Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial [PDF]
, 2015 Background Moderate cooling after birth asphyxia is associated with substantial reductions in death and disability, but additional therapies might provide further benefit.
Azzopardi, D +17 more
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hUC-MSCs Exert a Neuroprotective Effect via Anti-apoptotic Mechanisms in a Neonatal HIE Rat Model
Cell Transplantation, 2019 In this study, we investigated how human umbilical cord mesenchymal stem cells exerted a neuroprotective effect via antiapoptotic mechanisms in a neonatal hypoxic-ischemic encephalopathy rat model. A total of 78 10-day old (P10) rats were used.
Jianwei Xu +6 more
doaj +1 more source
Zdorovʹe Rebenka, 2020 Background. The current algorithm for therapeutic hypothermia in full-term infants with hypoxic-ischemic encephalopathy requires the initiation of hypothermia within the first six hours of life.
K.Yu. Sokolova
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Neural Regeneration Research, 2020 Perinatal hypoxic-ischemic-encephalopathy significantly contributes to neonatal death and life-long disability such as cerebral palsy. Advances in signal processing and machine learning have provided the research community with an opportunity to develop ...
Hamid Abbasi, Charles P Unsworth
doaj +1 more source
Maternal pomegranate juice intake and brain structure and function in infants with intrauterine growth restriction: A randomized controlled pilot study. [PDF]
, 2019 Polyphenol-rich pomegranate juice has been shown to have benefit as a neuroprotectant in animal models of neonatal hypoxic-ischemia. No published studies have investigated maternal polyphenol administration as a potential neuroprotectant in at-risk ...
Alexopoulos, Dimitrios +7 more
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Using of 6% hydroxyethyl starch 130/0.42 in term neonates during acute period of hie. [PDF]
Pediatric Anesthesia and Critical Care Journal (PACCJ), 2019 Introduction Objective of the study is to determine the efficacy of 6% hydroxyethyl starch (HES) 130/0.42 in a balanced crys- talloid solution in term neonates with severe hypoxic-is- chemic encephalopathy.
D. Surkov
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Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. [PDF]
, 2011 Permanent damage to white matter tracts, comprising axons and myelinating oligodendrocytes, is an important component of brain injuries of the newborn that cause cerebral palsy and cognitive disabilities, as well as multiple sclerosis in adults. However,
Baranzini, Sergio E +11 more
core +3 more sources
Argon protects against hypoxic-ischemic brain injury in neonatal rats through activation of Nuclear factor (erythroid-derived 2)-like 2 [PDF]
, 2016 Perinatal hypoxic ischaemic encephalopathy (HIE) has a high mortality rate with neuropsychological impairment. This study investigated the neuroprotective effects of argon against neonatal hypoxic-ischaemic brain injury.
Ciechanowicz, S +6 more
core +1 more source
BMC Pregnancy and Childbirth, 2017 Background Neonatal encephalopathy (NE) affects 2–4/1000 live births with outcomes ranging from negligible neurological deficits to severe neuromuscular dysfunction, cerebral palsy and death.
Vanessa E. Torbenson +8 more
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Can we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy?
Neural Regeneration Research, 2019 Perinatal hypoxic-ischemic encephalopathy is a leading cause of neonatal death and disability. Therapeutic hypothermia significantly reduces death and major disability associated with hypoxic-ischemic encephalopathy; however, many infants still ...
Anthony Davies +4 more
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