaj   +1 more source

Rodent Hypoxia Ischemia Models for Cerebral Palsy Research: A Systematic Review

Frontiers in Neurology, 2016
Cerebral Palsy (CP) is a complex multifactorial disorder, affecting approximately 2.5-3 per 1000 live term births, and up to 22 per 1000 prematurely born babies. CP results from injury to the developing brain incurred before, during or after birth.
Prakasham eRumajogee, Tatiana eBregman, Steven eMiller, Jerome Y Yager, Michael eFehlings, Michael eFehlings   +5 more
doaj   +1 more source

Prednisolone as preservation additive prevents from ischemia reperfusion injury in a rat model of orthotopic lung transplantation

, 2013
The lung is, more than other solid organs, susceptible for ischemia reperfusion injury after orthotopic transplantation. Corticosteroids are known to potently suppress pro-inflammatory processes when given in the post-operative setting or during ...
Haitham Mutlak, Paulus, Patrick, Mutlak, Haitham, Johannes Holfeld, Haitham Mutlak (452006), Sabine Tacke (318720), David Stay (452009), Patrick Paulus, Holfeld, Johannes, Urbschat, Anja, Christin Reissig, Pia Alexandra Ockelmann, Reissig, Christin, Zacharowski, Kai, Tacke, Sabine, Bertram Scheller (318724), Stay, David, Bertram Scheller, Ockelmann, Pia Alexandra, Scheller, Bertram, Kai Zacharowski (77285), Sabine Tacke, Johannes Holfeld (318725), Patrick Paulus (318716), Anja Urbschat, Kai Zacharowski, Christin Reissig (452008), Anja Urbschat (318726), David Stay, Pia Alexandra Ockelmann (452007)   +29 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

NLRP3 inflammasome: a key player in neonatal brain injury [PDF]

Clinical and Experimental Pediatrics
Among neonates, hypoxic-ischemic encephalopathy is the most significant cause of mortality and hypoxia-ischemia is among the leading causes of brain damage. The microglia are primary mediators of neuroinflammation.
Cagla Kiser, Ilkcan Ercan, Defne Engur, Sermin Genc   +3 more
doaj   +1 more source

Differential effects of HIF-1 inhibition by YC-1 on the overall outcome and blood-brain barrier damage in a rat model of ischemic stroke. [PDF]

PLoS ONE, 2011
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of cellular adaptation to hypoxia and has been suggested as a potent therapeutic target in cerebral ischemia.
Jingqi Yan, Bo Zhou, Saeid Taheri, Honglian Shi   +3 more
doaj   +1 more source

Involvement of Nitric Oxide in Microcirculatory Reactions after Ischemia-Reperfusion of the Rat Urinary Bladder [PDF]

, 2009
Background: Nitric oxide ( NO) plays a role in inflammation. Our aim was to investigate the role of NO in the microcirculatory changes after ischemia-reperfusion (I/R) of the bladder using intravital videomicroscopy (IVM).
Bajory, Z., Pajor László, Kiraly, I., Szabó Andrea, Messmer Konrad, Király István, Pajor, L., Bajory Zoltán, Messmer, K., Szabo, A.   +9 more
core   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Hypoxia–ischemia is not an antecedent of most preterm brain damage: the illusion of validity [PDF]

Developmental Medicine & Child Neurology, 2017
Brain injury in preterm newborn infants is often attributed to hypoxia–ischemia even when neither hypoxia nor ischemia is documented, and many causative speculations are based on the same assumption. We review human and animal study contributions with their strengths and limitations, and conclude that – despite
Floyd Gilles, Pierre Gressens, Olaf Dammann, Alan Leviton   +3 more
openaire   +4 more sources