Results 121 to 130 of about 16,226,491 (322)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Intubation Success through I-Gel® and Intubating Laryngeal Mask Airway® Using Flexible Silicone Tubes: A Randomised Noninferiority Trial

Anesthesiology Research and Practice, 2016
Introduction. The study aims to test whether flexible silicone tubes (FST) improve performance and provide similar intubation success through I-Gel as compared to ILMA. Our trial is registered in CTRI and the registration number is “CTRI/2016/06/006997.”
L. Naik, N. Bhardwaj, I. Sen, R. Sondekoppam   +3 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Projective-injective modules, Serre functors and symmetric algebras [PDF]

, 2005
We describe Serre functors for (generalisations of) the category O associated with a semi-simple complex Lie algebra. In our approach, projective-injective modules play an important role.
Mazorchuk, Volodymyr, Stroppel, Catharina   +1 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

I-GEL(TM) VS. AURAONCE(TM) LARYNGEAL MASK FOR GENERAL ANAESTHESIA WITH CONTROLLED VENTILATION IN PARALYZED PATIENTS [PDF]

, 2011
William Donaldson, Alexander Abraham, M. Deighan, Pavel Michálek   +3 more
openalex   +1 more source

I-gel versus laryngeal mask airway-Proseal: Comparison of two supraglottic airway devices in short surgical procedures

Journal of Anaesthesiology Clinical Pharmacology, 2015
Background and Aims: Supraglottic airway devices have been established in clinical anesthesia practice and have been previously shown to be safe and efficient.
P. A. Jadhav, N. Dalvi, B. Tendolkar
semanticscholar   +1 more source

Elektrokemijska detekcija mikročestica gela u morskoj vodi [PDF]

, 2006
We present the first atomic force microscopy (AFM) images of the native marine gel network and a new type of electrochemical signals of individual gel microparticles in seawater.
Amela Hozić Zimmermann, Eric Balnois, Jean Chevalet, Neda Vdović, Solveg Kovač, Vera Žutić, Vesna Svetličić   +6 more
core   +1 more source

Strong Lefschetz elements of the coinvariant rings of finite Coxeter groups

, 2008
For the coinvariant rings of finite Coxeter groups of types other than H$_4$, we show that a homogeneous element of degree one is a strong Lefschetz element if and only if it is not fixed by any reflections.
A Borel, Akihito Wachi, HL Hiller, IN Bernšteǐn, JE Humphreys, L Smith, ML Mehta, P Griffiths, SL Kleiman, T Harima, Toshiaki Maeno, Y Numata, Yasuhide Numata   +12 more
core   +1 more source