Global gene expression in the immature brain after hypoxia-ischemia [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2004 Ischemia induces a complex response of differentially expressed genes in the brain. In order to understand the specific mechanisms of injury in the developing brain, it is important to obtain information on global changes in the transcriptome after ...
Hagberg, Henrik, +4 more
core +4 more sources
Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]
Frontiers in Immunology, 2015 Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Rocha-Ferreira, E +5 more
core +5 more sources
The Arginase Pathway in Neonatal Brain Hypoxia-Ischemia. [PDF]
Developmental Neuroscience, 2018 Brain damage after hypoxia-ischemia (HI) occurs in an age-dependent manner. Neuroprotective strategies assumed to be effective in adults might have deleterious effects in the immature brain.
Krystofova, Jana +4 more
core +6 more sources
Effects of Acute Systemic Hypoxia and Hypercapnia on Brain Damage in a Rat Model of Hypoxia-Ischemia. [PDF]
PLoS ONE, 2016 Therapeutic hypercapnia has the potential for neuroprotection after global cerebral ischemia. Here we further investigated the effects of different degrees of acute systemic hypoxia in combination with hypercapnia on brain damage in a rat model of ...
Wanchao Yang +7 more
doaj +2 more sources
Inflammatory Gene Profiling in the Developing Mouse Brain after Hypoxia-Ischemia [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2004 Brain ischemia triggers an inflammatory reaction that progresses for days to weeks and seems to have a role in secondary progression of injury. Inflammation induces a complex pattern of signaling molecules with partly contradictory actions, and the ...
Carina Mallard +2 more
core +4 more sources
Analysis of GWAS-Derived Schizophrenia Genes for Links to Ischemia-Hypoxia Response of the Brain [PDF]
Frontiers in Psychiatry, 2020 Obstetric complications (OCs) can induce major adverse conditions for early brain development and predispose to mental disorders, including schizophrenia (SCZ).
Rainald Schmidt-Kastner +7 more
doaj +2 more sources
Up-Regulation of miR-9-5p Inhibits Hypoxia-Ischemia Brain Damage Through the DDIT4-Mediated Autophagy Pathways in Neonatal Mice. [PDF]
Drug Des Devel Ther, 2023 Chengcheng Gai,1,* Xiaohui Xing,1,2,* Yan Song,1 Yijing Zhao,1 Zige Jiang,1 Yahong Cheng,1 Yilei Xiao,2,3 Zhen Wang1,4 1Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong,
Gai C +7 more
europepmc +2 more sources
Impact of Hypoxia-Ischemia on Neurogenesis and Structural and Functional Outcomes in a Mild-Moderate Neonatal Hypoxia-Ischemia Brain Injury Model. [PDF]
Life (Basel), 2022 Hypoxic-ischemic encephalopathy (HIE) is a common type of brain injury caused by a lack of oxygen and blood flow to the brain during the perinatal period. The incidence of HIE is approximately 2–3 cases per 1000 live births in high-income settings; while in low- and middle-income countries, the incidence is 3–10-fold higher. Therapeutic hypothermia (TH)
Ehlting A +6 more
europepmc +5 more sources
Hypoxia–ischemia in the immature brain [PDF]
Journal of Experimental Biology, 2004 SUMMARYThe immature brain has long been considered to be resistant to the damaging effects of hypoxia and hypoxia–ischemia (H/I). However, it is now appreciated that there are specific periods of increased vulnerability, which relate to the developmental stage at the time of the insult.
Susan J, Vannucci, Henrik, Hagberg
openaire +2 more sources
Histology of Brain Trauma and Hypoxia-Ischemia [PDF]
Academic Forensic Pathology, 2018 Forensic pathologists encounter hypoxic-ischemic (HI) brain damage or traumatic brain injuries (TBI) on an almost daily basis. Evaluation of the findings guides decisions regarding cause and manner of death. When there are gross findings of brain trauma, the cause of death is often obvious.
Petra, Rahaman, Marc R, Del Bigio
openaire +2 more sources