Results 21 to 30 of about 1,949,320 (295)

Effects of hypoxia‐ischemia on monoamine metabolism in the immature brain [PDF]

Annals of Neurology, 1984
AbstractWe measured acute changes in monoamine metabolites in corpus striatum of immature rat pups exposed to hypoxiaischemia, hypoxia alone, or total global ischemia. Carotid ligations and two hours of 8% oxygen environment in 7‐day‐old pups led to asymmetrical turning behavior, a 70% decrease in endogenous striatal dopamine levels, and a 125 ...
Silverstein, Faye Sarah, Johnston, Michael V.   +1 more
openaire   +3 more sources

Autophagy in hypoxia-ischemia induced brain injury: Evidences and speculations [PDF]

Autophagy, 2009
The interaction among autophagy, apoptosis and necrosis is complex and still a matter of debate. We have recently studied this interaction after neonatal hypoxia-ischemia (HI) in rats. We found that autophagic and apoptotic pathways were significantly increased at short times after HI in neuronal cells. 3-Methyladenine (3-MA) and wortmannin (WM), which
BALDUINI, WALTER, CARLONI, SILVIA, BUONOCORE G.   +2 more
openaire   +5 more sources

A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]

, 2001
Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Darren Caldwell, Caldwell, Darren, Feruza Nuritova, Bruno G. Frenguelli, Dale, Nicholas, Pearson, Tim, Nuritova, Feruza, Frenguelli, Bruno G., Tim Pearson, Nicholas Dale   +9 more
core   +1 more source

Roles of nitric oxide in brain hypoxia-ischemia

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1999
A large body of evidence has appeared over the last 6 years suggesting that nitric oxide biosynthesis is a key factor in the pathophysiological response of the brain to hypoxia-ischemia. Whilst studies on the influence of nitric oxide in this phenomenon initially offered conflicting conclusions, the use of better biochemical tools, such as selective ...
Bolaños, Juan P, Almeida, Angeles
openaire   +2 more sources

The effects of hyperglycaemic hypoxia on rectification in rat dorsal root axons [PDF]

, 1994
1. Electrotonic responses to 150 ms current pulses were recorded from isolated rat dorsal roots incubated for at least 3 h with either normal (5 mM) or high (25 mM) D-glucose solutions, and with either normal (25 mM) or low (5 mM) bicarbonate ...
U Schneider, H Bostock, Schneider, Uwe, Grafe, Peter, Bostock, Hugh, P Grafe   +5 more
core   +2 more sources

A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]

, 2011
The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Mark J. Wall, Atterbury, Alison, Wall, Mark J., Alison Atterbury   +3 more
core   +1 more source

Prednisolone as preservation additive prevents from ischemia reperfusion injury in a rat model of orthotopic lung transplantation [PDF]

, 2013
The lung is, more than other solid organs, susceptible for ischemia reperfusion injury after orthotopic transplantation. Corticosteroids are known to potently suppress pro-inflammatory processes when given in the post-operative setting or during ...
Haitham Mutlak, Paulus, Patrick, Mutlak, Haitham, Johannes Holfeld, Haitham Mutlak (452006), Sabine Tacke (318720), David Stay (452009), Patrick Paulus, Holfeld, Johannes, Urbschat, Anja, Christin Reissig, Pia Alexandra Ockelmann, Reissig, Christin, Zacharowski, Kai, Tacke, Sabine, Bertram Scheller (318724), Stay, David, Bertram Scheller, Ockelmann, Pia Alexandra, Scheller, Bertram, Kai Zacharowski (77285), Sabine Tacke, Johannes Holfeld (318725), Patrick Paulus (318716), Anja Urbschat, Kai Zacharowski, Christin Reissig (452008), Anja Urbschat (318726), David Stay, Pia Alexandra Ockelmann (452007)   +29 more
core   +2 more sources

Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation [PDF]

, 2007
Ischemia is a major cause of brain damage, and patient management is complicated by the paradoxical injury that results from reoxygenation. We have now explored the generation of reactive oxygen species (ROS) in hippocampal and cortical neurons in ...
SCORZIELLO, ANTONELLA, Abramov, A.Y., Duchen, M.R., Abramov AY, Scorziello, A., Duchen MR   +5 more
core   +1 more source

Inhaled 45–50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia

Neurobiology of Disease, 2016
Cooling to 33.5 °C in babies with neonatal encephalopathy significantly reduces death and disability, however additional therapies are needed to maximize brain protection.
Kevin D. Broad, Igor Fierens, Bobbi Fleiss, Eridan Rocha-Ferreira, Mojgan Ezzati, Jane Hassell, Daniel Alonso-Alconada, Alan Bainbridge, Go Kawano, Daqing Ma, Ilias Tachtsidis, Pierre Gressens, Xavier Golay, Robert D. Sanders, Nicola J. Robertson   +14 more
doaj   +1 more source

Analysis of GWAS-Derived Schizophrenia Genes for Links to Ischemia-Hypoxia Response of the Brain

Frontiers in Psychiatry, 2020
Obstetric complications (OCs) can induce major adverse conditions for early brain development and predispose to mental disorders, including schizophrenia (SCZ).
Rainald Schmidt-Kastner, Sinan Guloksuz, Sinan Guloksuz, Thomas Kietzmann, Jim van Os, Jim van Os, Jim van Os, Bart P. F. Rutten   +7 more
doaj   +1 more source