Results 51 to 60 of about 1,949,320 (295)

The change in the hypoxia resistance at chronic cerebral ischemia

Бюллетень сибирской медицины, 2008
Hypoxia and its related oxidate stress are the direct cause of the neural damage due to chronic cerebral ischemia. Resistance to hypoxia and oxidate stress is the main marker of the human and brain adaptation to chronic ischemia.Hypoxia resistance and ...
Ye. A. Antipenko, A. V. Gustov
doaj   +1 more source

MerTK and the Role of Phagoptosis in Neonatal Hypoxia-Ischemia

Cells
Brain damage caused by hypoxia-ischemia is a serious complication for a newborn with possible life-long sequelae. To develop targeted neuroprotective strategies, it is essential to understand the mechanisms of injury, particularly the role of microglial ...
Andrea Jonsdotter, Henrik Hagberg, Anna-Lena Leverin, Joakim Ek, Kerstin Ebefors, Eridan Rocha-Ferreira, Ylva Carlsson   +6 more
doaj   +1 more source

Added Prognostic Value of EEG Reactivity in Comatose Patients Following Cardiac Arrest

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the added prognostic value of EEG reactivity for favorable outcome compared with background analysis during and after targeted temperature management (TTM). Methods Prospective observational cohort study of comatose post–cardiac arrest patients admitted to a single academic center between 2017 and 2022, all undergoing ...
Sarah Caroyer, Marie Obrecht, Charlotte de Maeseneire, Charlotte Damien, Chantal Depondt, Lorenzo Ferlini, Estelle Rikir, Filippo Annoni, Fabio Silvio Taccone, Nicolas Mavroudakis, Benjamin Legros, Nicolas Gaspard   +11 more
wiley   +1 more source

Exenatide Is Neuroprotective in a New Rabbit Model of Hypoxia-Ischemia

Cells
Hypoxia-ischemia is a serious perinatal complication affecting neonates globally. Animal models have increased the understanding of its pathophysiology and have been used to investigate potential therapies. Exenatide, clinically used for the treatment of
Eridan Rocha-Ferreira, Malin Carlsson, Pernilla Svedin, Kerstin Ebefors, Owen Herrock, Anna-Lena Leverin, Henrik Hagberg   +6 more
doaj   +1 more source

The GluN3A Subunit Exerts a Neuroprotective Effect in Brain Ischemia and the Hypoxia Process

ASN Neuro, 2013
NMDARs ( N -methyl-d-aspartate receptors) mediate the predominantly excitatory neurotransmission in the CNS (central nervous system). Excessive release of glutamate and overactivation of NMDARs during brain ischemia and the hypoxia process are causally ...
Hui Wang, Haitao Yan, Shuzhuo Zhang, Xiaoli Wei, Jianquan Zheng, Jin Li   +5 more
doaj   +1 more source

Rodent Hypoxia Ischemia Models for Cerebral Palsy Research: A Systematic Review

Frontiers in Neurology, 2016
Cerebral Palsy (CP) is a complex multifactorial disorder, affecting approximately 2.5-3 per 1000 live term births, and up to 22 per 1000 prematurely born babies. CP results from injury to the developing brain incurred before, during or after birth.
Prakasham eRumajogee, Tatiana eBregman, Steven eMiller, Jerome Y Yager, Michael eFehlings, Michael eFehlings   +5 more
doaj   +1 more source

The role of endotoxin, the TNF family of cytokines and intracellular pH in perinatal hypoxic-ischemic brain injury [PDF]

, 2010
To explore the effect of endotoxin as a sensitising agent prior to neonatal hypoxiaischemia differing doses of endotoxin (E. coli lipopolysaccharide, LPS) were given to neonatal mice prior to hypoxia-ischemia, with sensitising effects noted at dosages ...
Kendall, G.
core  

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

The paradox between resistance to hypoxia and liability to hypoxic damage in hyperglycemic peripheral nerves. Evidence for glycolysis involvement [PDF]

, 1993
Isolated ventral and dorsal rat spinal roots incubated in normal (2.5 mM) or high glucose (25 mM) concentrations or in high concentrations of other hexoses were exposed transiently to hypoxia (30 min) in a solution of low buffering power.
Niedermeier, W., Schneider, Uwe, Grafe, Peter   +2 more
core   +1 more source

NLRP3 inflammasome: a key player in neonatal brain injury [PDF]

Clinical and Experimental Pediatrics
Among neonates, hypoxic-ischemic encephalopathy is the most significant cause of mortality and hypoxia-ischemia is among the leading causes of brain damage. The microglia are primary mediators of neuroinflammation.
Cagla Kiser, Ilkcan Ercan, Defne Engur, Sermin Genc   +3 more
doaj   +1 more source