Results 61 to 70 of about 1,949,320 (295)

Differential effects of HIF-1 inhibition by YC-1 on the overall outcome and blood-brain barrier damage in a rat model of ischemic stroke. [PDF]

PLoS ONE, 2011
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of cellular adaptation to hypoxia and has been suggested as a potent therapeutic target in cerebral ischemia.
Jingqi Yan, Bo Zhou, Saeid Taheri, Honglian Shi   +3 more
doaj   +1 more source

miR-127 protects proximal tubule cells against ischemia/reperfusion : identification of Kinesin family member 3B as miR-127 target [PDF]

, 2012
Ischemia/reperfusion (I/R) is at the basis of renal transplantation and acute kidney injury. Molecular mechanisms underlying proximal tubule response to I/R will allow the identification of new therapeutic targets for both clinical settings.
Cuppen, E., Bernhard Brüne, David Sáenz-Morales (139779), Konstantinos Stamatakis (139787), Stamatakis, K., Ramos, Edurne, Elisa Conde, Edurne Ramos (139777), Ramos, E., García Bermejo, María Laura, Blanco-Sanchez, I., Edwin Cuppen, Sáenz-Morales, David, Brune, B., Conde, E., Ignacio Blanco-Sánchez (139784), Bermejo, M.L., Luis del Peso (133134), Edwin Cuppen (9902), Stamatakis Andriani, Konstantinos, Stamatakis, Konstantinos, Peso, Luis del, del Peso, Luis, María Laura García Bermejo (139790), Saenz-Morales, D., Conde, Elisa, Konstantinos Stamatakis, María Laura García Bermejo, Edurne Ramos, Aguado-Fraile, Elia, Aguado-Fraile, E., del Peso, L., Ignacio Blanco-Sánchez, Blanco-Sánchez, Ignacio, Brüne, Bernhard, Bernhard Brüne (131193), Cuppen, Edwin, Elia Aguado-Fraile (139775), Elisa Conde (139781), Elia Aguado-Fraile, Luis del Peso, David Sáenz-Morales, Bermejo María Laura García, Sáenz-Morales David, García-Bermejo, María Laura, Aguado-Fraile Elia, del Peso Luis, Conde Elisa, Blanco-Sánchez Ignacio, Ramos Edurne, Brüne Bernhard, Stamatakis Konstantinos, Cuppen Edwin   +52 more
core   +2 more sources

Hypoxia–ischemia is not an antecedent of most preterm brain damage: the illusion of validity [PDF]

Developmental Medicine & Child Neurology, 2017
Brain injury in preterm newborn infants is often attributed to hypoxia–ischemia even when neither hypoxia nor ischemia is documented, and many causative speculations are based on the same assumption. We review human and animal study contributions with their strengths and limitations, and conclude that – despite
Floyd Gilles, Pierre Gressens, Olaf Dammann, Alan Leviton   +3 more
openaire   +4 more sources

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

THE ROLE OF NEUROGLOBIN IN CEREBRAL ISCHEMIA / HYPOXIA AND OTHER NEUROPATHOLOGY

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2018
The aim of the study was to summarize literature data on the localization, functions and role of neuroglobin in ischemia / hypoxia of the brain and neuropathology of different genesis.
Zimatkin S. M., Bon L. I., Maksimovich N. Ye.   +2 more
doaj   +1 more source

Effects of hypoxia and reoxygenation on mitochondrial functions and transcriptional profiles of isolated brain and muscle porcine cells

Scientific Reports, 2022
Oxygen fluctuations might occur in mammalian tissues under physiological (e.g. at high altitudes) or pathological (e.g. ischemia–reperfusion) conditions.
Linda Adzigbli, Eugene P. Sokolov, Klaus Wimmers, Inna M. Sokolova, Siriluck Ponsuksili   +4 more
doaj   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

Region-specific effects on brain metabolites of hypoxia and hyperoxia overlaid on cerebral ischemia in young and old rats: a quantitative proton magnetic resonance spectroscopy study

Journal of Biomedical Science, 2010
Background Both hypoxia and hyperoxia, deregulating the oxidative balance, may play a role in the pathology of neurodegenerative disorders underlain by cerebral ischemia.
Giuliani Patricia, Di Luzio Silvano, Di Iorio Patrizia, Di Giulio Camillo, D'Alessandro Nicola, Macri Maria A, Esposito Ennio, Pokorski Mieczyslaw   +7 more
doaj   +1 more source

STAT3 precedes HIF1α transcriptional responses to oxygen and oxygen and glucose deprivation in human brain pericytes. [PDF]

PLoS ONE, 2018
Brain pericytes are important to maintain vascular integrity of the neurovascular unit under both physiological and ischemic conditions. Ischemic stroke is known to induce an inflammatory and hypoxic response due to the lack of oxygen and glucose in the ...
Robert Carlsson, Ilknur Özen, Marco Barbariga, Abderahim Gaceb, Michaela Roth, Gesine Paul   +5 more
doaj   +1 more source