Results 91 to 100 of about 17,799,762 (307)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Mode I stress intensity factor with various crack types
Fracture and Structural Integrity, 2021 Presence of cracks in mechanical components needs much attention, where the stress field is affected by cracks and the propagation of cracks may be occurred causing the damage.
Ehab Samir Mohamed Mohamed Soliman
doaj
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Deixeu els llibres i entrem al museu!
, 2015 Treball Final de Màster Universitari en Professor/a d'Educació Secundària Obligatòria i Batxillerat, Formació Professional i Ensenyaments d'Idiomes. Codi: SAP319.
Calduch i Ferreres, Maria Amparo
core
Journal of Marine Science and EngineeringTo clarify the hydrodynamic interference characteristics of flows around multiple cylinders under the wall effect, the two-dimensional (2D) flows around the near-wall single, two tandem and parallel cylinders are simulated under different gap ratios (0 ...
Xing Chang +4 more
doaj +1 more source
Interactions of double slanted cracks under mode I loading
MATEC Web of Conferences, 2017 This paper presents numerical analysis of double slanted central cracks in square plates under mode I tension stress. ANSYS finite element program is used to model and solve the problem of slanted cracks where the stress intensity factor is determined ...
Ismail Al Emran +6 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Programme du séminaire "Histoire & Mode", Centre d'histoire sociale du XXe siècle - Paris I Sorbonne
, 2017 Séminaire de recherche “MODE & HISTOIRE” Centre d’Histoire sociale / Paris I - IHTP / CNRS Dr. Maude Bass-Krueger et Dr. Sophie Kurkdjian En collaboration avec Pascale Goetschel et Julie Verlaine et Pascal Ory Contact: maudebk@gmail.com et sokurkdjian ...
Sophie Kurkdjian
core
Journal of Theoretical and Applied Electronic Commerce ResearchExemplified by EcoStruxure from Schneider and CASICloud, production-capacity-sharing platforms typically operate as two-sided platforms. These platforms contribute to carbon emission reductions while generating revenue through uniform membership fees ...
Daozhi Zhao +3 more
doaj +1 more source