Results 51 to 60 of about 34,963 (242)

Early identification of brain injury in infants with hypoxic ischemic encephalopathy at high risk for severe impairments: accuracy of MRI performed in the first days of life [PDF]

, 2014
BACKGROUND: Despite therapeutic hypothermia 30-70% of newborns with moderate or severe hypoxic ischemic encephalopathy will die or survive with significant long-term impairments.
Alfredo Garcia-Alix, Gemma Arca, Jordi Muchart, Marisol León, Mónica Rebollo, Thais Agut   +5 more
core   +1 more source

Behavioral and epileptic phenotypes in a CHD2‐related developmental delay model

Epilepsia, EarlyView.
Abstract Objective Heterozygous loss‐of‐function mutations in the CHD2 gene, encoding chromodomain helicase DNA‐binding protein 2, are associated with severe childhood onset epilepsy, global developmental delay, and autistic features. Animal models that accurately recapitulate human phenotypes are crucial for understanding rare neurodevelopmental ...
Anat Mavashov, Shaked Turk, Yael Sarusi, Marina Brusel, Rotem Ben Tov Perry, Shir Quinn, Yael Almog, Karni Vilian, Mor Yam, Igor Ulitsky, Moran Rubinstein   +10 more
wiley   +1 more source

New horizons for newborn brain protection: enhancing endogenous neuroprotection. [PDF]

, 2015
Intrapartum-related events are the third leading cause of childhood mortality worldwide and result in one million neurodisabled survivors each year. Infants exposed to a perinatal insult typically present with neonatal encephalopathy (NE).
Alonso-Alconada, D, Ezzati, M, Hassell, KJ, Hausenloy, DJ, Robertson, NJ   +4 more
core   +2 more sources

Evolution of the European Medicines Agency clinical guidelines for epilepsy drug development between 2010 and 2025: A comparative analysis by the ILAE Task Force on Regulatory Affairs

Epilepsia, EarlyView.
Abstract Objective The latest European Medicines Agency (EMA) guideline on the clinical investigation of medicines to treat epileptic disorders was adopted by the EMA Committee for Medicinal Products for Human Use in 2025. We compared this guideline with the previous version (2010), highlighting areas where significant revisions were introduced ...
Stéphane Auvin, Alexis Arzimanoglou, Jacqueline French, Kelly G. Knupp, Lieven Lagae, Eugen Trinka, Dennis Dlugos, Emilio Perucca   +7 more
wiley   +1 more source

The Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxia

Animals, 2022
The purpose of the present study was to determine hypoxic brain damage in calves with perinatal asphyxia using brain-specific damage biomarkers. Ten healthy and 25 calves with perinatal asphyxia were enrolled in the study.
Mahmut Ok, Amir Naseri, Mehmet Burak Ates, Merve Ider, Kamil Uney, Mutlu Sevinc, Fatih Hatipoglu, Ramazan Yildiz, Alper Erturk, Nuri Baspinar, Suleyman Serhat Iyigun   +10 more
doaj   +1 more source

Management and investigation of neonatal encephalopathy: 2017 update. [PDF]

, 2017
This review discusses an approach to determining the cause of neonatal encephalopathy, as well as current evidence on resuscitation and subsequent management of hypoxic-ischaemic encephalopathy (HIE).
Hart, AR, Martinello, K, Mitra, S, Robertson, NJ, Yap, S   +4 more
core   +1 more source

Lactate receptor HCAR1 in neonatal hypoxic–ischemic seizures

Epilepsia, EarlyView.
Abstract Hydroxycarboxylic acid receptor 1 (HCAR1) is a G‐protein‐coupled lactate receptor expressed in the brain and plays a role in neuronal excitability and repair after injury. Hypoxic–ischemic encephalopathy (HIE) is the most common cause of brain injury and seizures in term neonates.
Jennifer Burnsed, Angelina June, Maria Marlicz, Emmy Zucker, Ellie Kain‐Kuzniewski, Hannah Mulhern, Leanne Maharaj, John Williamson, Chengsan Sun, Suchitra Joshi, Huayu Sun, Jaideep Kapur   +11 more
wiley   +1 more source

Time of day/unit busyness at birth and perinatal hypoxia and or moderate to severe hypoxic ischemic encephalopathy a cohort study

The Journal of Maternal-Fetal & Neonatal Medicine
Objectives To investigate the potential link between nighttime births, unit busyness, and the incidence of perinatal hypoxia or moderate-to-severe hypoxic-ischemic encephalopathy.Methods Retrospective cohort study with nested case control study of all ...
Stephen Wood, Selphee Tang, Khorsid Mohammad, Matt Hicks   +3 more
doaj   +1 more source

Early changes in pro-inflammatory cytokine levels in neonates with encephalopathy are associated with remote epilepsy. [PDF]

, 2019
BackgroundNeonatal seizures are associated with adverse neurologic sequelae including epilepsy in childhood. Here we aim to determine whether levels of cytokines in neonates with brain injury are associated with acute symptomatic seizures or remote ...
Barkovich, A James, Deng, Xutao, Ferriero, Donna M, Foster-Barber, Audrey, Glass, Hannah C, Numis, Adam L, Rogers, Elizabeth E   +6 more
core  

Seizure burden and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy. [PDF]

, 2016
Aim: To examine the relationship between electrographic seizures and long-term outcome in neonates with hypoxic-ischemic encephalopathy (HIE). Method: Full-term neonates with HIE born in Cork University Maternity Hospital from 2003 to 2006 (pre ...
Ahearne, Caroline E., Boylan, Geraldine B., Kharoshankaya, Liudmila, Livingstone, Vicki, Murphy, Brendan P., Murray, Deirdre M., Stevenson, Nathan J.   +6 more
core   +1 more source